TIMM17A Gene

Name	translocase of inner mitochondrial membrane 17 homolog A (yeast)
Description	Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial inner membrane and nucleoplasm. Part of TIM23 mitochondrial import inner membrane translocase complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTIMM17A is a critical component of the mitochondrial inner membrane translocase complex, playing an essential role in the import of nuclear‐encoded proteins into mitochondria. Its conserved structural features, such as negatively charged residues and the ability to interact with amphiphilic presequence signals, ensure proper sorting of proteins either into the inner membrane or the matrix, thereby maintaining mitochondrial function across eukaryotes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn breast cancer, aberrant overexpression of TIMM17A has been convincingly demonstrated in several studies. Quantitative proteomic approaches have identified TIMM17A as one of the novel markers that are upregulated in the transition from normal to primary and metastatic breast tumors, with its mRNA expression levels directly correlating with tumor progression and clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In parallel, investigations into noncoding RNA regulation have revealed that silencing of miR-133b—mediated in part by upregulated lncRNA NEAT1—leads to a de-repression of TIMM17A, further enhancing breast cancer cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther supporting its clinical relevance, analyses of benign versus malignant breast tissues have confirmed deregulated TIMM17A mRNA expression, underscoring its value as a biomarker in oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Beyond its role in cancer cell behavior, TIMM17A has also been implicated in the maintenance of mitochondrial DNA stability. Overexpression studies in yeast and human cellular models have shown that TIMM17A can suppress mtDNA instability and prevent the loss of mitochondrial genomes, highlighting its broader importance in mitochondrial homeostasis and suggesting potential implications in mitochondrial diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, the prognostic and therapeutic potential of TIMM17A is not confined to breast cancer. Recent studies in lung adenocarcinoma have demonstrated that TIMM17A is significantly upregulated in tumor tissues, with its expression levels correlating with advanced clinical stage, lymph node metastasis, and reduced overall and progression-free survival. These findings support the role of TIMM17A as an independent prognostic biomarker and potential therapeutic target in lung adenocarcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Laura F Fielden, Jakob D Busch, Sandra G Merkt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Central role of Tim17 in mitochondrial presequence protein translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-023-06477-8"}], "href": "https://doi.org/10.1038/s41586-023-06477-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37527780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37527780"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Minu Chaudhuri, Chauncey Darden, Fidel Soto Gonzalez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial Protein Translocator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom10121643"}], "href": "https://doi.org/10.3390/biom10121643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33297490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33297490"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoen Xu, Meng Qiao, Yang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitative proteomics study of breast cancer cell lines isolated from a single patient: discovery of TIMM17A as a marker for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pmic.200900380"}], "href": "https://doi.org/10.1002/pmic.200900380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20198662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20198662"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaomei Yang, Yang Si, Tao Tao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Impact of TIMM17A on Aggressiveness of Human Breast Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26977020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26977020"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xinping Li, Siwei Deng, Xinyao Pang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NEAT1 Silenced miR-133b Promotes Migration and Invasion of Breast Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20153616"}], "href": "https://doi.org/10.3390/ijms20153616"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31344855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31344855"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mohamed Salhab, Neill Patani, Wen Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High TIMM17A expression is associated with adverse pathological and clinical outcomes in human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12282-010-0228-3"}], "href": "https://doi.org/10.1007/s12282-010-0228-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20972741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20972741"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Michelina Iacovino, Caroline Granycome, Hiroshi Sembongi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The conserved translocase Tim17 prevents mitochondrial DNA loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddn313"}], "href": "https://doi.org/10.1093/hmg/ddn313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18826960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18826960"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Lili Miao, Dejun Wu, Hongyu Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIMM17A overexpression in lung adenocarcinoma and its association with prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-59526-1"}], "href": "https://doi.org/10.1038/s41598-024-59526-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38632467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38632467"}]}]}]}
Synonyms	TIM17, TIM17A
Proteins	TI17A_HUMAN
NCBI Gene ID	10440
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TIMM17A has 6,380 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 112 datasets.

Click the + buttons to view associations for TIMM17A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TIMM17A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TIMM17A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TIMM17A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TIMM17A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TIMM17A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TIMM17A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TIMM17A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TIMM17A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TIMM17A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TIMM17A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TIMM17A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TIMM17A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TIMM17A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TIMM17A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TIMM17A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TIMM17A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TIMM17A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TIMM17A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TIMM17A protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TIMM17A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TIMM17A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TIMM17A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TIMM17A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TIMM17A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TIMM17A protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TIMM17A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TIMM17A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TIMM17A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TIMM17A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TIMM17A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TIMM17A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TIMM17A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TIMM17A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TIMM17A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TIMM17A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TIMM17A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TIMM17A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TIMM17A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TIMM17A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TIMM17A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with TIMM17A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.