| Name | TNNI3 interacting kinase |
| Description | This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTNNI3K is a novel, cardiac‐restricted protein kinase that was originally identified as a distant relative of integrin‐linked kinase and is expressed almost exclusively in the heart. It localizes predominantly to the nucleus and to components of the sarcomere such as the Z disc, and it directly interacts with cardiac troponin I. Structural studies indicate that TNNI3K possesses both tyrosine and serine/threonine kinase activities, and its modular organization—including N‐terminal ankyrin repeats and a C‐terminal regulatory domain—suggests that intramolecular regulation (such as autophosphorylation and dimer/oligomer formation) is critical for its function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its basal expression, TNNI3K plays a pivotal role in modulating cardiac cell fate and functional performance. Overexpression studies in experimental models have demonstrated that elevated TNNI3K activity promotes cardiomyocyte differentiation (including embryonic stem cell-derived cardiomyogenesis), accelerates cardiac remodeling and hypertrophy, and improves contractile function. In models of ischemic injury, increased TNNI3K activity has been linked to enhanced beating frequency and contractile strength as well as protection against apoptosis, indicating its involvement in adaptive as well as maladaptive responses of the myocardium."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies have implicated TNNI3K mutations in a range of cardiac electrical and myopathic diseases. Missense, splice site, and nonsense variants in its highly conserved kinase domain have been linked to familial syndromes presenting with dilated cardiomyopathy, conduction system disease, atrial tachyarrhythmias, and even congenital junctional ectopic tachycardia. Several studies have demonstrated that these pathogenic variants often lead to a reduction or alteration of kinase activity—through mechanisms such as protein aggregation, disrupted dimerization, or nonsense-mediated decay—thereby contributing to altered cardiac conduction and structural remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent insights also extend the functional repertoire of TNNI3K, implicating it in the regulation of cardiac regenerative capacity—by influencing the frequency of mononuclear diploid cardiomyocytes—and positioning it as a promising therapeutic target. Structural and small molecule studies have begun to outline the structure–activity relationships of TNNI3K inhibitors, paving the way for potential clinical interventions aimed at mitigating ischemia–reperfusion injury and adverse remodeling while minimizing off-target effects due to its cardiac specificity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yong Zhao, Xian-Min Meng, Ying-Jie Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Med (Berl) (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00109-003-0427-x"}], "href": "https://doi.org/10.1007/s00109-003-0427-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12721663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12721663"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Y Feng, H Q Cao, Z Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the dual specificity and the functional domains of the cardiac-specific protein kinase TNNI3K."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gen Physiol Biophys (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17660584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17660584"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Feng, Dong-Qing Liu, Zhen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AOP-1 interacts with cardiac-specific protein kinase TNNI3K and down-regulates its kinase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (Mosc) (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/s0006297907110053"}], "href": "https://doi.org/10.1134/s0006297907110053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18205602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18205602"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hao Tang, Kunhong Xiao, Lan Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2012.10.004"}], "href": "https://doi.org/10.1016/j.yjmcc.2012.10.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23085512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23085512"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhong-Fang Lai, Yu-Zhen Chen, Li-Ping Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.00252.2008"}], "href": "https://doi.org/10.1152/ajpheart.00252.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18552163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18552163"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhong-Fang Lai "}, {"type": "b", "children": [{"type": "t", "text": "TNNI3K could be a novel molecular target for the treatment of cardiac diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Recent Pat Cardiovasc Drug Discov (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/157489009789152285"}], "href": "https://doi.org/10.2174/157489009789152285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19925440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19925440"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lin Wang, Hui Wang, Jue Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adenovirus-mediated overexpression of cardiac troponin I-interacting kinase promotes cardiomyocyte hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Pharmacol Physiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1440-1681.2011.05499.x"}], "href": "https://doi.org/10.1111/j.1440-1681.2011.05499.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21314842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21314842"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hind Lal, Firdos Ahmad, Shan Parikh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Troponin I-interacting protein kinase: a novel cardiac-specific kinase, emerging as a molecular target for the treatment of cardiac disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1253/circj.cj-14-0543"}], "href": "https://doi.org/10.1253/circj.cj-14-0543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24899531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24899531"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yin Wang, Shi-Qiang Wang, Li-Peng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000456400"}], "href": "https://doi.org/10.1159/000456400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28135716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28135716"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jeanne L Theis, Michael T Zimmermann, Brandon T Larsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddu297"}], "href": "https://doi.org/10.1093/hmg/ddu297"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24925317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24925317"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Amit Kumar, Bindu Rani, Rajni Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ACE2, CALM3 and TNNI3K polymorphisms as potential disease modifiers in hypertrophic and dilated cardiomyopathies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-017-3123-9"}], "href": "https://doi.org/10.1007/s11010-017-3123-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28744816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28744816"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Liang-Liang Fan, Hao Huang, Jie-Yuan Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole exome sequencing identifies a novel mutation (c.333 + 2T > C) of TNNI3K in a Chinese family with dilated cardiomyopathy and cardiac conduction disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.01.055"}], "href": "https://doi.org/10.1016/j.gene.2018.01.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29355681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29355681"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zahia Touat-Hamici, Malorie Blancard, Ruifang Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-84373-9"}], "href": "https://doi.org/10.1038/s41598-021-84373-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33664309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33664309"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shafaq Ramzan, Stephanie Tennstedt, Muhammad Tariq, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Missense Mutation in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TNNI3K"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Causes Recessively Inherited Cardiac Conduction Disease in a Consanguineous Pakistani Family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes12081282"}], "href": "https://doi.org/10.3390/genes12081282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34440456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34440456"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Caroline Pham, Tamara T Koopmann, Jeffrey M Vinocur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced kinase function in two ultra-rare TNNI3K variants in families with congenital junctional ectopic tachycardia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.14504"}], "href": "https://doi.org/10.1111/cge.14504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38424693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38424693"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Peiheng Gan, Michaela Patterson, Alexa Velasquez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1008354"}], "href": "https://doi.org/10.1371/journal.pgen.1008354"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31589606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31589606"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Christopher R M Asquith, Tuomo Laitinen, Carrow I Wells, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Molecules (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/molecules25071697"}], "href": "https://doi.org/10.3390/molecules25071697"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32272798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32272798"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jiang Liu, Da Liu, Muzheng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a nonsense mutation in TNNI3K associated with cardiac conduction disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23418"}], "href": "https://doi.org/10.1002/jcla.23418"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32529721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32529721"}]}]}]}
|
| Synonyms | CCDD, CARK |
| Proteins | TNI3K_HUMAN |
| NCBI Gene ID | 51086 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
TNNI3K has 2,502 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 75 datasets.
Click the + buttons to view associations for TNNI3K from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of TNNI3K gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of TNNI3K gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of TNNI3K gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of TNNI3K gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of TNNI3K gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TNNI3K gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TNNI3K gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of TNNI3K gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Mutation Profiles | cell lines with TNNI3K gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with TNNI3K protein from the CCLE Cell Line Proteomics dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNNI3K gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of TNNI3K gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of TNNI3K gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TNNI3K gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of TNNI3K gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with TNNI3K gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with TNNI3K gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with TNNI3K gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of TNNI3K protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by TNNI3K gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving TNNI3K gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with TNNI3K gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TNNI3K gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with TNNI3K gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with TNNI3K gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TNNI3K gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNNI3K gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of TNNI3K gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing TNNI3K from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with TNNI3K gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of TNNI3K gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with TNNI3K gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing TNNI3K from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of TNNI3K gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TNNI3K gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of TNNI3K gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TNNI3K gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of TNNI3K gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of TNNI3K gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving TNNI3K gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing TNNI3K protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of TNNI3K gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TNNI3K gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TNNI3K gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of TNNI3K gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with TNNI3K gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with TNNI3K gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for TNNI3K protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of TNNI3K gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of TNNI3K gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TNNI3K gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for TNNI3K from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with TNNI3K gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of TNNI3K gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of TNNI3K gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with TNNI3K gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of TNNI3K gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS KinomeScan Kinase Inhibitor Targets | small molecules inhibiting TNNI3K kinase from the KinomeScan Kinase Inhibitor Targets dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of TNNI3K gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain TNNI3K protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by TNNI3K gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of TNNI3K gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of TNNI3K gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of TNNI3K gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| OMIM Gene-Disease Associations | phenotypes associated with TNNI3K gene from the curated OMIM Gene-Disease Associations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for TNNI3K from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of TNNI3K gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving TNNI3K protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving TNNI3K protein from the Wikipathways PFOCR 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of TNNI3K gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TNNI3K gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TNNI3K gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of TNNI3K gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of TNNI3K gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of TNNI3K gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
