TNS1 Gene

HGNC Family	SH2 domain containing, Protein phosphatase 1 regulatory subunits (PPP1R), C2 domain containing, Phosphatases
Name	tensin 1
Description	The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTensin1, the protein product of the TNS1 gene, is a multidomain scaffold that physically links the cytoplasmic tails of integrins to the actin cytoskeleton at focal and fibrillar adhesions. Through its multiple binding interfaces, tensin1 orchestrates cell polarization, migration, and adhesion by interacting selectively with proteins such as protein phosphatase-1α, focal adhesion kinase, and regulators of Rho GTPases. Aberrant tensin1 expression or post‐translational modification has been implicated in developmental anomalies and cancers, supporting its role in coordinating extracellular matrix (ECM) signaling and cell–matrix interactions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic association studies have identified common variants in TNS1 that correlate with measures of pulmonary function and susceptibility to chronic obstructive pulmonary disease. In lung tissue, tensin1 is robustly expressed in airway smooth muscle cells and is inducible by transforming growth factor–β1, which enhances its localization to fibrillar adhesions essential for extracellular fibronectin and collagen matrix assembly. Furthermore, altered tyrosine phosphorylation patterns of tensin1 have been linked to lung adenocarcinoma aggressiveness, while its increased expression in COPD airways may contribute to enhanced contractile protein expression and airway remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond the lung, tensin1 is emerging as a critical mediator in tumor progression and tissue remodeling across diverse organ systems. In breast cancer, tensin1 is a direct target of regulatory non‐coding RNAs—both microRNAs and long non‐coding RNAs—that alter its expression, disrupt focal adhesion dynamics, and consequently promote cell invasion and metastasis. In parallel, tensin1 regulates ECM production and adhesion complex formation in renal and bladder tissues, with its loss leading to disrupted lumenogenesis in kidney epithelial cells and contributing to cyst formation. Its function as a modifier gene has even been demonstrated in cystic fibrosis, where certain TNS1 variants correlate with lower body mass index, and in prostate cancer, where tensin1 transcriptional activation via hepatic leukemia factor can trigger the p53 tumor suppressor pathway. Collectively, these studies underscore the versatile role of tensin1 in modulating cell–matrix interactions, cytoskeletal organization, and signal transduction that underlie both normal physiology and disease progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "T H Beaty, J B Hetmanski, M D Fallin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-006-0235-9"}], "href": "https://doi.org/10.1007/s00439-006-0235-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16953426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16953426"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Masumi Eto, Jason Kirkbride, Elizabeth Elliott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M700944200"}], "href": "https://doi.org/10.1074/jbc.M700944200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17435217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17435217"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gaëlle Saintigny, François-Xavier Bernard, Franck Juchaux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Dermatol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0625.2008.00707.x"}], "href": "https://doi.org/10.1111/j.1600-0625.2008.00707.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18537817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18537817"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Danuta Martuszewska, Börje Ljungberg, Martin Johansson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0004350"}], "href": "https://doi.org/10.1371/journal.pone.0004350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19194507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19194507"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Li-juan Huang, Bo DU, Hui Song "}, {"type": "b", "children": [{"type": "t", "text": "[Tensin expression in mesangial cells of human kidney]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19664390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19664390"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Emily H Hall, Abbi E Daugherty, Colin K Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.059592"}], "href": "https://doi.org/10.1074/jbc.M109.059592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19826001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19826001"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Emily H Hall, Jeremy L Balsbaugh, Kristie L Rose, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M110.003665"}], "href": "https://doi.org/10.1074/mcp.M110.003665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20798394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20798394"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Emmanouela Repapi, Ian Sayers, Louise V Wain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies five loci associated with lung function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.501"}], "href": "https://doi.org/10.1038/ng.501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20010834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20010834"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "María Soler Artigas, Louise V Wain, Emmanouela Repapi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Crit Care Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1164/rccm.201102-0192OC"}], "href": "https://doi.org/10.1164/rccm.201102-0192OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21965014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21965014"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Akiko Okayama, Yohei Miyagi, Fumihiro Oshita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Tyrosine-Phosphorylated Proteins Upregulated during Epithelial-Mesenchymal Transition Induced with TGF-β."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.5b00082"}], "href": "https://doi.org/10.1021/acs.jproteome.5b00082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26216473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26216473"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Panayiota Stylianou, Katherine Clark, Bibek Gooptu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tensin1 expression and function in chronic obstructive pulmonary disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-55405-2"}], "href": "https://doi.org/10.1038/s41598-019-55405-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31831813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31831813"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jinjin Duan, Li Wang, Liqun Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-152/TNS1 axis inhibits non-small cell lung cancer progression through Akt/mTOR/RhoA pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20201539"}], "href": "https://doi.org/10.1042/BSR20201539"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33269380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33269380"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yun Zhan, Xiaoshuan Liang, Lin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-548j functions as a metastasis promoter in human breast cancer by targeting Tensin1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molonc.2016.02.002"}], "href": "https://doi.org/10.1016/j.molonc.2016.02.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26949125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26949125"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ksenija Bernau, Elizabeth E Torr, Michael D Evans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2016-0104OC"}], "href": "https://doi.org/10.1165/rcmb.2016-0104OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28005397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28005397"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Gregory J Goreczny, Ian J Forsythe, Christopher E Turner "}, {"type": "b", "children": [{"type": "t", "text": "Hic-5 regulates fibrillar adhesion formation to control tumor extracellular matrix remodeling through interaction with tensin1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-017-0074-2"}], "href": "https://doi.org/10.1038/s41388-017-0074-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29348458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29348458"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Zong-Ye Wu, Chun-Lung Chiu, Ethan Lo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-2119-7"}], "href": "https://doi.org/10.1038/s41419-019-2119-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31740667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31740667"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Congyi Tang, Yi Cai, Huichuan Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.104162"}], "href": "https://doi.org/10.18632/aging.104162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33231563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33231563"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Kung-Chi Chang, Sarah D Diermeier, Allen T Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-20207-y"}], "href": "https://doi.org/10.1038/s41467-020-20207-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33353933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33353933"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Nathan I Walton, Xijun Zhang, Anthony R Soltis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tensin 1 (TNS1) is a modifier gene for low body mass index (BMI) in homozygous [F508del]CFTR patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14814/phy2.14886"}], "href": "https://doi.org/10.14814/phy2.14886"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34086412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34086412"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hao Zhou, Fang Wang "}, {"type": "b", "children": [{"type": "t", "text": "Tensin 1 regulated by hepatic leukemia factor represses the progression of prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mutagenesis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/mutage/gead027"}], "href": "https://doi.org/10.1093/mutage/gead027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37712764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37712764"}]}]}]}
Synonyms	MSTP122, MST122, MXRA6, MSTP091, PPP1R155, TNS, MST127, MST091, MSTP127
Proteins	TENS1_HUMAN
NCBI Gene ID	7145
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TNS1 has 10,125 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.

Click the + buttons to view associations for TNS1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TNS1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TNS1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNS1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNS1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TNS1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TNS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TNS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TNS1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving TNS1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TNS1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNS1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TNS1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TNS1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TNS1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TNS1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TNS1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNS1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TNS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TNS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TNS1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TNS1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TNS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TNS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TNS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TNS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TNS1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TNS1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TNS1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TNS1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TNS1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TNS1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TNS1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TNS1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TNS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TNS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TNS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TNS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TNS1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TNS1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TNS1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TNS1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.