{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA careful review of the provided literature (‐"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "reveals an extensive focus on chemokine-mediated cellular trafficking and activation—particularly highlighting the role of CXCR3 and its ligands in coordinating immune cell recruitment, effector function, and resolution of inflammation in contexts ranging from cancer immunotherapy and autoimmunity to infectious and central nervous system disorders. Notably, however, none of these studies specifically address or mention TMEM92. In contrast, they collectively underscore mechanisms by which extracellular chemoattractants modulate immune responses and tissue remodeling."}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFor example, several investigations detail how CXCR3 signaling directs the migration of T lymphocytes, natural killer cells, and other leukocytes into tumors or inflamed tissues—thereby influencing clinical outcomes in cancer, autoimmune diseases, and even wound repair."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "17"}]}, {"type": "t", "text": " These reports dissect post‐translational chemokine modification, receptor internalization, and the fine regulation of effector versus memory T cell fates—all of which contribute to a nuanced understanding of chemokine biology in health and disease."}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther mechanistic studies extend these insights by examining receptor–ligand selectivity, intracellular signaling cascades, and how chemokine signals are integrated to control immune cell positioning in diverse tissue microenvironments."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "27"}]}, {"type": "t", "text": " In aggregate, while these studies richly characterize chemokine receptor systems (notably CXCR3) and their critical immunomodulatory roles, none provide evidence regarding the function or involvement of TMEM92. As such, the literature surveyed here does not offer direct insights into TMEM92’s biological role; future research is therefore needed to determine whether TMEM92 might interact with, modulate, or be regulated by similar chemokine‐driven pathways in immune or other cellular contexts."}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Melvyn T Chow, Aleksandra J Ozga, Rachel L Servis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2019.04.010"}], "href": "https://doi.org/10.1016/j.immuni.2019.04.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31097342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31097342"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "M E Mikucki, D T Fisher, J Matsuzaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms8458"}], "href": "https://doi.org/10.1038/ncomms8458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26109379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26109379"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Karen M Lammers, Ruliang Lu, Julie Brownley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2008.03.023"}], "href": "https://doi.org/10.1053/j.gastro.2008.03.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18485912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18485912"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marco Wendel, Ioanna E Galani, Elisabeth Suri-Payer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-1440"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-1440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18922917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18922917"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dianhua Jiang, Jiurong Liang, Jennifer Hodge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of pulmonary fibrosis by chemokine receptor CXCR3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI16861"}], "href": "https://doi.org/10.1172/JCI16861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15254596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15254596"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gabriele S V Campanella, Andrew M Tager, Joseph K El Khoury, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0801544105"}], "href": "https://doi.org/10.1073/pnas.0801544105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18347328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18347328"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Rosa Barreira da Silva, Melissa E Laird, Nader Yatim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.3201"}], "href": "https://doi.org/10.1038/ni.3201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26075911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26075911"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tessa Bergsbaken, Michael J Bevan "}, {"type": "b", "children": [{"type": "t", "text": "Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8⁺ T cells responding to infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.3108"}], "href": "https://doi.org/10.1038/ni.3108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25706747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25706747"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Angelika Rappert, Ingo Bechmann, Tatyana Pivneva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2451-04.2004"}], "href": "https://doi.org/10.1523/JNEUROSCI.2451-04.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15456824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15456824"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "John A Belperio, Michael P Keane, Marie D Burdick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.169.2.1037"}], "href": "https://doi.org/10.4049/jimmunol.169.2.1037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12097412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12097412"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Bram Slütter, Lecia L Pewe, Susan M Kaech, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2013.09.013"}], "href": "https://doi.org/10.1016/j.immuni.2013.09.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24238342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24238342"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Marcus Müller, Sally L Carter, Markus J Hofer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCR3 signaling reduces the severity of experimental autoimmune encephalomyelitis by controlling the parenchymal distribution of effector and regulatory T cells in the central nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.179.5.2774"}], "href": "https://doi.org/10.4049/jimmunol.179.5.2774"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17709491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17709491"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Heather D Hickman, Glennys V Reynoso, Barbara F Ngudiankama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2015.02.009"}], "href": "https://doi.org/10.1016/j.immuni.2015.02.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25769612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25769612"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Makoto Kurachi, Junko Kurachi, Fumiko Suenaga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20102101"}], "href": "https://doi.org/10.1084/jem.20102101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21788406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21788406"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Urs Christen, Dorian B McGavern, Andrew D Luster, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.171.12.6838"}], "href": "https://doi.org/10.4049/jimmunol.171.12.6838"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14662890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14662890"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yoshihisa Okamoto, Eduardo J Folco, Manabu Minami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.107.164988"}], "href": "https://doi.org/10.1161/CIRCRESAHA.107.164988"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17991878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17991878"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ye Htun Oo, Vanessa Banz, Dean Kavanagh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2012.07.008"}], "href": "https://doi.org/10.1016/j.jhep.2012.07.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22796894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22796894"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jenny H Xie, Naomi Nomura, Min Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.1102573"}], "href": "https://doi.org/10.1189/jlb.1102573"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12773510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12773510"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Bo Zhang, Ying Kai Chan, Bao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.180.4.2641"}], "href": "https://doi.org/10.4049/jimmunol.180.4.2641"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18250476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18250476"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Liping Liu, Deren Huang, Masaru Matsui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Severe disease, unaltered leukocyte migration, and reduced IFN-gamma production in CXCR3-/- mice with experimental autoimmune encephalomyelitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.176.7.4399"}], "href": "https://doi.org/10.4049/jimmunol.176.7.4399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16547278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16547278"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Cecelia C Yates, Diana Whaley, Priya Kulasekeran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2007.061092"}], "href": "https://doi.org/10.2353/ajpath.2007.061092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17600132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17600132"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Richard J Bodnar, Cecelia C Yates, Margaret E Rodgers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IP-10 induces dissociation of newly formed blood vessels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.048793"}], "href": "https://doi.org/10.1242/jcs.048793"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19470579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19470579"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Andrea Meiser, Anja Mueller, Emma L Wise, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.180.10.6713"}], "href": "https://doi.org/10.4049/jimmunol.180.10.6713"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18453591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18453591"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jacob E Kohlmeier, Tres Cookenham, Shannon C Miller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0902022"}], "href": "https://doi.org/10.4049/jimmunol.0902022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19734208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19734208"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Gabriele S V Campanella, Richard A Colvin, Andrew D Luster "}, {"type": "b", "children": [{"type": "t", "text": "CXCL10 can inhibit endothelial cell proliferation independently of CXCR3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0012700"}], "href": "https://doi.org/10.1371/journal.pone.0012700"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20856926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20856926"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Chanyu Yue, Shudan Shen, Jiehui Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAT3 in CD8+ T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Immunol Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2326-6066.CIR-15-0014"}], "href": "https://doi.org/10.1158/2326-6066.CIR-15-0014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26025380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26025380"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Georgina Xanthou, Timothy J Williams, James E Pease "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200324235"}], "href": "https://doi.org/10.1002/eji.200324235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14515277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14515277"}]}]}]}