TNIP1 Gene

Name	TNFAIP3 interacting protein 1
Description	This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nGenetic studies have repeatedly implicated TNIP1 in a spectrum of immune‐mediated inflammatory diseases. Genome‐wide association studies in psoriasis, systemic lupus erythematosus (SLE), and systemic sclerosis have identified TNIP1 variants as risk factors and demonstrated its altered expression in patient tissues—for example, reduced TNIP1 expression in skin lesions and dermal fibroblasts correlates with increased inflammatory signaling. Such genetic associations underscore a role for TNIP1 in maintaining immune homeostasis by potentially limiting pro‐inflammatory pathways in diverse conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, TNIP1 (also known as ABIN‐1) functions as an important negative regulator of nuclear factor‐kappaB (NF‑κB) signaling. Acting as an ubiquitin‐binding adaptor via its conserved UBAN domain, TNIP1 bridges interactions with key signaling proteins such as NEMO and A20 to inhibit the phosphorylation and degradation of inhibitory proteins, thereby tempering NF‑κB activation in response to stimuli including tumor necrosis factor‐α and toll-like receptor ligands. Functional studies in cellular and animal models further demonstrate that impairment of TNIP1’s ubiquitin binding or its interaction with A20 leads to enhanced NF‑κB–dependent cytokine production and autoimmunity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical NF‑κB inhibitory functions, TNIP1 also exerts modulatory effects on other signaling pathways. It acts as an atypical nuclear receptor corepressor—dampening retinoic acid receptor signaling—and influences T cell receptor–mediated responses through interactions with the CBM complex. In addition, TNIP1 deficiency has been linked to enhanced necroptosis in cancer cells, emphasizing its role in controlling cell death pathways and highlighting potential therapeutic avenues for inflammatory and neoplastic diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rajan P Nair, Kristina Callis Duffin, Cynthia Helms, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.311"}], "href": "https://doi.org/10.1038/ng.311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19169254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19169254"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "J T Elder "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Immun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/gene.2009.11"}], "href": "https://doi.org/10.1038/gene.2009.11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19262574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19262574"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Vesela Gateva, Johanna K Sandling, Geoff Hom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.468"}], "href": "https://doi.org/10.1038/ng.468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19838195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19838195"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "C-F He, Y-S Liu, Y-L Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lupus (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0961203310367918"}], "href": "https://doi.org/10.1177/0961203310367918"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20516000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20516000"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lara Bossini-Castillo, Jose Ezequiel Martin, Jasper Broen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/annrheumdis-2012-201888"}], "href": "https://doi.org/10.1136/annrheumdis-2012-201888"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22896740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22896740"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "X-L Li, H Yu, G-S Wu "}, {"type": "b", "children": [{"type": "t", "text": "Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Immunogenet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/iji.12150"}], "href": "https://doi.org/10.1111/iji.12150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25264125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25264125"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Claudio Mauro, Francesco Pacifico, Alfonso Lavorgna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M601502200"}], "href": "https://doi.org/10.1074/jbc.M601502200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16684768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16684768"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "S Wagner, I Carpentier, V Rogov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1211042"}], "href": "https://doi.org/10.1038/sj.onc.1211042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18212736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18212736"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lynn Verstrepen, Isabelle Carpentier, Kelly Verhelst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcp.2009.02.009"}], "href": "https://doi.org/10.1016/j.bcp.2009.02.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19464428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19464428"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Shai Cohen, Aaron Ciechanover, Yelena Kravtsova-Ivantsiv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.08.074"}], "href": "https://doi.org/10.1016/j.bbrc.2009.08.074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19695220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19695220"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Aya Kawasaki, Satoshi Ito, Hiroshi Furukawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/ar3134"}], "href": "https://doi.org/10.1186/ar3134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20849588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20849588"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sambit K Nanda, Ram K C Venigalla, Alban Ordureau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polyubiquitin binding to ABIN1 is required to prevent autoimmunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20102177"}], "href": "https://doi.org/10.1084/jem.20102177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21606507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21606507"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Linlin Gao, Helen Coope, Susan Grant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.283762"}], "href": "https://doi.org/10.1074/jbc.M111.283762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21885437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21885437"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hongli Yin, Ozge Karayel, Ying-Yin Chao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-022-04154-z"}], "href": "https://doi.org/10.1007/s00018-022-04154-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35099607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35099607"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Igor Gurevich, Brian J Aneskievich "}, {"type": "b", "children": [{"type": "t", "text": "Liganded RARalpha and RARgamma interact with but are repressed by TNIP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.08.159"}], "href": "https://doi.org/10.1016/j.bbrc.2009.08.159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19732752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19732752"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Anthony M Flores, Igor Gurevich, Carmen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNIP1 is a corepressor of agonist-bound PPARs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2011.08.014"}], "href": "https://doi.org/10.1016/j.abb.2011.08.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21967852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21967852"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Lilla Erdei, Beáta Szilvia Bolla, Renáta Bozó, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNIP1 Regulates "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Cutibacterium acnes"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-Induced Innate Immune Functions in Epidermal Keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2018.02155"}], "href": "https://doi.org/10.3389/fimmu.2018.02155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30319618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30319618"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Rambon Shamilov, Brian J Aneskievich "}, {"type": "b", "children": [{"type": "t", "text": "TNIP1 in Autoimmune Diseases: Regulation of Toll-like Receptor Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2018/3491269"}], "href": "https://doi.org/10.1155/2018/3491269"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30402506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30402506"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Dawn J Caster, David W Powell "}, {"type": "b", "children": [{"type": "t", "text": "Utilization of Biomarkers in Lupus Nephritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Chronic Kidney Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.ackd.2019.09.001"}], "href": "https://doi.org/10.1053/j.ackd.2019.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31733719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31733719"}]}]}]}
Synonyms	NAF1, ABIN-1, VAN, NIP40-1
Proteins	TNIP1_HUMAN
NCBI Gene ID	10318
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TNIP1 has 12,203 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 124 datasets.

Click the + buttons to view associations for TNIP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TNIP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TNIP1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNIP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TNIP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TNIP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TNIP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNIP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TNIP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNIP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNIP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TNIP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TNIP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TNIP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TNIP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TNIP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNIP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TNIP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TNIP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TNIP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TNIP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TNIP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TNIP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TNIP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TNIP1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TNIP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TNIP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TNIP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TNIP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TNIP1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TNIP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TNIP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TNIP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TNIP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TNIP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TNIP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TNIP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TNIP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNIP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TNIP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TNIP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with TNIP1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.