TMED10 Gene

Name	transmembrane emp24-like trafficking protein 10 (yeast)
Description	This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTMED10, also known as TMP21 or p23, is a member of the p24 cargo protein family that plays a multifaceted role in intracellular protein trafficking. It is a component of high‐molecular‐weight complexes in the endoplasmic reticulum–Golgi network and part of the presenilin complex, thereby influencing the processing of type I transmembrane proteins. In addition, TMED10 has been shown to interact with major histocompatibility complex class I molecules, implicating it in diverse transport and quality‐control mechanisms."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA large body of work has focused on the role of TMED10 in modulating proteolytic processing via the γ‐secretase complex and its implications for Alzheimer’s disease. TMED10 associates with the presenilin complex and selectively regulates γ‐secretase cleavage of substrates such as the amyloid precursor protein without perturbing ε–secretase activity, thereby limiting the production of amyloid‐β peptides. Alterations in TMED10 expression and genetic variants that promote increased splicing efficiency have been linked to enhanced amyloidogenic processing, suggesting that TMED10 acts as a negative regulator whose deficiency may contribute to Alzheimer’s pathology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in proteolytic processing, TMED10 also influences other key cellular pathways. Studies indicate that TMED10 acts as a negative regulator of autophagy by directly binding the protease ATG4B—thereby attenuating LC3 processing—and modulating reactive oxygen species production and mTOR signaling. In parallel, TMED10 disrupts the formation of TGF‐β receptor complexes, reducing downstream Smad phosphorylation and transcriptional responses that contribute to tumor growth. Its function further extends to host‐pathogen interactions: TMED10 is critical for virus‐induced plasma membrane blebbing and macropinocytosis during vaccinia virus infection and serves as a binding partner for bacterial effectors that modulate protein trafficking. Intriguingly, a genome‐wide scan has also identified variants in the TMED10 locus as determinants of human skeletal growth and adult stature."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fusheng Chen, Hiroshi Hasegawa, Gerold Schmitt-Ulms, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature04667"}], "href": "https://doi.org/10.1038/nature04667"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16641999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16641999"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Raphaëlle Pardossi-Piquard, Christopher Böhm, Fusheng Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TMP21 transmembrane domain regulates gamma-secretase cleavage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.059345"}], "href": "https://doi.org/10.1074/jbc.M109.059345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19710022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19710022"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Youngsoo Jun, Kwangseog Ahn "}, {"type": "b", "children": [{"type": "t", "text": "Tmp21, a novel MHC-I interacting protein, preferentially binds to Β2-microglobulin-free MHC-I heavy chains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMB Rep (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5483/BMBRep.2011.44.6.369"}], "href": "https://doi.org/10.5483/BMBRep.2011.44.6.369"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21699748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21699748"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Virginia Dolcini, Julie Dunys, Jean Sevalle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.03.151"}], "href": "https://doi.org/10.1016/j.bbrc.2008.03.151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18405662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18405662"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kelley Bromley-Brits, Weihong Song "}, {"type": "b", "children": [{"type": "t", "text": "The role of TMP21 in trafficking and amyloid-β precursor protein (APP) processing in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Alzheimer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/156720512800492521"}], "href": "https://doi.org/10.2174/156720512800492521"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22299712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22299712"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaojie Zhang, Yili Wu, Fang Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Alzheimer-Associated SNP in Tmp21 Increases Amyloidogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-017-0459-9"}], "href": "https://doi.org/10.1007/s12035-017-0459-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28233271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28233271"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Shengchun Liu, Kelley Bromley-Brits, Kun Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TMP21 degradation is mediated by the ubiquitin-proteasome pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1460-9568.2008.06497.x"}], "href": "https://doi.org/10.1111/j.1460-9568.2008.06497.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19046380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19046380"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ji Hyun Shin, So Jung Park, Doo Sin Jo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2019.1586249"}], "href": "https://doi.org/10.1080/15548627.2019.1586249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30821607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30821607"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ji Hyun Shin, Dong-Hyung Cho "}, {"type": "b", "children": [{"type": "t", "text": "TMP21 regulates autophagy by modulating ROS production and mTOR activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.08.125"}], "href": "https://doi.org/10.1016/j.bbrc.2019.08.125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31472964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31472964"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Naoko Nakano, Yuki Tsuchiya, Kenro Kako, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.769109"}], "href": "https://doi.org/10.1074/jbc.M116.769109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28115518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28115518"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Rutger D Luteijn, Ferdy van Diemen, Vincent A Blomen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02160-18"}], "href": "https://doi.org/10.1128/JVI.02160-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30996093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30996093"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rachel L Olsen, Frank Echtenkamp, Dilyara Cheranova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The enterohemorrhagic Escherichia coli effector protein NleF binds mammalian Tmp21."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Vet Microbiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.vetmic.2013.01.028"}], "href": "https://doi.org/10.1016/j.vetmic.2013.01.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23434013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23434013"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Nicole Soranzo, Fernando Rivadeneira, Usha Chinappen-Horsley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000445"}], "href": "https://doi.org/10.1371/journal.pgen.1000445"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19343178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19343178"}]}]}]}
Synonyms	P24(DELTA), S31III125, TMP-21-I, TMP21, p24d1, S31I125
Proteins	TMEDA_HUMAN
NCBI Gene ID	10972
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TMED10 has 10,058 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 123 datasets.

Click the + buttons to view associations for TMED10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TMED10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TMED10 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TMED10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TMED10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TMED10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TMED10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TMED10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TMED10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TMED10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TMED10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TMED10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TMED10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TMED10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TMED10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TMED10 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TMED10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TMED10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TMED10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TMED10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TMED10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TMED10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TMED10 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TMED10 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TMED10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TMED10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TMED10 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TMED10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TMED10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TMED10 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TMED10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TMED10 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TMED10 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TMED10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TMED10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TMED10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TMED10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TMED10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TMED10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TMED10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TMED10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TMED10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.