{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTPI1P2 appears to act as an anti‐inflammatory regulator in metabolic tissues. In adipose tissue, its activity (as evidenced by its correlation with miR‐1934 expression) is modulated by adiponectin and is notably reduced in obesity. Reduced levels of TPI1P2 are associated with an enhanced inflammatory state in both mouse and human adipose depots, where low expression correlates with increased circulating markers of inflammation and adverse metabolic parameters. In cellular models, overexpression of TPI1P2 (via its miR‐1934 component) counteracts TNF‐α–induced upregulation of cytokines such as IL-6 and MCP-1, thereby establishing a role for TPI1P2 in dampening inflammatory responses in adipocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its function in adipose tissue, TPI1P2 is implicated in hepatic metabolic regulation. In hepatocytes, interaction with the long non‐coding RNA Tug1 modulates the availability of mature TPI1P2 (reflected by miR‐1934-3p levels), which in turn represses the expression of targets such as Selenoprotein F. This regulation affects key metabolic pathways, notably by influencing glycolytic enzyme and fatty acid synthetase expression via the IRS1/AKT signaling cascade, thereby mitigating hepatocyte steatosis and abnormal glucolipid metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lulu Liu, Qifu Li, Xiaoqiu Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1934, downregulated in obesity, protects against low-grade inflammation in adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2016.03.026"}], "href": "https://doi.org/10.1016/j.mce.2016.03.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27013351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27013351"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Wang, Zhiruo Miao, Xue Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes via sponging miR-1934-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10565-023-09826-5"}], "href": "https://doi.org/10.1007/s10565-023-09826-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37721623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37721623"}]}]}]}