TNFRSF1A Gene

HGNC Family	CD molecules (CD), Tumor necrosis factor receptor superfamily (TNFRSF)
Name	tumor necrosis factor receptor superfamily, member 1A
Description	This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTNFRSF1A, the gene encoding tumor necrosis factor receptor 1 (TNFR1), plays a pivotal role in mediating the cellular response to TNF‐α. Upon ligand binding, TNFRSF1A initiates a dual signaling cascade: at the plasma membrane, it forms an initial complex that recruits adaptors (e.g. TRADD and RIP1) to activate canonical NF‐κB signaling and promote prosurvival gene expression, whereas failure to properly stimulate NF‐κB leads to formation of a secondary cytoplasmic complex that engages FADD and caspase‐8, triggering apoptosis. In addition, the receptor recruits kinases such as TAK1—with contributions from regulators like PAK4—to ensure robust activation of intracellular pathways that determine cell fate."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTNFRSF1A activity is tightly modulated by both genetic and molecular mechanisms that impact receptor availability and downstream signaling. Specific polymorphisms in TNFRSF1A can lead to the aberrant expression of soluble receptor variants that sequester TNF‐α, as observed in multiple sclerosis susceptibility. In a different regulatory mechanism, viral proteins (for example, the HPV E6 oncoprotein) directly bind the receptor’s death domain, thereby disrupting the assembly of the death–inducing signaling complex and blunting apoptotic responses. Moreover, proteolytic cleavage driven by ARTS‐1 controls TNFRSF1A shedding from the cell surface, modulating the intensity and duration of TNF–α signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical signaling functions, dysregulated TNFRSF1A activity is implicated in a spectrum of pathological conditions. For instance, in autoinflammatory disorders such as tumor necrosis factor receptor–associated periodic syndrome (TRAPS), mutant TNFRSF1A accumulates intracellularly and hyperactivates MAPK cascades. Aberrant signaling via this receptor also contributes to tissue inflammation and damage in diverse settings – from promoting keratinocyte apoptosis and skin inflammation to driving lymphangiogenesis and enhancing metastatic potential in cancer. In addition, TNFRSF1A signaling underlies the activation of hepatic stellate cells in fibrogenesis, modulates cytokine and chemokine production in airway smooth muscle cells, and participates in immune cell cross‐talk that amplifies inflammation in rheumatoid arthritis. Elevated levels of circulating soluble TNFRSF1A are associated with severe systemic inflammatory responses such as those seen in sepsis, and altered receptor expression and binding affinity have been documented in neurodegenerative disorders like Alzheimer’s disease as well as in kidney injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Olivier Micheau, Jürg Tschopp "}, {"type": "b", "children": [{"type": "t", "text": "Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(03)00521-x"}], "href": "https://doi.org/10.1016/s0092-8674(03"}, {"type": "t", "text": "00521-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12887920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12887920"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaofan Li, Audrey Minden "}, {"type": "b", "children": [{"type": "t", "text": "PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M506884200"}], "href": "https://doi.org/10.1074/jbc.M506884200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16227624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16227624"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marzenna Blonska, Prashant B Shambharkar, Masayuki Kobayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M507807200"}], "href": "https://doi.org/10.1074/jbc.M507807200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16260783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16260783"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alice Borghi, Lynn Verstrepen, Rudi Beyaert "}, {"type": "b", "children": [{"type": "t", "text": "TRAF2 multitasking in TNF receptor-induced signaling to NF-κB, MAP kinases and cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcp.2016.03.009"}], "href": "https://doi.org/10.1016/j.bcp.2016.03.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26993379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26993379"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maria Filippova, Helen Song, Jodi L Connolly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M200113200"}], "href": "https://doi.org/10.1074/jbc.M200113200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11934887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11934887"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xinle Cui, Farshid N Rouhani, Feras Hawari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M300456200"}], "href": "https://doi.org/10.1074/jbc.M300456200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12748171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12748171"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Adam P Gregory, Calliope A Dendrou, Kathrine E Attfield, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature11307"}], "href": "https://doi.org/10.1038/nature11307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22801493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22801493"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Y Amrani, A J Ammit, R A Panettieri "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-alpha-induced interleukin-6 and RANTES in human airway smooth muscle cells: role of p38 and p42/44 mitogen-activated protein kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2001)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11562425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11562425"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "A C Gordon, A L Lagan, E Aganna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Immun (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.gene.6364136"}], "href": "https://doi.org/10.1038/sj.gene.6364136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15526005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15526005"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rafia S Al-Lamki, Jun Wang, Peter Vandenabeele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.05-3841com"}], "href": "https://doi.org/10.1096/fj.05-3841com"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16195372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16195372"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Manuela Rossol, Undine Meusch, Matthias Pierer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.179.6.4239"}], "href": "https://doi.org/10.4049/jimmunol.179.6.4239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17785864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17785864"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xin Cheng, Libang Yang, Ping He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-2010-1253"}], "href": "https://doi.org/10.3233/JAD-2010-1253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20110607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20110607"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Anna Simon, Heiyoung Park, Ravikanth Maddipati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0914118107"}], "href": "https://doi.org/10.1073/pnas.0914118107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20457915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20457915"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Núria Tarrats, Anna Moles, Albert Morales, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.24388"}], "href": "https://doi.org/10.1002/hep.24388"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21523796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21523796"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "H Oshima, T Ishikawa, G J Yoshida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.356"}], "href": "https://doi.org/10.1038/onc.2013.356"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23975421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23975421"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hong Ji, Renhai Cao, Yunlong Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms5944"}], "href": "https://doi.org/10.1038/ncomms5944"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25229256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25229256"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Snehlata Kumari, Younes Redouane, Jaime Lopez-Mosqueda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.03422"}], "href": "https://doi.org/10.7554/eLife.03422"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25443631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25443631"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yun Dong, Roman Fischer, Petrus J W Naudé, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1605195113"}], "href": "https://doi.org/10.1073/pnas.1605195113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27791020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27791020"}]}]}]}
Synonyms	FPF, TNFR55, MS5, TNFR1-D2, TNFAR, TNFR1, TNFR60, TNF-R, TNF-R-I, CD120A, TNF-R55, P55-R
Proteins	TNR1A_HUMAN
NCBI Gene ID	7132
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TNFRSF1A has 15,110 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 149 datasets.

Click the + buttons to view associations for TNFRSF1A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TNFRSF1A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNFRSF1A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNFRSF1A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TNFRSF1A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TNFRSF1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TNFRSF1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNFRSF1A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving TNFRSF1A protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TNFRSF1A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNFRSF1A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNFRSF1A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TNFRSF1A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TNFRSF1A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TNFRSF1A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with TNFRSF1A gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TNFRSF1A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TNFRSF1A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNFRSF1A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TNFRSF1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TNFRSF1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TNFRSF1A gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TNFRSF1A gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TNFRSF1A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TNFRSF1A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TNFRSF1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TNFRSF1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TNFRSF1A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TNFRSF1A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TNFRSF1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TNFRSF1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TNFRSF1A protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TNFRSF1A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TNFRSF1A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TNFRSF1A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TNFRSF1A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TNFRSF1A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TNFRSF1A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TNFRSF1A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for TNFRSF1A protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving TNFRSF1A gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TNFRSF1A gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.