{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the query asks about TMPRSS12, none of the provided abstracts address this transmembrane serine protease. Instead, the collective studies focus on a different but equally multifaceted family of proteins—the RNA‐ and DNA‐binding proteins known as translin (also called testis brain RNA-binding protein or TB-RBP) and its partner TRAX. These proteins are shown to orchestrate posttranscriptional regulation in several cell types. In neuronal cells, for example, translin–TRAX complexes regulate the transport and local translation of messenger RNAs (such as brain-derived neurotrophic factor mRNA), thereby contributing to synaptic plasticity, learning, memory, and behavior."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn reproductive tissues and other somatic contexts, these RNA-binding proteins also play critical roles. They regulate the stability, transport, and timely translation of mRNAs required for proper spermatogenesis and germ cell development, are involved in microRNA degradation that modulates gene expression dynamics, and even influence cellular proliferation and differentiation. The studies detail how translin not only helps in the posttranscriptional control of testis-specific transcripts, but also modulates cellular responses such as DNA repair, metabolic regulation, and aspects of neural function—processes that are fundamental for normal cell physiology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "12"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations reveal that the translin–TRAX complex impacts microRNA homeostasis and is particularly involved in reversing translational silencing at activated synapses as well as modulating transcriptional responses in specific cell types. These functions have implications in neuropsychiatric disorders, cancer biology, vascular physiology, and mesenchymal cell growth. Overall, the data underscore that while the provided literature richly characterizes the multifunctional roles of translin, TB-RBP, and TRAX in RNA metabolism and cell regulation, they do not contain any information regarding the function of TMPRSS12."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "V M Chennathukuzhi, Y Kurihara, J D Bray, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Testis brain ribonucleic acid-binding protein/translin possesses both single-stranded and double-stranded ribonuclease activities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi048847l"}], "href": "https://doi.org/10.1021/bi048847l"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15491149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15491149"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yoon Shin Cho, Naoko Iguchi, Juxiang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meiotic messenger RNA and noncoding RNA targets of the RNA-binding protein Translin (TSN) in mouse testis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.105.042788"}], "href": "https://doi.org/10.1095/biolreprod.105.042788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15987823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15987823"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Synthia H Mellon, Susanna R Bair, Christophe Depoix, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translin coactivates steroidogenic factor-1-stimulated transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2005-0355"}], "href": "https://doi.org/10.1210/me.2005-0355"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17053042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17053042"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yuko Fukuda, Reiko Ishida, Katsunori Aoki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Contribution of Translin to hematopoietic regeneration after sublethal ionizing irradiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Pharm Bull (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1248/bpb.31.207"}], "href": "https://doi.org/10.1248/bpb.31.207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18239274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18239274"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Zuoren Yu, Norman B Hecht "}, {"type": "b", "children": [{"type": "t", "text": "The DNA/RNA-binding protein, translin, binds microRNA122a and increases its in vivo stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Androl (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2164/jandrol.108.005090"}], "href": "https://doi.org/10.2164/jandrol.108.005090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18567644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18567644"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "C Chiaruttini, A Vicario, Z Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0902833106"}], "href": "https://doi.org/10.1073/pnas.0902833106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19805324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19805324"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Matthew Lluis, Warren Hoe, Jennifer Schleit, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of nucleic acid binding by a recombinant translin-trax complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.04.166"}], "href": "https://doi.org/10.1016/j.bbrc.2010.04.166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20450889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20450889"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yen-Ching Wu, Rebecca Williamson, Zhi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2010.07166.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2010.07166.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21198640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21198640"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ken Asada, Emanuele Canestrari, Xiuping Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rescuing dicer defects via inhibition of an anti-dicing nuclease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2014.10.021"}], "href": "https://doi.org/10.1016/j.celrep.2014.10.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25457613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25457613"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Alan Jung Park, Robbert Havekes, Xiuping Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Learning induces the translin/trax RNase complex to express activin receptors for persistent memory."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.27872"}], "href": "https://doi.org/10.7554/eLife.27872"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28927503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28927503"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yukiko Ikeuchi, Azusa Imanishi, Katsuko Sudo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translin modulates mesenchymal cell proliferation and differentiation in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.08.141"}], "href": "https://doi.org/10.1016/j.bbrc.2018.08.141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30172368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30172368"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Aparna P Shah, Miranda D Johnson, Xiuping Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Obes (Lond) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41366-018-0315-7"}], "href": "https://doi.org/10.1038/s41366-018-0315-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30647452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30647452"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Eric Tuday, Yohei Nomura, Deepa Ruhela, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.00153.2019"}], "href": "https://doi.org/10.1152/ajpheart.00153.2019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31625778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31625778"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Leo Matsubara, Tomoya Fukuoka, Katsuko Sudo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translin restricts the growth of pubertal mammary epithelial cells estrogen-independently in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.10.176"}], "href": "https://doi.org/10.1016/j.bbrc.2019.10.176"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31677798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31677798"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xiuping Fu, Aparna P Shah, Zhi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Metab (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molmet.2020.101013"}], "href": "https://doi.org/10.1016/j.molmet.2020.101013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32408014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32408014"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Alan Jung Park, Mahesh Shivarama Shetty, Jay M Baraban, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Brain (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13041-020-00691-5"}], "href": "https://doi.org/10.1186/s13041-020-00691-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33172471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33172471"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Kanako Oyama, Tadashi Baba, Shin-Ichi Kashiwabara "}, {"type": "b", "children": [{"type": "t", "text": "Functional characterization of testis-brain RNA-binding protein, TB-RBP/Translin, in translational regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Reprod Dev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1262/jrd.2020-120"}], "href": "https://doi.org/10.1262/jrd.2020-120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33268667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33268667"}]}]}]}