{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts explicitly mention TMEM35A, a common picture emerges from these studies regarding transcription‐regulatory proteins (notably TEF/TEAD family members) that serve as key effectors of the Hippo pathway and other signal transduction cascades. Collectively, these reports describe how TEF/TEAD factors and their binding partners (e.g., YAP, TAZ, and Vgl/VITO proteins) are essential for directing diverse cellular programs such as cell proliferation, differentiation, survival, and metabolic control in tissues including cardiac and skeletal muscle, vascular smooth muscle, neural and glial lineages, and even in fibroblasts during tissue remodeling. For instance, several studies demonstrate that TEAD1 cooperates with co‐activators like YAP/TAZ to modulate gene expression programs that govern cardiomyocyte cell cycle progression and mitochondrial function, while others identify similar roles in regulating muscle‐specific gene expression and myogenic differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThese integrated findings imply that, by analogy, TMEM35A—if functionally linked to similar transcription‐regulatory networks—might act as a modulatory protein that influences gene expression programs governing energy metabolism, cell cycle control, and tissue remodeling. For example, insights into TEAD1’s roles in mediating mitochondrial oxidative phosphorylation, regulating cardiac hypertrophy and fibrosis, and even influencing cellular senescence"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "26"}, {"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "—offer a conceptual framework for exploring TMEM35A’s potential biological roles. Future investigations will need to determine whether TMEM35A directly interacts with these pathways or serves an ancillary function that fine‐tunes transcriptional responses elicited by TEAD/TEF complexes.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J H Xiao, I Davidson, H Matthes, et al. 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