TOP3A Gene

HGNC Family	Zinc fingers
Name	topoisomerase (DNA) III alpha
Description	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTOP3A, a type IA DNA topoisomerase, plays a central role in nuclear genome maintenance by acting as an essential component of the BLM dissolvasome complex. In association with the BLM helicase and partners such as BLAP75 and RMI1/2, TOP3A promotes the dissolution of complex DNA structures—including double Holliday junctions—generated during homologous recombination. This coordinated action prevents crossover formation during DNA repair and facilitates decatenation of single‐stranded intermediates, thereby preserving chromosome integrity and reducing cancer predisposition."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its functions in the nucleus, TOP3A is also critical for mitochondrial DNA metabolism. A distinct isoform of TOP3A is targeted to mitochondria via an N‐terminal mitochondrial import signal, where it contributes to the proper termination, decatenation, and segregation of mitochondrial DNA replication intermediates. This mitochondrial activity ensures efficient gene expression and energy production, and defects in TOP3A’s mitochondrial role have been linked to mitochondrial diseases characterized by compromised ATP generation and mtDNA deletions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, TOP3A has emerged as a pivotal factor in telomere maintenance and the modulation of genome stability in both normal and cancerous cells. In settings where telomere elongation is achieved by alternative recombination‐based mechanisms (ALT), TOP3A associates with telomeric proteins to resolve complex DNA structures at chromosomal ends, thereby preventing telomere dysfunction. Variants in TOP3A have been implicated in Bloom syndrome–like disorders and are associated with heightened cancer risk as they disrupt normal DNA transactions across nuclear and mitochondrial compartments. These studies underscore the multifaceted contributions of TOP3A to homologous recombination, telomere recombination, and overall genome integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "21"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Steven Raynard, Wendy Bussen, Patrick Sung "}, {"type": "b", "children": [{"type": "t", "text": "A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C600051200"}], "href": "https://doi.org/10.1074/jbc.C600051200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16595695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16595695"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wendy Bussen, Steven Raynard, Valeria Busygina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M706116200"}], "href": "https://doi.org/10.1074/jbc.M706116200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17728255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17728255"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Steven Raynard, Weixing Zhao, Wendy Bussen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional role of BLAP75 in BLM-topoisomerase IIIalpha-dependent holliday junction processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M802127200"}], "href": "https://doi.org/10.1074/jbc.M802127200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18390547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18390547"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Leonard Wu, Ian D Hickson "}, {"type": "b", "children": [{"type": "t", "text": "The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkf611"}], "href": "https://doi.org/10.1093/nar/gkf611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12433984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12433984"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jay Yang, Csanad Z Bachrati, Jiongwen Ou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.123216"}], "href": "https://doi.org/10.1074/jbc.M110.123216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20445207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20445207"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "James M Daley, Tamara Chiba, Xiaoyu Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multifaceted role of the Topo IIIα-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gku803"}], "href": "https://doi.org/10.1093/nar/gku803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25200081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25200081"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Gábor M Harami, János Pálinkás, Yeonee Seol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-28208-9"}], "href": "https://doi.org/10.1038/s41467-022-28208-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35115525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35115525"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Michael M Soniat, Giaochau Nguyen, Hung-Che Kuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The MRN complex and topoisomerase IIIa-RMI1/2 synchronize DNA resection motor proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2022.102802"}], "href": "https://doi.org/10.1016/j.jbc.2022.102802"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36529288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36529288"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yong Wang, Yi Lisa Lyu, James C Wang "}, {"type": "b", "children": [{"type": "t", "text": "Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.192449499"}], "href": "https://doi.org/10.1073/pnas.192449499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12209014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12209014"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Thomas J Nicholls, Cristina A Nadalutti, Elisa Motori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2017.11.033"}], "href": "https://doi.org/10.1016/j.molcel.2017.11.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29290614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29290614"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Thomas Aschacher, Brigitte Wolf, Olivia Aschacher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long interspersed element-1 ribonucleoprotein particles protect telomeric ends in alternative lengthening of telomeres dependent cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neo.2019.11.002"}], "href": "https://doi.org/10.1016/j.neo.2019.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31846834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31846834"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Direnis Erdinc, Alejandro Rodríguez-Luis, Mahmoud R Fassad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.202216775"}], "href": "https://doi.org/10.15252/emmm.202216775"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37013609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37013609"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Wenjun Jiang, Nan Jia, Chaowan Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Basis Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2021.166106"}], "href": "https://doi.org/10.1016/j.bbadis.2021.166106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33631320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33631320"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Nassima Temime-Smaali, Lionel Guittat, Assitan Sidibe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0006919"}], "href": "https://doi.org/10.1371/journal.pone.0006919"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19742304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19742304"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Karin Broberg, Elizabeth Huynh, Karin Schläwicke Engström, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-9-140"}], "href": "https://doi.org/10.1186/1471-2407-9-140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19432957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19432957"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Alexandre de Nonneville, Sébastien Salas, François Bertucci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.202215859"}], "href": "https://doi.org/10.15252/emmm.202215859"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35920001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35920001"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hung-Ji Tsai, Wei-Hsiang Huang, Tsai-Kun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of topoisomerase III in telomere-telomere recombination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M600649200"}], "href": "https://doi.org/10.1074/jbc.M600649200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16546998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16546998"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Arun Pradhan, Thiyam Ramsing Singh, Abdullah Mahmood Ali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III α-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.470823"}], "href": "https://doi.org/10.1074/jbc.M113.470823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24108125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24108125"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "João Paulo Oliveira-Costa, Lucinei Roberto Oliveira, Giórgia Gobbi da Silveira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Topoisomerase expression in oral squamous cell carcinoma: relationship with cancer stem cells profiles and lymph node metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oral Pathol Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0714.2012.01174.x"}], "href": "https://doi.org/10.1111/j.1600-0714.2012.01174.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22672768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22672768"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Katja E Menger, James Chapman, Héctor Díaz-Maldonado, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two type I topoisomerases maintain DNA topology in human mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkac857"}], "href": "https://doi.org/10.1093/nar/gkac857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36215039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36215039"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Mei-Yi Hsieh, Jia-Rong Fan, Han-Wen Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA topoisomerase III alpha regulates p53-mediated tumor suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-13-1997"}], "href": "https://doi.org/10.1158/1078-0432.CCR-13-1997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24526736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24526736"}]}]}]}
Synonyms	ZGRF7, MGRISCE2, TOP3, PEOB5
Proteins	TOP3A_HUMAN
NCBI Gene ID	7156
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TOP3A has 6,563 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for TOP3A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TOP3A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TOP3A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TOP3A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TOP3A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TOP3A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TOP3A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TOP3A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TOP3A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TOP3A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TOP3A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TOP3A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TOP3A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TOP3A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TOP3A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TOP3A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TOP3A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TOP3A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TOP3A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TOP3A gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TOP3A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TOP3A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TOP3A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TOP3A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TOP3A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TOP3A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TOP3A protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TOP3A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TOP3A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TOP3A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TOP3A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TOP3A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TOP3A gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TOP3A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TOP3A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TOP3A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TOP3A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TOP3A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TOP3A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TOP3A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TOP3A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TOP3A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.