TNFAIP1 Gene

HGNC Family	BTB (POZ) domain containing (BTBD)
Name	tumor necrosis factor, alpha-induced protein 1 (endothelial)
Description	This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTumor necrosis factor α‐induced protein 1 (TNFAIP1) is a multifunctional protein originally identified as an early response gene to inflammatory cytokines. Several studies report that TNFAIP1 expression is elevated in the brains of Alzheimer’s disease patients, suggesting a role in neuronal stress and degenerative processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Its basal transcription is regulated by key transcription factors such as Sp1, and post‐translational modifications – for instance, phosphorylation by CK2 – appear to modulate its nuclear localization and interaction with proteins involved in DNA synthesis and repair, including proliferating cell nuclear antigen (PCNA)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn diverse cancer contexts, TNFAIP1 displays context‐dependent functionality. In some osteosarcoma studies, its overexpression correlates with distant metastasis, where knockdown inhibits cell proliferation and invasion by dampening NF‐κB signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Conversely, in hepatocellular and pancreatic carcinoma models, increased TNFAIP1 expression—often achieved through downregulation of specific microRNAs (e.g., miR‑15a and miR‑181a)—acts in a tumor‐suppressive fashion by promoting apoptosis and reducing cell migration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": " Further complexity is added by its role in lung cancer, where TNFAIP1 is implicated both in modulating cell migration and in mediating resistance to therapeutics such as paclitaxel—by competing for binding to β‑tubulin—and where noncoding RNAs (e.g., circ0001320 via miR‑558 sequestration) help control its levels to impact tumor cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, protein–protein interactions further regulate TNFAIP1’s functions; for example, its binding to KCTD10 promotes ubiquitin‐mediated degradation and concurrently suppresses NF‑κB and AP‑1 transcriptional activities."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In addition, regulatory mechanisms involving the CRL3–BTBD9 ubiquitin ligase complex have been shown to control TNFAIP1 turnover, thereby influencing lung cancer cell migratory behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christopher D Link, Andrew Taft, Vadim Kapulkin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0197-4580(02)00224-5"}], "href": "https://doi.org/10.1016/s0197-4580(02"}, {"type": "t", "text": "00224-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12600716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12600716"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mingjun Liu, Zhenhua Sun, Aidong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional characterization of the promoter region of human TNFAIP1 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-009-9588-1"}], "href": "https://doi.org/10.1007/s11033-009-9588-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19593659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19593659"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Liping Yang, Ning Liu, Xiang Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-009-9863-1"}], "href": "https://doi.org/10.1007/s11033-009-9863-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19851886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19851886"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Cheng-Lin Zhang, Ce Wang, Wang-Jun Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of TNFAIP1 inhibits growth and induces apoptosis in osteosarcoma cells through inhibition of the nuclear factor-κB pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2014.3291"}], "href": "https://doi.org/10.3892/or.2014.3291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24969828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24969828"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Peng Zhang, Zhiyong Guo, Ronglin Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between microRNA-181a and TNFAIP1 regulates pancreatic cancer proliferation and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3704-8"}], "href": "https://doi.org/10.1007/s13277-015-3704-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26152285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26152285"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xu Tian, Jian Zhang, Liang Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-15a inhibits proliferation, migration and invasion by targeting TNFAIP1 in human osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26261520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26261520"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ye Xiao, Shulan Huang, Feng Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis factor α-induced protein 1 as a novel tumor suppressor through selective downregulation of CSNK2B blocks nuclear factor-κB activation in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2019.102603"}], "href": "https://doi.org/10.1016/j.ebiom.2019.102603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31901862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31901862"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Y Zhu, Z Yao, Z Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of tumor necrosis factor alpha-induced protein 1 in paclitaxel resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.299"}], "href": "https://doi.org/10.1038/onc.2013.299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23912453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23912453"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yong Mao, Jia-Xi He, Mei Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-020-00453-4"}], "href": "https://doi.org/10.1007/s13577-020-00453-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33128699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33128699"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiang Hu, Feng Yan, Fangmei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-012-1858-7"}], "href": "https://doi.org/10.1007/s11033-012-1858-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22810651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22810651"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lihui Li, Wenjuan Zhang, Yue Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The CRL3"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "BTBD9"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Signal Transduct Target Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41392-020-0140-z"}], "href": "https://doi.org/10.1038/s41392-020-0140-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32327643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32327643"}]}]}]}
Synonyms	HBACURD2, EDP1, BTBD34
Proteins	BACD2_HUMAN
NCBI Gene ID	7126
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TNFAIP1 has 6,809 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 121 datasets.

Click the + buttons to view associations for TNFAIP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TNFAIP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNFAIP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TNFAIP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TNFAIP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TNFAIP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNFAIP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TNFAIP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNFAIP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNFAIP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TNFAIP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TNFAIP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TNFAIP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TNFAIP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNFAIP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TNFAIP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TNFAIP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TNFAIP1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TNFAIP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TNFAIP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TNFAIP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TNFAIP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TNFAIP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TNFAIP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TNFAIP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TNFAIP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TNFAIP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TNFAIP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TNFAIP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TNFAIP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TNFAIP1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TNFAIP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TNFAIP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for TNFAIP1 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TNFAIP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TNFAIP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TNFAIP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TNFAIP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TNFAIP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TNFAIP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNFAIP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TNFAIP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.