TICAM1 Gene

Name	toll-like receptor adaptor molecule 1
Description	This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTICAM1 (also known as TRIF) is a Toll/IL‑1 receptor (TIR) domain‐containing adaptor protein that mediates MyD88‑independent signaling primarily downstream of Toll‑like receptor (TLR) 3 and, in association with bridging molecules, TLR4. It is rapidly recruited upon receptor engagement, where it undergoes phosphorylation and oligomerization to form dynamic signaling “speckles.” In these complexes, TICAM1 binds key downstream effectors such as TRAF6 and TBK1 that, in turn, drive the phosphorylation and activation of interferon regulatory factor 3 (IRF3) and NF‑κB. This molecular cascade leads to the induction of type I interferon and other antiviral cytokines, establishing a critical innate immune response to viral infection."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies reveal that TICAM1’s function is intricately regulated and, at times, subverted by pathogens. Through specific binding motifs and interactions with accessory adaptor proteins (for example, TICAM‑2 in TLR4 signaling), TICAM1 not only coordinates cytokine induction but also contributes to apoptotic responses when appropriate. Moreover, various viruses—including enteroviruses and herpes simplex virus—target TICAM1 for proteolytic cleavage to impair interferon production and facilitate immune evasion. Human genetic defects in TICAM1 are associated with increased susceptibility to severe viral infections, underscoring its indispensable role in antiviral defense. Recent evidence further indicates participation of TICAM1 in non‑canonical TLR signaling (for example, in TLR5‑mediated pathways), collectively highlighting TICAM1’s versatility in orchestrating balanced immune responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Masahiro Yamamoto, Shintaro Sato, Kiyotoshi Mori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.169.12.6668"}], "href": "https://doi.org/10.4049/jimmunol.169.12.6668"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12471095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12471095"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hiroyuki Oshiumi, Misako Matsumoto, Kenji Funami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni886"}], "href": "https://doi.org/10.1038/ni886"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12539043"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12539043"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hiroyuki Oshiumi, Miwa Sasai, Kyoko Shida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M305820200"}], "href": "https://doi.org/10.1074/jbc.M305820200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14519765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14519765"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shintaro Sato, Masanaka Sugiyama, Masahiro Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.171.8.4304"}], "href": "https://doi.org/10.4049/jimmunol.171.8.4304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14530355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14530355"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ke-Jun Han, Xiaoqin Su, Liang-Guo Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M311629200"}], "href": "https://doi.org/10.1074/jbc.M311629200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14739303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14739303"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhengfan Jiang, Tak W Mak, Ganes Sen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0308496101"}], "href": "https://doi.org/10.1073/pnas.0308496101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14982987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14982987"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "William J Kaiser, Margaret K Offermann "}, {"type": "b", "children": [{"type": "t", "text": "Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.174.8.4942"}], "href": "https://doi.org/10.4049/jimmunol.174.8.4942"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15814722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15814722"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Michael Carty, Rory Goodbody, Martina Schröder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni1382"}], "href": "https://doi.org/10.1038/ni1382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16964262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16964262"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kenji Funami, Miwa Sasai, Yusuke Ohba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.179.10.6867"}], "href": "https://doi.org/10.4049/jimmunol.179.10.6867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17982077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17982077"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kenji Funami, Miwa Sasai, Hiroyuki Oshiumi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M801013200"}], "href": "https://doi.org/10.1074/jbc.M801013200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18450748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18450748"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hongmei Xu, Huazhang An, Jin Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2008.05.006"}], "href": "https://doi.org/10.1016/j.molimm.2008.05.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18571728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18571728"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Christopher S McAllister, Charles E Samuel "}, {"type": "b", "children": [{"type": "t", "text": "The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M807888200"}], "href": "https://doi.org/10.1074/jbc.M807888200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19028691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19028691"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yoon Jeong Choi, Eunok Im, Hyo Kyun Chung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.158394"}], "href": "https://doi.org/10.1074/jbc.M110.158394"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20855887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20855887"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Humera Ahmad, Rachel Gubbels, Erica Ehlers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kaposi sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domain-containing adaptor-inducing beta-interferon (TRIF)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.191452"}], "href": "https://doi.org/10.1074/jbc.M110.191452"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21212282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21212282"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiaobo Lei, Zhenmin Sun, Xinlei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00447-11"}], "href": "https://doi.org/10.1128/JVI.00447-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21697485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21697485"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hiroyuki Oshiumi, Masaaki Okamoto, Ken Fujii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1101503"}], "href": "https://doi.org/10.4049/jimmunol.1101503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21998457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21998457"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Vanessa Sancho-Shimizu, Rebeca Pérez de Diego, Lazaro Lorenzo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI59259"}], "href": "https://doi.org/10.1172/JCI59259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22105173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22105173"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Zichun Xiang, Linlin Li, Xiaobo Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enterovirus 68 3C protease cleaves TRIF to attenuate antiviral responses mediated by Toll-like receptor 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.03138-13"}], "href": "https://doi.org/10.1128/JVI.03138-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24672048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24672048"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Siqi Liu, Xin Cai, Jiaxi Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aaa2630"}], "href": "https://doi.org/10.1126/science.aaa2630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25636800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25636800"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yun-Hong Hu, Yu Zhang, Li-Qun Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WDFY1 mediates TLR3/4 signaling by recruiting TRIF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201439637"}], "href": "https://doi.org/10.15252/embr.201439637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25736436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25736436"}]}]}]}
Synonyms	MYD88-3, TICAM-1, PRVTIRB, IIAE6
Proteins	TCAM1_HUMAN
NCBI Gene ID	148022
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TICAM1 has 7,613 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 123 datasets.

Click the + buttons to view associations for TICAM1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TICAM1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TICAM1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TICAM1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TICAM1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TICAM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TICAM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TICAM1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TICAM1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TICAM1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TICAM1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TICAM1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TICAM1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TICAM1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TICAM1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TICAM1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TICAM1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TICAM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TICAM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TICAM1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TICAM1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TICAM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TICAM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TICAM1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TICAM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TICAM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TICAM1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TICAM1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TICAM1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TICAM1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TICAM1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TICAM1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TICAM1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TICAM1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TICAM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TICAM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TICAM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TICAM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TICAM1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TICAM1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TICAM1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TICAM1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.