TMEM198B Gene

Name transmembrane protein 198B, pseudogene
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTMEM198B, a pseudogene transmembrane protein highly expressed in glioma tissues and cell lines, plays a crucial role in driving the malignant progression of glioma. Its overexpression enhances the reprogramming of lipid metabolism, thereby promoting increased de novo lipogenesis and fatty acid elongation via upregulation of key metabolic enzymes such as ACLY and ELOVL6. Simultaneously, TMEM198B contributes to remodeling the tumor immune microenvironment by indirectly inducing immunosuppressive conditions, which facilitate tumor immune escape."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, TMEM198B exerts its oncogenic function by binding to SETD1B to mediate the tri-methylation of histone H3 on lysine 4 (H3K4me3) at the promoter region of the transcription factor PLAGL2, thereby enhancing its expression. Upregulated PLAGL2 in turn transcriptionally activates metabolic genes such as ACLY and ELOVL6, reinforcing lipid biosynthesis pathways. Additionally, TMEM198B facilitates the loading of these oncogenic signals into glioma-derived exosomes, which promote lipid accumulation and fatty acid oxidation in macrophages, leading to their M2 polarization and further contributing to an immunosuppressive microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ying Zhan, Wei Qiao, Bolong Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual role of pseudogene TMEM198B in promoting lipid metabolism and immune escape of glioma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-022-02445-0"}], "href": "https://doi.org/10.1038/s41388-022-02445-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36038663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36038663"}]}]}]}
NCBI Gene ID 440104
API
Download Associations
Predicted Functions View TMEM198B's ARCHS4 Predicted Functions.
Co-expressed Genes View TMEM198B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View TMEM198B's ARCHS4 Predicted Functions.

Functional Associations

TMEM198B has 2,269 functional associations with biological entities spanning 7 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 23 datasets.

Click the + buttons to view associations for TMEM198B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of TMEM198B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of TMEM198B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of TMEM198B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of TMEM198B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of TMEM198B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with TMEM198B gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of TMEM198B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of TMEM198B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at TMEM198B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of TMEM198B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of TMEM198B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of TMEM198B gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of TMEM198B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of TMEM198B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of TMEM198B gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of TMEM198B gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of TMEM198B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of TMEM198B gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of TMEM198B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of TMEM198B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain TMEM198B protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by TMEM198B gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at TMEM198B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.