TMEM94 Gene

Name	transmembrane protein 94
Description	Enables P-type magnesium transporter activity. Involved in magnesium ion transport from cytosol to endoplasmic reticulum. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTMEM94, also known as ERMA, is an endoplasmic reticulum‐localized multi‐pass transmembrane protein that plays a critical role in intracellular magnesium (Mg2+) homeostasis. Structural predictions and biochemical evidence indicate that TMEM94 uniquely combines a P‐type ATPase domain with a GMN motif, enabling efficient ERMg2+ uptake. The protein features a large cytosolic actuator headpiece along with nucleotide-binding and phosphorylation domains, akin to both prokaryotic (e.g., mgtA and mgtB) and eukaryotic Mg2+ ATPases, and a key tyrosine residue is essential for its Mg2+ binding and transport activity. Dysfunction of this system, as demonstrated by haploinsufficiency and impaired Ca2+ cycling in cardiomyocytes, underlines its importance for normal cardiac physiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "TMEM94 also holds significant clinical relevance; biallelic pathogenic variants in this gene have been linked to a syndromic disorder characterized by intellectual developmental delay, congenital cardiac malformations, and distinct dysmorphic facial features. This association highlights TMEM94’s essential role not only in cellular ion regulation but also in normal human development, with disruptions leading to multiple organ system pathologies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Neelanjan Vishnu, Manigandan Venkatesan, Travis R Madaris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ERMA (TMEM94) is a P-type ATPase transporter for Mg[2+] uptake in the endoplasmic reticulum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2024.02.033"}], "href": "https://doi.org/10.1016/j.molcel.2024.02.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38513662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38513662"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mohamed H Al-Hamed, Nada Alsahan, Maha Tulbah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fetal Anomalies Associated with Novel Pathogenic Variants in TMEM94."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes11090967"}], "href": "https://doi.org/10.3390/genes11090967"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32825426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32825426"}]}]}]}
NCBI Gene ID	9772
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TMEM94 has 1,955 functional associations with biological entities spanning 6 categories (chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 36 datasets.

Click the + buttons to view associations for TMEM94 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TMEM94 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TMEM94 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TMEM94 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TMEM94 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TMEM94 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TMEM94 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TMEM94 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TMEM94 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TMEM94 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TMEM94 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TMEM94 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TMEM94 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TMEM94 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TMEM94 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TMEM94 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TMEM94 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	GO Biological Process Annotations 2025	biological processes involving TMEM94 gene from the curated GO Biological Process Annotations2025 dataset.
	GO Cellular Component Annotations 2025	cellular components containing TMEM94 protein from the curated GO Cellular Component Annotations 2025 dataset.
	GO Molecular Function Annotations 2025	molecular functions performed by TMEM94 gene from the curated GO Molecular Function Annotations 2025 dataset.
	GTEx eQTL 2025	SNPs regulating expression of TMEM94 gene from the GTEx eQTL 2025 dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of TMEM94 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	GWAS Catalog SNP-Phenotype Associations 2025	phenotypes associated with TMEM94 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of TMEM94 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Mouse Transcription Factor Targets 2025	transcription factors regulating expression of TMEM94 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	small molecule perturbations changing expression of TMEM94 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
	MGI Mouse Phenotype Associations 2023	phenotypes of transgenic mice caused by TMEM94 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	drug perturbations changing expression of TMEM94 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of TMEM94 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of TMEM94 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of TMEM94 gene from the Rummagene Transcription Factor Associations 2026 dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of TMEM94 gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of TMEM94 gene from the RummaGEO Gene Perturbation Signatures dataset.
	Sci-Plex Drug Perturbation Signatures	drug perturbations changing expression of TMEM94 gene from the Sci-Plex Drug Perturbation Signatures dataset.
	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	drug perturbations changing expression of TMEM94 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	tissues with high expression of TMEM94 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	tissues with high expression of TMEM94 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with TMEM94 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.