{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTNRC6B is a core component of the miRNA‐mediated gene silencing machinery. As a member of the GW182 protein family, TNRC6B contains an N‐terminal region rich in GW repeats that binds Argonaute proteins and a C‐terminal domain that recruits additional factors to repress translation and promote mRNA degradation—including deadenylation. In conjunction with its paralogs TNRC6A and TNRC6C, TNRC6B thus serves as a scaffolding protein that bridges Argonaute–miRNA complexes to effector proteins, ensuring effective post‐transcriptional control."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in RNA interference, genetic and epigenetic studies have linked TNRC6B to multiple disease states. Genome‐wide association studies have implicated genetic variants within the TNRC6B locus in both aggressive and nonaggressive prostate cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " Similarly, common variants and haplotypes in TNRC6B have been associated with risk and specific clinical features—such as nodule size—in uterine fibroids, with findings replicated in diverse populations, including European American and Chinese cohorts as well as studies in Arab women."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": " Moreover, studies in head and neck squamous cell carcinoma have uncovered ceRNA networks in which TNRC6B acts downstream of long noncoding RNAs to regulate cellular proliferation and stemness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, TNRC6B influences other biological processes. In hepatitis C virus replication, TNRC6B (in functional redundancy with its paralog TNRC6C) modulates miR‐122/Argonaute2 complex assembly on the viral RNA genome, thereby fine‐tuning viral RNA synthesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Rare heterozygous truncating variants in TNRC6B have also been reported in patients with global developmental delay, speech and behavioral abnormalities, and features within the autism spectrum."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Daniela Lazzaretti, Isabelle Tournier, Elisa Izaurralde "}, {"type": "b", "children": [{"type": "t", "text": "The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.1606309"}], "href": "https://doi.org/10.1261/rna.1606309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19383768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19383768"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhongtian Liu, Samantha T Johnson, Zhiying Zhang, et al. 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