{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies provided focuses squarely on the multifunctional guidance cue netrin‐1 and its signaling pathways in diverse biological contexts—including axon guidance, inflammation, angiogenesis, cell survival, and tissue remodeling. Netrin‐1 is shown to regulate the migration and retention of immune cells in atherosclerotic plaques and adipose tissue, to modulate axonal pathfinding through its interactions with receptors such as DCC, UNC5 family members, and even CD146, and to control apoptotic and trophic signaling in both developing and injured tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional reports illuminate netrin‐1’s role in angiogenesis and tissue repair, demonstrating that its interactions with various receptors (for example, neogenin and CD146) can yield either attractive or repulsive outcomes. Genetic deletion or functional inhibition of netrin‐1 in animal models alters not only neurodevelopment—as seen in commissural and thalamocortical axon guidance—but also the regulation of inflammatory responses and extracellular matrix remodeling in cardiovascular and renal pathologies. These works emphasize that netrin‐1 functions as a context‐dependent cue operating through multiple intracellular signaling cascades such as Rac1, ERK1/2, and STAT3."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is important to note that none of the abstracts provided mention or investigate the transmembrane protein TMEM205. Although TMEM205 has been characterized in other contexts (for example, in relation to chemoresistance mechanisms), the body of work summarized here does not provide any data regarding its function. Thus, while these studies offer comprehensive insights into netrin‐1 signaling and its physiological roles in development and disease, they do not shed light on any role for TMEM205. For completeness, the remaining studies"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "44"}]}, {"type": "t", "text": "does not alter this conclusion.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan Jiang, Min-tsai Liu, Michael D Gershon "}, {"type": "b", "children": [{"type": "t", "text": "Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0012-1606(03)00136-2"}], "href": "https://doi.org/10.1016/s0012-1606(03"}, {"type": "t", "text": "00136-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12798294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12798294"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Julien Fitamant, Céline Guenebeaud, Marie-May Coissieux, et al. 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