{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTJP1, the gene encoding zonula occludens‐1 (ZO‑1), is a central scaffold in intercellular junctions that coordinates the assembly and maintenance of tight junctions and adherens junctions. It mediates the linkage between transmembrane adhesion proteins—including claudins, occludin, cadherins, and connexins—and the actin cytoskeleton, thereby orchestrating paracellular barrier function, cell–cell adhesion, migration, and mechanotransduction during developmental processes and in healthy epithelia and endothelia. In various models—from epithelial cell shedding and gut barrier regulation to neural and somitogenesis studies—TJP1 ensures proper junctional organization and dynamic remodeling in response to intrinsic developmental cues and extrinsic stress signals."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nZO‑1 function is finely regulated by a series of post‐translational modifications, protein–protein interactions, and conformational dynamics that modulate its binding to key partners and its distribution within cells. Phosphorylation events (for example, at sites within occludin’s conserved motifs), regulated interactions with PDZ‐domain–containing proteins, and responses to bioactive lipids such as sphingosine‑1‑phosphate all affect ZO‑1’s dynamic behavior at cell–cell contacts and in intracellular pools. Such modifications not only fine‑tune tight junction permeability and gap junction assembly but also integrate signals from developmental pathways (including Notch and Delta‑like ligand cascades) and stress stimuli, thereby influencing processes such as cytokine‐mediated barrier disruption and transcriptional regulation via binding partners like TAZ."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDysregulation of TJP1 expression or its molecular interactions contributes to the pathogenesis of a wide range of disorders. Aberrant ZO‑1 localization and expression have been implicated in compromised blood–brain barriers (for example, in HIV infection and leukemic cell infiltration), increased intestinal permeability in inflammatory or chemotherapeutic settings, defective lumen formation, and enhanced tumor metastasis through altered intercellular adhesion. Moreover, recent studies highlight its emerging role as a potential biomarker and therapeutic target in conditions ranging from cystic fibrosis and diabetic retinopathy to proteasome inhibitor sensitivity in multiple myeloma. These findings underscore the multifaceted functions of TJP1 as not only a structural component of tight junctions but also as an active regulator of cellular signaling, tissue homeostasis, and disease progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "27", "end_ref": "39"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sally L Dunwoodie, Melanie Clements, Duncan B Sparrow, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Characterization of epithelial cell shedding from human small intestine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.3700464"}], "href": "https://doi.org/10.1038/labinvest.3700464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16909128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16909128"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Larissa Eiselein, Dennis W Wilson, Michael W Lamé, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lipolysis products from triglyceride-rich lipoproteins increase endothelial permeability, perturb zonula occludens-1 and F-actin, and induce apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.00686.2006"}], "href": "https://doi.org/10.1152/ajpheart.00686.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17259442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17259442"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Insa Geffers, Katrin Serth, Gavin Chapman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200702009"}], "href": "https://doi.org/10.1083/jcb.200702009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17664336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17664336"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Alexandra F Bruce, Stephen Rothery, Emmanuel Dupont, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvm083"}], "href": "https://doi.org/10.1093/cvr/cvm083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18056766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18056766"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yueming Tang, Ali Banan, Christopher B Forsyth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Alcohol Clin Exp Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1530-0277.2007.00584.x"}], "href": "https://doi.org/10.1111/j.1530-0277.2007.00584.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18162065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18162065"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "W I de Boer, H S Sharma, S M I Baelemans, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.22465"}], "href": "https://doi.org/10.1002/hep.22465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18802961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18802961"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Bertha C Elias, Takuya Suzuki, Ankur Seth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804783200"}], "href": "https://doi.org/10.1074/jbc.M804783200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19017651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19017651"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "R Michael Henke, David M Meredith, Mark D Borromeo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2009.01.007"}], "href": "https://doi.org/10.1016/j.ydbio.2009.01.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19389376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19389376"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Nina Kirschner, Claudia Poetzl, Peter von den Driesch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2009.080973"}], "href": "https://doi.org/10.2353/ajpath.2009.080973"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19661441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19661441"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Xudong Zhao, Domenico D' Arca, Wei Keat Lim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2009.07.009"}], "href": "https://doi.org/10.1016/j.devcel.2009.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19686682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19686682"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Gavin Chapman, Duncan B Sparrow, Elisabeth Kremmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddq529"}], "href": "https://doi.org/10.1093/hmg/ddq529"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21147753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21147753"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "J Matthew Rhett, Jane Jourdan, Robert G Gourdie "}, {"type": "b", "children": [{"type": "t", "text": "Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E10-06-0548"}], "href": "https://doi.org/10.1091/mbc.E10-06-0548"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21411628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21411628"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yao Yao, Stella E Tsirka "}, {"type": "b", "children": [{"type": "t", "text": "Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.082834"}], "href": "https://doi.org/10.1242/jcs.082834"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21486949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21486949"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "David R Raleigh, Devin M Boe, Dan Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201010065"}], "href": "https://doi.org/10.1083/jcb.201010065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21536752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21536752"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Saran Feng, Jiannong Cen, Yihong Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0020599"}], "href": "https://doi.org/10.1371/journal.pone.0020599"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21857898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21857898"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yu Zhong, Bei Zhang, Sung Yong Eum, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIV-1 Tat triggers nuclear localization of ZO-1 via Rho signaling and cAMP response element-binding protein activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4266-11.2012"}], "href": "https://doi.org/10.1523/JNEUROSCI.4266-11.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22219277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22219277"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Kentaro Nagaoka, Tsuyoshi Udagawa, Joel D Richter "}, {"type": "b", "children": [{"type": "t", "text": "CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1678"}], "href": "https://doi.org/10.1038/ncomms1678"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22334078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22334078"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Ting Wang, Lichun Wang, Liliana Moreno-Vinasco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Part Fibre Toxicol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1743-8977-9-35"}], "href": "https://doi.org/10.1186/1743-8977-9-35"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22931549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22931549"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Stéphanie Beutheu, Ibtissem Ghouzali, Ludovic Galas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Nutr (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clnu.2013.01.014"}], "href": "https://doi.org/10.1016/j.clnu.2013.01.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23428392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23428392"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Christina M Van Itallie, Angel Aponte, Amber Jean Tietgens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.466193"}], "href": "https://doi.org/10.1074/jbc.M113.466193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23553632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23553632"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Ye Chun Ruan, Yan Wang, Nicolas Da Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.148098"}], "href": "https://doi.org/10.1242/jcs.148098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25107366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25107366"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Olga Tornavaca, Minghao Chia, Neil Dufton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201404140"}], "href": "https://doi.org/10.1083/jcb.201404140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25753039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25753039"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Xing-Ding Zhang, Veerabhadran Baladandayuthapani, Heather Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tight Junction Protein 1 Modulates Proteasome Capacity and Proteasome Inhibitor Sensitivity in Multiple Myeloma via EGFR/JAK1/STAT3 Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2016.03.026"}], "href": "https://doi.org/10.1016/j.ccell.2016.03.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27132469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27132469"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Jang-Hyuk Yun, Sung Wook Park, Kyung-Jin Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.25575"}], "href": "https://doi.org/10.1002/jcp.25575"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27580405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27580405"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Matthew A Odenwald, Wangsun Choi, Aaron Buckley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.188185"}], "href": "https://doi.org/10.1242/jcs.188185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27802160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27802160"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Domenica Spadaro, Shimin Le, Thierry Laroche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tension-Dependent Stretching Activates ZO-1 to Control the Junctional Localization of Its Interactors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2017.11.014"}], "href": "https://doi.org/10.1016/j.cub.2017.11.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29199076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29199076"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Oliver Beutel, Riccardo Maraspini, Karina Pombo-García, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2019.10.011"}], "href": "https://doi.org/10.1016/j.cell.2019.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31675499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31675499"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Yuki Yokota, Takehiro Noda, Yuichiro Okumura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum exosomal miR-638 is a prognostic marker of HCC via downregulation of VE-cadherin and ZO-1 of endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.14807"}], "href": "https://doi.org/10.1111/cas.14807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33426736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33426736"}]}]}]}