TLN2 Gene

Name	talin 2
Description	This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTalin‐2 (TLN2) is emerging as a critical mediator of cell adhesion by linking integrins to the actin cytoskeleton. Detailed biochemical and structural studies have revealed that TLN2 contains a conserved I/LWEQ module with cryptic actin‐binding determinants and a unique F0–F1–F2 arrangement that governs its association with phospholipid‐rich membranes. These features underlie TLN2’s ability to modulate integrin activation and to coordinate focal adhesion formation, as evidenced by its remarkably strong binding to certain β‐integrin tails in striated muscle and other cell types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its structural roles in adhesion, TLN2 has been implicated in cancer cell invasion and metastasis. In invasive carcinoma models, TLN2 is required for the generation of traction force and for invadopodia formation through its potent interaction with β‐integrin tails that, when disrupted, impairs matrix degradation. Moreover, altered TLN2 expression has been noted in hepatocellular carcinoma as well as in breast tissue in association with hormonal changes and microRNA regulation, underscoring its importance in tumor cell migration and metastatic progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTLN2 also plays a pivotal role in the maintenance of cardiac and neural integrity. In the heart, TLN2 is the predominant isoform in mature cardiomyocytes, localizing to costameres and intercalated disks where it supports stable adhesion and proper mechanotransduction; its dysregulation has been linked to adverse cardiac remodeling and cardiomyopathy. In neurological settings, altered expression of TLN2 has been observed in epilepsy, and pathogenic missense mutations in TLN2 have been associated with congenital limb anomalies such as camptodactyly – suggesting that precise TLN2 function is crucial for both muscle and neuronal development and homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional layers of TLN2 regulation arise from its interaction with key binding partners that fine‐tune focal adhesion dynamics and mechanotransduction. TLN2 functions in concert with proteins such as vinculin and the KANK family to orchestrate the linkage between integrins and the actomyosin network, ensuring proper signal transduction and cytoskeletal remodeling. These interactions not only influence the lipid‐dependent recruitment of TLN2 to membranes but also modulate its capacity to drive adhesion complex maturation, thereby impacting cellular responses to mechanical stimuli."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Melissa A Senetar, Stanley J Foster, Richard O McCann "}, {"type": "b", "children": [{"type": "t", "text": "Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi0487239"}], "href": "https://doi.org/10.1021/bi0487239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15581353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15581353"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Melissa A Senetar, Carole L Moncman, Richard O McCann "}, {"type": "b", "children": [{"type": "t", "text": "Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Motil Cytoskeleton (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cm.20173"}], "href": "https://doi.org/10.1002/cm.20173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17183545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17183545"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nicholas J Anthis, Kate L Wegener, David R Critchley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural diversity in integrin/talin interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2010.09.018"}], "href": "https://doi.org/10.1016/j.str.2010.09.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21134644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21134644"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ana Maria Manso, Ruixia Li, Susan J Monkley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.427484"}], "href": "https://doi.org/10.1074/jbc.M112.427484"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23266827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23266827"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Elena S Gusareva, Jean-Claude Twizere, Kristel Sleegers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2018.08.001"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2018.08.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30201328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30201328"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Erumbi S Rangarajan, Marina C Primi, Lesley A Colgan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A distinct talin2 structure directs isoform specificity in cell adhesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.010789"}], "href": "https://doi.org/10.1074/jbc.RA119.010789"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32605925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32605925"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Vilde D Haakensen, Trine Bjøro, Torben Lüders, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-11-332"}], "href": "https://doi.org/10.1186/1471-2407-11-332"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21812955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21812955"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kun-Peng Fang, Wei Dai, Yan-Hong Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-016-2076-9"}], "href": "https://doi.org/10.1186/s12885-016-2076-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26822056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26822056"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lei Qi, Naser Jafari, Xiang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Talin2-mediated traction force drives matrix degradation and cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.185959"}], "href": "https://doi.org/10.1242/jcs.185959"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27694340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27694340"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zbigniew Baster, Liqing Li, Zenon Rajfur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Talin2 mediates secretion and trafficking of matrix metallopeptidase 9 during invadopodium formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2020.118693"}], "href": "https://doi.org/10.1016/j.bbamcr.2020.118693"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32198023"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32198023"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "P Gao, H Zhu, W Pei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression of miR-4324 and its targeted gene Talin2 in breast cancer]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2022.10.11"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2022.10.11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36329586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36329586"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Fei Xiao, Dan Chen, Yang Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2008.12.008"}], "href": "https://doi.org/10.1016/j.brainres.2008.12.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19109932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19109932"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Alice Zemljic-Harpf, Ana Maria Manso, Robert S Ross "}, {"type": "b", "children": [{"type": "t", "text": "Vinculin and talin: focus on the myocardium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Investig Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2310/JIM.0b013e3181c5e074"}], "href": "https://doi.org/10.2310/JIM.0b013e3181c5e074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19952892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19952892"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zheng Xiao, Lan Shen, Dan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Talin 2 concentrations in cerebrospinal fluid in patients with epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Biochem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinbiochem.2010.06.015"}], "href": "https://doi.org/10.1016/j.clinbiochem.2010.06.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20620133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20620133"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hao Deng, Sheng Deng, Hongbo Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome Sequencing of a Pedigree Reveals S339L Mutation in the TLN2 Gene as a Cause of Fifth Finger Camptodactyly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0155180"}], "href": "https://doi.org/10.1371/journal.pone.0155180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27223613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27223613"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Gilbert Di Paolo, Lorenzo Pellegrini, Kresimir Letinic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature01147"}], "href": "https://doi.org/10.1038/nature01147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12422219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12422219"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Suman Yadav Nanda, Thuy Hoang, Priya Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vinculin regulates assembly of talin: β3 integrin complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.24772"}], "href": "https://doi.org/10.1002/jcb.24772"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24446374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24446374"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Magdaléna von Essen, Rolle Rahikainen, Niku Oksala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Atherosclerosis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.atherosclerosis.2016.10.031"}], "href": "https://doi.org/10.1016/j.atherosclerosis.2016.10.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27816808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27816808"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Charlotte F Kelley, Thomas Litschel, Stephanie Schumacher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.56110"}], "href": "https://doi.org/10.7554/eLife.56110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32657269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32657269"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Marija Lončarić, Nikolina Stojanović, Anja Rac-Justament, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-023-00473-6"}], "href": "https://doi.org/10.1186/s11658-023-00473-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37460977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37460977"}]}]}]}
Proteins	TLN2_HUMAN
NCBI Gene ID	83660
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TLN2 has 8,282 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 127 datasets.

Click the + buttons to view associations for TLN2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TLN2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TLN2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TLN2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TLN2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TLN2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TLN2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TLN2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TLN2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TLN2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TLN2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TLN2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TLN2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TLN2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TLN2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TLN2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TLN2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TLN2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TLN2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TLN2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TLN2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TLN2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TLN2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TLN2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TLN2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TLN2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TLN2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TLN2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TLN2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TLN2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TLN2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TLN2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TLN2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TLN2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TLN2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TLN2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TLN2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TLN2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TLN2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TLN2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TLN2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with TLN2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.