TMEM253 Gene

Name	transmembrane protein 253
Synonyms	C14ORF176, C14ORF95, NCRNA00220
Proteins	TM253_HUMAN
NCBI Gene ID	643382
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TMEM253 has 2,337 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 37 datasets.

Click the + buttons to view associations for TMEM253 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TMEM253 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TMEM253 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TMEM253 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TMEM253 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TMEM253 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TMEM253 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TMEM253 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TMEM253 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TMEM253 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TMEM253 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TMEM253 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TMEM253 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TMEM253 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TMEM253 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TMEM253 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of TMEM253 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of TMEM253 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GO Cellular Component Annotations 2015	cellular components containing TMEM253 protein from the curated GO Cellular Component Annotations 2015 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of TMEM253 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of TMEM253 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TMEM253 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	GWASdb SNP-Phenotype Associations	phenotypes associated with TMEM253 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
	HPA Cell Line Gene Expression Profiles	cell lines with high or low expression of TMEM253 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
	HPA Tissue Gene Expression Profiles	tissues with high or low expression of TMEM253 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
	HPA Tissue Protein Expression Profiles	tissues with high or low expression of TMEM253 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
	HPA Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TMEM253 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of TMEM253 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of TMEM253 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	cell lines with high or low expression of TMEM253 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
	LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain TMEM253 protein from the LOCATE Predicted Protein Localization Annotations dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of TMEM253 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	Pathway Commons Protein-Protein Interactions	interacting proteins for TMEM253 from the Pathway Commons Protein-Protein Interactions dataset.
	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TMEM253 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
	Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TMEM253 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
	Tabula Sapiens Gene-Cell Associations	cell types with high or low expression of TMEM253 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
	TargetScan Predicted Conserved microRNA Targets	microRNAs regulating expression of TMEM253 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
	TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of TMEM253 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
	TCGA Signatures of Differentially Expressed Genes for Tumors	tissue samples with high or low expression of TMEM253 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.