TKT Gene

Name	transketolase
Description	This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTransketolase (TKT) is a thiamine diphosphate– and Ca²⁺–dependent enzyme of the nonoxidative pentose phosphate pathway that catalyzes reversible two‐carbon transfers between sugar phosphates. Structural and computational studies have revealed that human TKT adopts a conserved three‐domain architecture with unique active–site features governing cofactor binding and catalysis, thereby ensuring efficient production of ribose 5–phosphate and NADPH for biosynthetic and antioxidant needs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn tumor cells, however, TKT assumes additional noncanonical roles that support malignant progression. Elevated TKT expression in cancers such as ovarian, colorectal, and hepatocellular carcinomas enhances NADPH production, thereby counteracting oxidative stress and promoting survival. Moreover, nuclear translocation of TKT and its interactions with regulatory partners—including STAT1, PARP1, and GRP78—facilitate DNA repair mechanisms, foster proliferative signaling, and contribute to resistance against targeted therapies and radiotherapy. Epigenetic analyses have further implicated TKT as a candidate driver linked to clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nInherited and acquired deficiencies in TKT activity can disturb nucleotide metabolism and redox balance, with consequent effects on cell division and growth. Patients with autosomal recessive TKT deficiency present with short stature, developmental delays, congenital heart defects, and abnormal sugar phosphate profiles, while clinical measurement of erythrocyte TKT activity serves as a surrogate marker for thiamine status in disorders of the nervous system."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDistinct differences between human and pathogen TKT enzymes have been exploited for therapeutic purposes. In Mycobacterium tuberculosis, structural variations in TKT compared with the human enzyme highlight its validity as a promising antitubercular drug target. In addition, thiamine–dependent transketolase activity has been shown to mediate a critical two–carbon extension in the biosynthesis of complex natural products such as the azinomycins, underscoring TKT’s broader biochemical versatility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nModulation of TKT activity also has implications for immune and metabolic regulation. Variability in TKT and allied pentose phosphate pathway enzymes is associated with diabetic complications, while altered TKT function influences NADPH production critical for reactive oxygen species formation and neutrophil extracellular trap (NET) release. Moreover, TKT-related disturbances have been linked to vitamin B₁ deficiency states, as observed in conditions such as Crohn’s disease and melanoma, thereby integrating TKT into broader metabolic and inflammatory networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of autoimmunity, specific isoforms of TKT have been identified as autoantigens in multiple sclerosis, with cerebrospinal fluid and serum IgG from patients selectively targeting transketolase, thereby implicating the enzyme in the neuroimmune pathogenesis of the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lars Mitschke, Christoph Parthier, Kathrin Schröder-Tittmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The crystal structure of human transketolase and new insights into its mode of action."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.149955"}], "href": "https://doi.org/10.1074/jbc.M110.149955"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20667822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20667822"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lionel Nauton, Laurence Hecquet, Vincent Théry "}, {"type": "b", "children": [{"type": "t", "text": "QM/MM Study of Human Transketolase: Thiamine Diphosphate Activation Mechanism and Complete Catalytic Cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Chem Inf Model (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jcim.1c00190"}], "href": "https://doi.org/10.1021/acs.jcim.1c00190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34161071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34161071"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Arindam Saha, Stephen Connelly, Jingjing Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2014.05.028"}], "href": "https://doi.org/10.1016/j.molcel.2014.05.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24981175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24981175"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Carmela Ricciardelli, Noor A Lokman, Sowmya Cheruvu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Metastasis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10585-015-9718-1"}], "href": "https://doi.org/10.1007/s10585-015-9718-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25895698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25895698"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Iris Ming-Jing Xu, Robin Kit-Ho Lai, Shu-Hai Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transketolase counteracts oxidative stress to drive cancer development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1508779113"}], "href": "https://doi.org/10.1073/pnas.1508779113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26811478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26811478"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yongchang Zheng, Qianqian Huang, Zijian Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide DNA methylation analysis identifies candidate epigenetic markers and drivers of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brief Bioinform (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/bib/bbw094"}], "href": "https://doi.org/10.1093/bib/bbw094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27760737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27760737"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yongfa Zheng, Pingpo Ming, Chengliang Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis B virus X protein-induced SH2 domain-containing 5 (SH2D5) expression promotes hepatoma cell growth via an SH2D5-transketolase interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.005739"}], "href": "https://doi.org/10.1074/jbc.RA118.005739"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30659097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30659097"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Minle Li, Xuping Zhang, Ying Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2225-6"}], "href": "https://doi.org/10.1038/s41419-020-2225-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31949131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31949131"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Longpo Geng, Mingming Zhu, Dongjun Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-023-02935-9"}], "href": "https://doi.org/10.1038/s41388-023-02935-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38216672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38216672"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sławomir Michalak, Grażyna Michałowska-Wender, Grażyna Adamcewicz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Erythrocyte transketolase activity in patients with diabetic and alcoholic neuropathies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Folia Neuropathol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5114/fn.2013.37706"}], "href": "https://doi.org/10.5114/fn.2013.37706"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24114639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24114639"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dan Ziegler, Erwin Schleicher, Alexander Strom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of transketolase polymorphisms with measures of polyneuropathy in patients with recently diagnosed diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes Metab Res Rev (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dmrr.2811"}], "href": "https://doi.org/10.1002/dmrr.2811"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27103086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27103086"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lia Boyle, Mirjam M C Wamelink, Gajja S Salomons, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in TKT Are the Cause of a Syndrome Including Short Stature, Developmental Delay, and Congenital Heart Defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2016.03.030"}], "href": "https://doi.org/10.1016/j.ajhg.2016.03.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27259054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27259054"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Brian J Shayota, Taraka R Donti, Jing Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Untargeted metabolomics as an unbiased approach to the diagnosis of inborn errors of metabolism of the non-oxidative branch of the pentose phosphate pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2020.07.013"}], "href": "https://doi.org/10.1016/j.ymgme.2020.07.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32828637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32828637"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Elizabeth Fullam, Florence Pojer, Terese Bergfors, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Open Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1098/rsob.110026"}], "href": "https://doi.org/10.1098/rsob.110026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22645655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22645655"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lauren A Washburn, Brendan Foley, Flor Martinez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transketolase Activity in the Formation of the Azinomycin Azabicycle Moiety."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.9b00477"}], "href": "https://doi.org/10.1021/acs.biochem.9b00477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31424204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31424204"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Lukás Pácal, Josef Tomandl, Jan Svojanovsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nephrol Dial Transplant (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ndt/gfq550"}], "href": "https://doi.org/10.1093/ndt/gfq550"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20826743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20826743"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Veronika Tanhäuserová, Katarína Kuricová, Lukáš Pácal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chem Lab Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/cclm-2012-0833"}], "href": "https://doi.org/10.1515/cclm-2012-0833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23492569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23492569"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Donporn Riyapa, Darawan Rinchai, Veerachat Muangsombut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transketolase and vitamin B1 influence on ROS-dependent neutrophil extracellular traps (NETs) formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0221016"}], "href": "https://doi.org/10.1371/journal.pone.0221016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31415630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31415630"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "D Mańkowska-Wierzbicka, S Michalak, J Karczewski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Erythrocyte transketolase deficiency in patients suffering from Crohn's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201910_19163"}], "href": "https://doi.org/10.26355/eurrev_201910_19163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31646581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31646581"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ning Gu, Wei Dai, Hongliang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejca.2020.04.049"}], "href": "https://doi.org/10.1016/j.ejca.2020.04.049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32659474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32659474"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Stefan Schneider, Stefan Lüdtke, Kathrin Schröder-Tittmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A δ38 deletion variant of human transketolase as a model of transketolase-like protein 1 exhibits no enzymatic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0048321"}], "href": "https://doi.org/10.1371/journal.pone.0048321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23118983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23118983"}]}]}]}
Synonyms	TK, HEL107, TKT1, SDDHD, HEL-S-48
Proteins	TKT_HUMAN
NCBI Gene ID	7086
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TKT has 11,018 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for TKT from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TKT Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TKT gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TKT gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TKT gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TKT gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TKT gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TKT gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TKT gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TKT gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TKT gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TKT gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TKT gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TKT gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TKT gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TKT gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TKT protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TKT protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TKT protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TKT protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TKT protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TKT protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TKT gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TKT gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TKT gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TKT gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TKT protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TKT gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TKT gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TKT gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TKT gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TKT gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TKT gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TKT gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TKT gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TKT gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TKT from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with TKT gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with TKT gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of TKT gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with TKT gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing TKT from the GeneSigDB Published Gene Signatures dataset.