{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTransducin‐like enhancer of split 1 (TLE1) is a multifunctional transcriptional corepressor that plays a pivotal role in modulating diverse developmental and signaling pathways. Rather than binding DNA directly, TLE1 regulates gene expression by forming oligomeric complexes via its conserved C‐terminal WD40 repeat and Q domains, as revealed by crystallographic studies ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]. In certain contexts, TLE1 even acts as a coactivator for nuclear receptors ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "]. In the canonical Wnt pathway the protein is recruited by TCF/LEF transcription factors to maintain target genes in a repressed state, a repression that is overcome when beta‐catenin binds an alternative site on these factors to displace the TLE1 complex ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "]. Moreover, TLE1 interacts with other regulators such as Sirt1—thereby downregulating NF‑κB activity—and it is indispensable for proper neural and pituitary cell fate decisions through its motif‐dependent association with factors like Hes1 ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "]. In addition, studies indicate that phosphorylation events (for example, via Ras–ERK signaling) reduce TLE1’s repressive capacity and promote its nuclear exclusion, thereby fine‐tuning gene expression during development ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncologic settings, aberrant TLE1 expression has emerged both as an important diagnostic biomarker and as an active contributor to tumor cell behavior. Its robust, predominantly nuclear expression has been validated as a highly sensitive marker for synovial sarcoma, helping to distinguish this malignancy from histologically similar soft tissue tumors ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "17"}]}, {"type": "t", "text": "]. Functionally, TLE1 influences tumor cell survival and drug responsiveness; for example, in both synovial sarcoma and acute myeloid leukemia, modulating its levels can alter cell‐cycle arrest and apoptosis ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "20"}]}, {"type": "t", "text": "]. Beyond these, TLE1 fosters oncogenic features in other tumor types: in breast carcinoma it confers resistance to anoikis ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "], and in lung adenocarcinoma it promotes epithelial‐to‐mesenchymal transition via repression of adhesion molecules ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "24"}]}, {"type": "t", "text": "]. TLE1’s diagnostic utility extends to other contexts as well, including its differential expression in cutaneous neoplasms ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "32"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in malignancy, TLE1 is essential to normal cellular differentiation and the integration of signaling networks in diverse tissues. In osteoblastic cells, for instance, TLE1 partners with Runx2 to repress rRNA gene transcription, thereby influencing protein synthesis and cellular proliferation ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "33"}]}, {"type": "t", "text": "]. It also collaborates with factors such as HESX1 to modulate pituitary development, with studies showing that its corepressor function is augmented by related family members in the regulation of endocrine cell fate ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "34"}]}, {"type": "t", "text": "]. TLE1’s influence extends into the maintenance of pancreatic β‑cell identity and the regulation of inflammatory responses, as it has been implicated in preserving β‑cell fate under diabetic conditions and in promoting an anti‑inflammatory macrophage phenotype ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "35", "end_ref": "38"}]}, {"type": "t", "text": "]. Finally, comprehensive reviews reiterate TLE1’s multifaceted roles in embryogenesis, hematopoiesis, and tissue differentiation, highlighting its potential as a therapeutic target in conditions ranging from developmental disorders to cancer ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "39"}]}, {"type": "t", "text": "].\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fei Liu, Yin Liu, Demin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1023/a:1014880813692"}], "href": "https://doi.org/10.1023/a:1014880813692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12030375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12030375"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Laura M Pickles, S Mark Roe, Elizabeth J Hemingway, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0969-2126(02)00768-2"}], "href": "https://doi.org/10.1016/s0969-2126(02"}, {"type": "t", "text": "00768-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12057191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12057191"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Moritz Hentschke, Uwe Borgmeyer "}, {"type": "b", "children": [{"type": "t", "text": "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2003.11.025"}], "href": "https://doi.org/10.1016/j.bbrc.2003.11.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14651967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14651967"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Danette L Daniels, William I Weis "}, {"type": "b", "children": [{"type": "t", "text": "Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb912"}], "href": "https://doi.org/10.1038/nsmb912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15768032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15768032"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hiyaa S Ghosh, James V Spencer, Bobby Ng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20070817"}], "href": "https://doi.org/10.1042/BJ20070817"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17680780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17680780"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Manuel Buscarlet, Alessandro Perin, Adam Laing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M800722200"}], "href": "https://doi.org/10.1074/jbc.M800722200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18611861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18611861"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Cecile Desjobert, Peter Noy, Tracey Swingler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20080872"}], "href": "https://doi.org/10.1042/BJ20080872"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18713067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18713067"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jayanth V Chodaparambil, Kira T Pate, Margretta R D Hepler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular functions of the TLE tetramerization domain in Wnt target gene repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/embj.201387188"}], "href": "https://doi.org/10.1002/embj.201387188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24596249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24596249"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "T Zahavi, A Maimon, T Kushnir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ras-Erk signaling induces phosphorylation of human TLE1 and downregulates its repressor function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.517"}], "href": "https://doi.org/10.1038/onc.2016.517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28192406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28192406"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jefferson Terry, Tsuyoshi Saito, Subbaya Subramanian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/01.pas.0000213330.71745.39"}], "href": "https://doi.org/10.1097/01.pas.0000213330.71745.39"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17255769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17255769"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kemal Kosemehmetoglu, Julie A Vrana, Andrew L Folpe "}, {"type": "b", "children": [{"type": "t", "text": "TLE1 expression is not specific for synovial sarcoma: a whole section study of 163 soft tissue and bone neoplasms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.2009.47"}], "href": "https://doi.org/10.1038/modpathol.2009.47"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19363472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19363472"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Amanda Jagdis, Brian P Rubin, Raymond R Tubbs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prospective evaluation of TLE1 as a diagnostic immunohistochemical marker in synovial sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0b013e3181b7ed36"}], "href": "https://doi.org/10.1097/PAS.0b013e3181b7ed36"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19809272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19809272"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Alfredo L Valente, Jamie Tull, Shengle Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Specificity of TLE1 expression in unclassified high-grade sarcomas for the diagnosis of synovial sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Appl Immunohistochem Mol Morphol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAI.0b013e318279f9ee"}], "href": "https://doi.org/10.1097/PAI.0b013e318279f9ee"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23197007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23197007"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Bharat Rekhi, Ranjan Basak, Sangeeta B Desai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunohistochemical validation of TLE1, a novel marker, for synovial sarcomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Indian J Med Res (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23287123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23287123"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Huei-Chieh Chuang, Sheng-Chi Hsu, Chung-Guei Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reappraisal of TLE-1 immunohistochemical staining and molecular detection of SS18-SSX fusion transcripts for synovial sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Int (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/pin.12113"}], "href": "https://doi.org/10.1111/pin.12113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24422953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24422953"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Lisa M Rooper, Rajni Sharma, Christopher D Gocke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Utility of NKX2.2 and TLE1 Immunohistochemistry in the Differentiation of Ewing Sarcoma and Synovial Sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Appl Immunohistochem Mol Morphol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAI.0000000000000573"}], "href": "https://doi.org/10.1097/PAI.0000000000000573"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28800015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28800015"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sumitra Sivakoti, Shantveer G Uppin, Megha S Uppin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tissue microarray based immunohistochemical study of TLE1 in synovial sarcoma and its histologic mimics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Indian J Pathol Microbiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4103/IJPM.IJPM_425_20"}], "href": "https://doi.org/10.4103/IJPM.IJPM_425_20"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33851625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33851625"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Farshid Dayyani, Jianfeng Wang, Jing-Ruey J Yeh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-07-103291"}], "href": "https://doi.org/10.1182/blood-2007-07-103291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18258796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18258796"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Mario F Fraga, Maria Berdasco, Esteban Ballestar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-0085"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-0085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18519670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18519670"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Sung Wook Seo, Hyewon Lee, Hyun-Il Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of TLE1 in synovial sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jor.21318"}], "href": "https://doi.org/10.1002/jor.21318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21319215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21319215"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Chris Brunquell, Hector Biliran, Scott Jennings, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-12-0144"}], "href": "https://doi.org/10.1158/1541-7786.MCR-12-0144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22952044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22952044"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xin Yao, Shubha Kale Ireland, Tri Pham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TLE1 promotes EMT in A549 lung cancer cells through suppression of E-cadherin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.11.007"}], "href": "https://doi.org/10.1016/j.bbrc.2014.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25446087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25446087"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "I H Bakrin, F A Hussain, S E Tuan Sharif "}, {"type": "b", "children": [{"type": "t", "text": "Transducer-like enhancer of split 1 (TLE1) expression as a diagnostic immunohistochemical marker for synovial sarcoma and its association with morphological features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Malays J Pathol (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27568668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27568668"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xin Yao, Tri Pham, Brandi Temple, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0163228"}], "href": "https://doi.org/10.1371/journal.pone.0163228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27655370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27655370"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Nazan Bozdogan, Gulay B Dilek, Emine Benzer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transducing-Like Enhancer of Split 1: A Potential Immunohistochemical Marker for Glomus Tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Dermatopathol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/DAD.0000000000000705"}], "href": "https://doi.org/10.1097/DAD.0000000000000705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28632567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28632567"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Rola Dali, Federica Verginelli, Albena Pramatarova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of a FOXG1:TLE1 transcriptional network in glioblastoma-initiating cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12168"}], "href": "https://doi.org/10.1002/1878-0261.12168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29316219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29316219"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Victoria Alegría-Landa, Laura Nájera, Dolores Suárez Massa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Primary Subcutaneous Synovial Sarcoma: First Reported Subcutaneous Case Showing TLE1 Immunoreactivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Dermatopathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/DAD.0000000000001172"}], "href": "https://doi.org/10.1097/DAD.0000000000001172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29742555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29742555"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Yuzo Oyama, Haruto Nishida, Takahiro Kusaba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Difference in transducin-like enhancer of split 1 protein expression between basal cell adenomas and basal cell adenocarcinomas - an immunohistochemical study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diagn Pathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13000-018-0726-8"}], "href": "https://doi.org/10.1186/s13000-018-0726-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30053869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30053869"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "María Sol Brassesco, Julia Alejandra Pezuk, Maria Angelica Cortez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TLE1 as an indicator of adverse prognosis in pediatric acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2018.09.010"}], "href": "https://doi.org/10.1016/j.leukres.2018.09.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30286331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30286331"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Travis J Morrell, Yiqin Xiong, April Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of TLE1 in Malignant Melanoma With Spindle Cell Morphology: A Potential Diagnostic Pitfall."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Surg Pathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1066896918805137"}], "href": "https://doi.org/10.1177/1066896918805137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30301396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30301396"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Yiqin Xiong, Karen Dresser, Kristine M Cornejo "}, {"type": "b", "children": [{"type": "t", "text": "Frequent TLE1 Expression in Cutaneous Neoplasms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Dermatopathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/DAD.0000000000001186"}], "href": "https://doi.org/10.1097/DAD.0000000000001186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30608261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30608261"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Salah Aref, Mohamed Sabry El-Ghonemy, Doaa Mohamed Atia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic Value of TLE1 Gene Expression in Patients with T-cell Acute Lymphoblastic Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31557/APJCP.2021.22.5.1653"}], "href": "https://doi.org/10.31557/APJCP.2021.22.5.1653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34048198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34048198"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Syed A Ali, Sayyed K Zaidi, Jason R Dobson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1000620107"}], "href": "https://doi.org/10.1073/pnas.1000620107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20160071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20160071"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Luciani R Carvalho, Michelle L Brinkmeier, Frederic Castinetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Corepressors TLE1 and TLE3 interact with HESX1 and PROP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2008-0359"}], "href": "https://doi.org/10.1210/me.2008-0359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20181723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20181723"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "David E Metzger, Chengyang Liu, Amin Sam Ziaie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db13-0867"}], "href": "https://doi.org/10.2337/db13-0867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24487024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24487024"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Federica De Paoli, Corinne Copin, Jonathan Vanhoutte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transducin-like enhancer of split-1 is expressed and functional in human macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.12029"}], "href": "https://doi.org/10.1002/1873-3468.12029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26763127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26763127"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Mara Cavallin, Camille Maillard, Marie Hully, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TLE1, a key player in neurogenesis, a new candidate gene for autosomal recessive postnatal microcephaly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2018.05.002"}], "href": "https://doi.org/10.1016/j.ejmg.2018.05.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29758293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29758293"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Sarah L Armour, Scott J Anderson, Sarah J Richardson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced Expression of the Co-regulator TLE1 in Type 2 Diabetes Is Associated with Increased Islet α-Cell Number."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/endocr/bqaa011"}], "href": "https://doi.org/10.1210/endocr/bqaa011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32065829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32065829"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Karen Pinto, Runjan Chetty "}, {"type": "b", "children": [{"type": "t", "text": "Gene of the month: "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TLE 1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Pathol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jclinpath-2020-207174"}], "href": "https://doi.org/10.1136/jclinpath-2020-207174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33441390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33441390"}]}]}]}