{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTIA‐1 is a multifunctional RNA‐binding protein that plays a central role in regulating alternative pre–mRNA splicing. By binding to U‐rich intronic sequences located immediately downstream of weak 5′ splice sites, TIA‐1 promotes U1 small nuclear ribonucleoprotein recruitment and accurate exon recognition. This splicing regulatory function has been documented for several important transcripts—including Fas, CFTR, and SMN2—where the coordinated action of its RNA recognition motifs (RRMs) and prion‐like domains is critical for proper exon inclusion and splicing fidelity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to splicing regulation, TIA‐1 functions as a translational silencer. By binding to specific bipartite, U‐rich elements typically located in the 3′ untranslated regions of target mRNAs, TIA‐1 represses translation and facilitates the decay of select transcripts. This post‐transcriptional control mechanism is particularly relevant in the regulation of inflammatory mediators and other stress‐responsive genes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTIA‐1 is also an essential component of cytoplasmic stress granules—dynamic ribonucleoprotein aggregates that form in response to cellular stress. By undergoing liquid–liquid phase separation (a process modulated by zinc and other factors), TIA‐1 sequesters mRNAs and associated proteins into stress granules. Perturbation of this process by disease‐associated mutations leads to delayed granule disassembly and abnormal protein aggregation, phenomena that have been implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Welander distal myopathy, and multisystem proteinopathy. Moreover, cross‐seeding interactions between mutant huntingtin aggregates and TIA‐1 further underscore its role in the pathology of neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in RNA processing and stress responses, TIA‐1 influences cellular growth, survival, and oncogenesis. Through its regulation of alternative splicing and translational control, TIA‐1 modulates the expression of key factors involved in inflammation, angiogenesis, and tumor suppression. Altered expression and isoform‐specific functions of TIA‐1 have been linked to carcinomas of the colon, esophagus, and liver. In parallel, TIA‐1 has been shown to affect mitochondrial dynamics by promoting fission via enhanced translation of mitochondrial fission factor. These multifaceted roles underscore TIA‐1’s contribution to cell proliferation, invasion, and the metabolic adaptations observed in cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTIA‐1 also participates in host–virus interactions and in fine‐tuning its own functional diversity. In settings of viral infection, such as during herpes simplex virus, poliovirus, and enterovirus D68 challenges, TIA‐1 redistributes to stress granules where it can bind viral RNAs and potentially impair viral replication. Complementary structural and isoform‐specific studies have revealed that distinct TIA‐1 domains dictate ligand specificity and subcellular localization, while interactions with other RNA–binding proteins further modulate its activities in stress granule assembly and splicing regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "33", "end_ref": "39"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karli K McDonald, Anaïs Aulas, Laurie Destroismaisons, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddr021"}], "href": "https://doi.org/10.1093/hmg/ddr021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21257637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21257637"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "P Förch, O Puig, N Kedersha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2000)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(00)00107-6"}], "href": "https://doi.org/10.1016/s1097-2765(00"}, {"type": "t", "text": "00107-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11106748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11106748"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Patrik Förch, Oscar Puig, Concepción Martínez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdf668"}], "href": "https://doi.org/10.1093/emboj/cdf668"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12486009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12486009"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Isabel Aznarez, Yoseph Barash, Ofer Shai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.073155.107"}], "href": "https://doi.org/10.1101/gr.073155.107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18456862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18456862"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Elisabetta Zuccato, Emanuele Buratti, Cristiana Stuani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M313439200"}], "href": "https://doi.org/10.1074/jbc.M313439200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14966131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14966131"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Natalia N Singh, Joonbae Seo, Eric W Ottesen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00945-10"}], "href": "https://doi.org/10.1128/MCB.00945-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21189287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21189287"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "José M Izquierdo, Juan Valcárcel "}, {"type": "b", "children": [{"type": "t", "text": "Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C600198200"}], "href": "https://doi.org/10.1074/jbc.C600198200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17135269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17135269"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Inti Zlobec, Eva Karamitopoulou, Luigi Terracciano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0014282"}], "href": "https://doi.org/10.1371/journal.pone.0014282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21179245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21179245"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "José M Izquierdo, José Alcalde, Isabel Carrascoso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumour growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20101030"}], "href": "https://doi.org/10.1042/BJ20101030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21284605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21284605"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Isabel López de Silanes, Stefanie Galbán, Jennifer L Martindale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.21.9520-9531.2005"}], "href": "https://doi.org/10.1128/MCB.25.21.9520-9531.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16227602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16227602"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Audrey Esclatine, Brunella Taddeo, Bernard Roizman "}, {"type": "b", "children": [{"type": "t", "text": "Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.78.16.8582-8592.2004"}], "href": "https://doi.org/10.1128/JVI.78.16.8582-8592.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15280467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15280467"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Satoshi Yamasaki, Georg Stoecklin, Nancy Kedersha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T-cell intracellular antigen-1 (TIA-1)-induced translational silencing promotes the decay of selected mRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M706273200"}], "href": "https://doi.org/10.1074/jbc.M706273200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17711853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17711853"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ian R Mackenzie, Alexandra M Nicholson, Mohona Sarkar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2017.07.025"}], "href": "https://doi.org/10.1016/j.neuron.2017.07.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28817800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28817800"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Peter Hackman, Jaakko Sarparanta, Sara Lehtinen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.23831"}], "href": "https://doi.org/10.1002/ana.23831"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23401021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23401021"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kyoko Arimoto-Matsuzaki, Haruo Saito, Mutsuhiro Takekawa "}, {"type": "b", "children": [{"type": "t", "text": "TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10252"}], "href": "https://doi.org/10.1038/ncomms10252"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26738979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26738979"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Joakim Klar, Maria Sobol, Atle Melberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Welander distal myopathy caused by an ancient founder mutation in TIA1 associated with perturbed splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22282"}], "href": "https://doi.org/10.1002/humu.22282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23348830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23348830"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yoshiaki Furukawa, Kumi Kaneko, Gen Matsumoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0783-09.2009"}], "href": "https://doi.org/10.1523/JNEUROSCI.0783-09.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19386911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19386911"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "YouJin Lee, Per Harald Jonson, Jaakko Sarparanta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI97103"}], "href": "https://doi.org/10.1172/JCI97103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29457785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29457785"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Joseph B Rayman, Kevin A Karl, Eric R Kandel "}, {"type": "b", "children": [{"type": "t", "text": "TIA-1 Self-Multimerization, Phase Separation, and Recruitment into Stress Granules Are Dynamically Regulated by Zn"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2017.12.036"}], "href": "https://doi.org/10.1016/j.celrep.2017.12.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29298433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29298433"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kengo Fujita, Hidefumi Ito, Satoshi Nakano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-008-0415-x"}], "href": "https://doi.org/10.1007/s00401-008-0415-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18642007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18642007"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Naotaka Sekiyama, Kiyofumi Takaba, Saori Maki-Yonekura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2122523119"}], "href": "https://doi.org/10.1073/pnas.2122523119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36112647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36112647"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Zhenhua Yuan, Bin Jiao, Lihua Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation analysis of the TIA1 gene in Chinese patients with amyotrophic lateral sclerosis and frontotemporal dementia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2017.12.017"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2017.12.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29370934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29370934"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Dan A Dixon, Glen C Balch, Nancy Kedersha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20030616"}], "href": "https://doi.org/10.1084/jem.20030616"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12885872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12885872"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yanqing Liu, Rui Liu, Fei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-017-0625-8"}], "href": "https://doi.org/10.1186/s12943-017-0625-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28257633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28257633"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "T S Karin Eisinger-Mathason, Josefa Andrade, Angela L Groehler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.06.025"}], "href": "https://doi.org/10.1016/j.molcel.2008.06.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18775331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18775331"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Maryam A Hamdollah Zadeh, Elianna M Amin, Coralie Hoareau-Aveilla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molonc.2014.07.017"}], "href": "https://doi.org/10.1016/j.molonc.2014.07.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25224594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25224594"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Xianjue Ma, Hongxiang Wang, Jiansong Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hippo signaling promotes JNK-dependent cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1621359114"}], "href": "https://doi.org/10.1073/pnas.1621359114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28174264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28174264"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Xuefeng Yang, Mingda Wang, Bohao Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-487a promotes progression of gastric cancer by targeting TIA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochimie (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biochi.2018.08.006"}], "href": "https://doi.org/10.1016/j.biochi.2018.08.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30144499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30144499"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Hyosun Tak, Jung Woo Eun, Jihye Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T-cell-restricted intracellular antigen 1 facilitates mitochondrial fragmentation by enhancing the expression of mitochondrial fission factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2016.90"}], "href": "https://doi.org/10.1038/cdd.2016.90"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27612012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27612012"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Junichi Hamada, Katsutoshi Shoda, Kiyoshi Masuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7937"}], "href": "https://doi.org/10.18632/oncotarget.7937"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26958940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26958940"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Hyosun Tak, Hoin Kang, Eunbyul Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential use of TIA-1, MFF, microRNA-200a-3p, and microRNA-27 as a novel marker for hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.02.189"}], "href": "https://doi.org/10.1016/j.bbrc.2018.02.189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29496454"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29496454"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Alice Pasini, Oliver J Brand, Gisli Jenkins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Gene Regul Mech (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2018.03.007"}], "href": "https://doi.org/10.1016/j.bbagrm.2018.03.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29555582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29555582"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Katy Milne, Martin Köbel, Steven E Kalloger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0006412"}], "href": "https://doi.org/10.1371/journal.pone.0006412"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19641607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19641607"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Zhen Wang, Melis Kayikci, Michael Briese, et al. "}, {"type": "b", "children": [{"type": "t", "text": "iCLIP predicts the dual splicing effects of TIA-RNA interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.1000530"}], "href": "https://doi.org/10.1371/journal.pbio.1000530"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21048981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21048981"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Iren Wang, Janosch Hennig, Pravin Kumar Ankush Jagtap, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gku193"}], "href": "https://doi.org/10.1093/nar/gku193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24682828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24682828"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "José M Izquierdo, Juan Valcárcel "}, {"type": "b", "children": [{"type": "t", "text": "Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M700688200"}], "href": "https://doi.org/10.1074/jbc.M700688200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17488725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17488725"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Jinyan Cheng, Shuai Gao, Cheng Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02041-19"}], "href": "https://doi.org/10.1128/JVI.02041-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31941779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31941779"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Saboora Waris, Sofía M García-Mauriño, Andrew Sivakumaran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIA-1 RRM23 binding and recognition of target oligonucleotides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx102"}], "href": "https://doi.org/10.1093/nar/gkx102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28184449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28184449"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Kerry D Fitzgerald, Bert L Semler "}, {"type": "b", "children": [{"type": "t", "text": "Poliovirus infection induces the co-localization of cellular protein SRp20 with TIA-1, a cytoplasmic stress granule protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virus Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virusres.2013.06.012"}], "href": "https://doi.org/10.1016/j.virusres.2013.06.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23830997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23830997"}]}]}]}