TOPBP1 Gene

Name	topoisomerase (DNA) II binding protein 1
Description	This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTOPBP1 is a multifunctional scaffold protein defined by multiple BRCT domains that plays a central role in preserving genome integrity. It is essential for initiating ATR‐dependent checkpoint signaling by directly stimulating ATR kinase activity and by mediating recruitment of ATR together with its partner ATRIP to sites of damaged or stalled replication forks. TOPBP1 orchestrates the assembly of distinct nuclear foci that incorporate key checkpoint factors—including Rad9, Claspin, and the 9–1–1 complex—to enable efficient Chk1 phosphorylation and enforce proper cell cycle arrest under genotoxic stress. In addition, TOPBP1 interacts with viral regulatory proteins (for example, HPV16 E2) and modulates transcription and replication in both viral and cellular contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its checkpoint‐activating functions, TOPBP1 is crucial for proper DNA repair and homologous recombination. It facilitates RAD51 recruitment—often via interactions that promote its phosphorylation—and collaborates with proteins such as BACH1, MDC1, and even mutant p53 to regulate DNA double‐strand break repair and to stabilize replication forks, thereby preventing the accumulation of deleterious lesions. Loss or deregulation of TOPBP1 not only impairs DNA replication and cell proliferation (as revealed by conditional knockout studies) but also may contribute to oncogenic processes through defective p53 regulation. Moreover, through its engagement with viral factors, TOPBP1 influences viral genome replication and transcription. These multifaceted roles underscore TOPBP1’s importance in sustaining chromosomal stability and cellular viability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Winifred Boner, Ewan R Taylor, Emmanouella Tsirimonaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M202163200"}], "href": "https://doi.org/10.1074/jbc.M202163200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11934899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11934899"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhi-Xiang Xu, Anna Timanova-Atanasova, Rui-Xun Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PML colocalizes with and stabilizes the DNA damage response protein TopBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.12.4247-4256.2003"}], "href": "https://doi.org/10.1128/MCB.23.12.4247-4256.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12773567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12773567"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kazuhiko Yamane, Junjie Chen, Timothy J Kinsella "}, {"type": "b", "children": [{"type": "t", "text": "Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12810625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12810625"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Deborah A Greer, Blair D A Besley, Katherine B Kennedy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12941802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12941802"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ja-Eun Kim, Sarah A McAvoy, David I Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human TopBP1 ensures genome integrity during normal S phase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.24.10907-10915.2005"}], "href": "https://doi.org/10.1128/MCB.25.24.10907-10915.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16314514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16314514"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Akiko Kumagai, Joon Lee, Hae Yong Yoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TopBP1 activates the ATR-ATRIP complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2005.12.041"}], "href": "https://doi.org/10.1016/j.cell.2005.12.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16530042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16530042"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Shizhou Liu, Simon Bekker-Jensen, Niels Mailand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00492-06"}], "href": "https://doi.org/10.1128/MCB.00492-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16880517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16880517"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mary M Donaldson, Winifred Boner, Iain M Morgan "}, {"type": "b", "children": [{"type": "t", "text": "TopBP1 regulates human papillomavirus type 16 E2 interaction with chromatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02353-06"}], "href": "https://doi.org/10.1128/JVI.02353-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17287259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17287259"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Daniel A Mordes, Gloria G Glick, Runxiang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TopBP1 activates ATR through ATRIP and a PIKK regulatory domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1666208"}], "href": "https://doi.org/10.1101/gad.1666208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18519640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18519640"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kang Liu, Naresh Bellam, Hui-Yi Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01140-08"}], "href": "https://doi.org/10.1128/MCB.01140-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19289498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19289498"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yiyong Liu, Yanan Fang, Hongbing Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.076109"}], "href": "https://doi.org/10.1074/jbc.M109.076109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20029092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20029092"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Zihua Gong, Ja-Eun Kim, Charles Chung Yun Leung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2010.01.002"}], "href": "https://doi.org/10.1016/j.molcel.2010.01.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20159562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20159562"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mathieu Rappas, Antony W Oliver, Laurence H Pearl "}, {"type": "b", "children": [{"type": "t", "text": "Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkq743"}], "href": "https://doi.org/10.1093/nar/gkq743"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20724438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20724438"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yoon Jeon, Eun Ko, Kyung Yong Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.189704"}], "href": "https://doi.org/10.1074/jbc.M110.189704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21149450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21149450"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jiadong Wang, Zihua Gong, Junjie Chen "}, {"type": "b", "children": [{"type": "t", "text": "MDC1 collaborates with TopBP1 in DNA replication checkpoint control."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201010026"}], "href": "https://doi.org/10.1083/jcb.201010026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21482717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21482717"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Kang Liu, Shiyun Ling, Weei-Chin Lin "}, {"type": "b", "children": [{"type": "t", "text": "TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.05574-11"}], "href": "https://doi.org/10.1128/MCB.05574-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21930790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21930790"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Elaine J Gauson, Mary M Donaldson, Edward S Dornan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence supporting a role for TopBP1 and Brd4 in the initiation but not continuation of human papillomavirus 16 E1/E2-mediated DNA replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00335-15"}], "href": "https://doi.org/10.1128/JVI.00335-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25694599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25694599"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ronan Broderick, Jadwiga Nieminuszczy, Andrew N Blackford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7572"}], "href": "https://doi.org/10.1038/ncomms7572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25762097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25762097"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Pavel Moudry, Kenji Watanabe, Kamila M Wolanin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201507042"}], "href": "https://doi.org/10.1083/jcb.201507042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26811421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26811421"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Pia-Amata Leimbacher, Samuel E Jones, Ann-Marie K Shorrocks, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2019.02.014"}], "href": "https://doi.org/10.1016/j.molcel.2019.02.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30898438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30898438"}]}]}]}
Synonyms	TOP2BP1, Dpb11
Proteins	TOPB1_HUMAN
NCBI Gene ID	11073
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TOPBP1 has 8,360 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for TOPBP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TOPBP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TOPBP1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TOPBP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TOPBP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TOPBP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TOPBP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TOPBP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TOPBP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TOPBP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TOPBP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TOPBP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TOPBP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TOPBP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TOPBP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with TOPBP1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TOPBP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TOPBP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TOPBP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TOPBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TOPBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TOPBP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TOPBP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TOPBP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TOPBP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TOPBP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TOPBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TOPBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TOPBP1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TOPBP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TOPBP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TOPBP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TOPBP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TOPBP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TOPBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TOPBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TOPBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TOPBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TOPBP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TOPBP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TOPBP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TOPBP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.