TPM1 Gene

HGNC Family	Tropomyosins (TPM)
Name	tropomyosin 1 (alpha)
Description	This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTropomyosin‐1 (TPM1) encodes a key α‐helical coiled‐coil protein that decorates the actin filament in striated muscle, where it governs the Ca²⁺–regulated interaction between actin and myosin. Mutations in TPM1 have been shown to alter myofilament Ca²⁺ sensitivity and disrupt contractile dynamics, thereby contributing to a spectrum of cardiomyopathies—including hypertrophic, dilated, and restrictive forms—and affecting both systolic and diastolic function. Studies in animal models and family‐based genetic screenings have directly linked specific TPM1 variants (for example, E180G, D175N, and others) to structural and functional myocardial alterations that predispose to adverse cardiac remodeling and heart failure."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its indispensable role in muscle contraction, TPM1 is crucial for organizing the actin cytoskeleton in various cell types. Post‐translational modifications—such as phosphorylation mediated by signaling pathways including ERK and DAP kinase—as well as alternative pre‐mRNA splicing regulated by RNA‐binding proteins (for example, RBM4) or long noncoding RNAs, yield tissue‐ and context‐specific TPM1 isoforms. These processes modulate the formation of stress fibers, focal adhesions, and lamellipodial actin networks, thereby influencing cell shape, adhesion, and migration. Moreover, interactions between TPM1 and other cytoskeletal regulators further orchestrate essential mechanotransduction events."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlterations in TPM1 expression and regulation extend into the realm of oncogenesis. In several malignancies—including breast and gastric cancers—epigenetic downregulation and microRNA–mediated silencing of TPM1 have been observed, events that correlate with cytoskeletal destabilization, resistance to apoptosis (for example, through diminished anoikis), and enhanced cellular migration. Such findings not only underscore the tumor–suppressive properties of TPM1 but also highlight its promise as a diagnostic biomarker and potential therapeutic target in neoplastic disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Daniel E Michele, Carlen A Gomez, Katie E Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.res.0000027530.58419.82"}], "href": "https://doi.org/10.1161/01.res.0000027530.58419.82"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12169652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12169652"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sara L Van Driest, Michael J Ackerman, Steve R Ommen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prevalence and severity of \"benign\" mutations in the beta-myosin heavy chain, cardiac troponin T, and alpha-tropomyosin genes in hypertrophic cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.cir.0000042675.59901.14"}], "href": "https://doi.org/10.1161/01.cir.0000042675.59901.14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12473556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12473556"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mahmooda Mirza, Paul Robinson, Elena Kremneva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M701071200"}], "href": "https://doi.org/10.1074/jbc.M701071200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17360712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17360712"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Paul Robinson, Peter J Griffiths, Hugh Watkins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.107.156380"}], "href": "https://doi.org/10.1161/CIRCRESAHA.107.156380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17932326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17932326"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Daniel Vega Møller, Paal Skytt Andersen, Paula Hedley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2009.34"}], "href": "https://doi.org/10.1038/ejhg.2009.34"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19293840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19293840"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sudarsan Rajan, Ganapathy Jagatheesan, Chehade N Karam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.109.889725"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.109.889725"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20065163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20065163"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Charles Redwood, Paul Robinson "}, {"type": "b", "children": [{"type": "t", "text": "Alpha-tropomyosin mutations in inherited cardiomyopathies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Muscle Res Cell Motil (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10974-013-9358-5"}], "href": "https://doi.org/10.1007/s10974-013-9358-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24005378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24005378"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tejas M Gupte, Farah Haque, Binnu Gangadharan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.596676"}], "href": "https://doi.org/10.1074/jbc.M114.596676"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25548289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25548289"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Alexander M Matyushenko, Daniil V Shchepkin, Galina V Kopylova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and Functional Effects of Cardiomyopathy-Causing Mutations in the Troponin T-Binding Region of Cardiac Tropomyosin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.6b00994"}], "href": "https://doi.org/10.1021/acs.biochem.6b00994"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27983818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27983818"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jennifer England, Javier Granados-Riveron, Luis Polo-Parada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tropomyosin 1: Multiple roles in the developing heart and in the formation of congenital heart defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2017.03.006"}], "href": "https://doi.org/10.1016/j.yjmcc.2017.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28359939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28359939"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Norma J Greenfield, Velia M Fowler "}, {"type": "b", "children": [{"type": "t", "text": "Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biophys J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0006-3495(02)75600-2"}], "href": "https://doi.org/10.1016/S0006-3495(02"}, {"type": "t", "text": "75600-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11964245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11964245"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "François Houle, Simon Rousseau, Nick Morrice, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e02-04-0235"}], "href": "https://doi.org/10.1091/mbc.e02-04-0235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12686598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12686598"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jung-Chun Lin, Woan-Yuh Tarn "}, {"type": "b", "children": [{"type": "t", "text": "Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.22.10111-10121.2005"}], "href": "https://doi.org/10.1128/MCB.25.22.10111-10121.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16260624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16260624"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "François Houle, Andrée Poirier, Jeannot Dumaresq, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DAP kinase mediates the phosphorylation of tropomyosin-1 downstream of the ERK pathway, which regulates the formation of stress fibers in response to oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.003251"}], "href": "https://doi.org/10.1242/jcs.003251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17895359"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17895359"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hsin-Yao Tang, Lynn A Beer, Janos L Tanyi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein isoform-specific validation defines multiple chloride intracellular channel and tropomyosin isoforms as serological biomarkers of ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteomics (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jprot.2013.06.016"}], "href": "https://doi.org/10.1016/j.jprot.2013.06.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23792823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23792823"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Simon Brayford, Nicole S Bryce, Galina Schevzov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2016.03.028"}], "href": "https://doi.org/10.1016/j.cub.2016.03.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27112294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27112294"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Guo-Wei Huang, Ying-Li Zhang, Lian-Di Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Natural antisense transcript TPM1-AS regulates the alternative splicing of tropomyosin I through an interaction with RNA-binding motif protein 4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2017.07.017"}], "href": "https://doi.org/10.1016/j.biocel.2017.07.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28754317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28754317"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jun Lin, Juan Shen, Hao Yue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA‑183‑5p.1 promotes the migration and invasion of gastric cancer AGS cells by targeting TPM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.7354"}], "href": "https://doi.org/10.3892/or.2019.7354"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31638242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31638242"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Shantaram Bharadwaj, G L Prasad "}, {"type": "b", "children": [{"type": "t", "text": "Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0304-3835(02)00119-2"}], "href": "https://doi.org/10.1016/s0304-3835(02"}, {"type": "t", "text": "00119-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12065096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12065096"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Gira N Raval, Shantaram Bharadwaj, Edward A Levine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206719"}], "href": "https://doi.org/10.1038/sj.onc.1206719"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "13679858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/13679858"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Eri Kubo, Nailia Hasanova, Nigar Fatma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1582-4934.2012.01654.x"}], "href": "https://doi.org/10.1111/j.1582-4934.2012.01654.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23205574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23205574"}]}]}]}
Synonyms	CMH3, HTM-ALPHA, LVNC9, C15ORF13, CMD1Y, HEL-S-265
Proteins	TPM1_HUMAN
NCBI Gene ID	7168
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TPM1 has 18,657 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 139 datasets.

Click the + buttons to view associations for TPM1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TPM1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TPM1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TPM1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TPM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TPM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TPM1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TPM1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TPM1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TPM1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TPM1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TPM1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TPM1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TPM1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TPM1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TPM1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TPM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TPM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TPM1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TPM1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TPM1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TPM1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TPM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TPM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TPM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TPM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TPM1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TPM1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TPM1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TPM1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TPM1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TPM1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TPM1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving TPM1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TPM1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TPM1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TPM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TPM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TPM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TPM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TPM1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TPM1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.