TPR Gene

Name	translocated promoter region, nuclear basket protein
Description	This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTPR is a large, evolutionarily conserved nucleoporin that forms a central architectural element of the nuclear pore complex (NPC) by constituting the primary scaffold of the nuclear basket. Numerous studies have demonstrated that TPR not only supports the structural integrity and assembly of NPCs but also governs nucleocytoplasmic transport processes. In particular, evidence shows that TPR anchors key proteins such as Nup153 to the NPC, thereby linking the pore’s core to the nuclear interior and establishing specialized subdomains that exclude heterochromatin and ensure proper mRNA processing. Moreover, TPR facilitates the selective export of mRNAs—including heat shock transcripts—and participates in mRNA quality control, preferentially promoting the export of intronless or intron‐poor transcripts and regulating the export of unspliced RNAs."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its transport and structural roles, TPR is a critical regulator of cell cycle and genome integrity. It directly interacts with spindle assembly checkpoint proteins such as Mad1 and Mad2 and with mitotic kinases including Aurora A, thereby ensuring accurate chromosome segregation and centrosomal organization during mitosis. Post‐translational modifications of TPR, notably site‐specific phosphorylations, further modulate its interactions with key cell cycle regulators. TPR fusions with receptor tyrosine kinases (for example, FGFR1 and MET) have been implicated in oncogenic transformation, and alterations in TPR expression or frameshift mutations correlate with disruption of nuclear envelope organization, deregulated autophagy, and poor prognosis in various cancers including ependymomas, colorectal carcinomas, and others. Moreover, studies in yeast homologs of TPR (Mlp1/Mlp2) indicate a conserved role in regulating tRNA export and cellular protein synthesis, underscoring TPR’s broad impact on gene expression and cell proliferation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sandra Krull, Johan Thyberg, Birgitta Björkroth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e04-03-0165"}], "href": "https://doi.org/10.1091/mbc.e04-03-0165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15229283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15229283"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hollie S Skaggs, Hongyan Xing, Donald C Wilkerson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HSF1-TPR interaction facilitates export of stress-induced HSP70 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M704054200"}], "href": "https://doi.org/10.1074/jbc.M704054200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17897941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17897941"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Katherine Karakoula, Blanca Suarez-Merino, Samantha Ward, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Real-time quantitative PCR analysis of pediatric ependymomas identifies novel candidate genes including TPR at 1q25 and CHIBBY at 22q12-q13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20607"}], "href": "https://doi.org/10.1002/gcc.20607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18663750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18663750"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sandra Krull, Julia Dörries, Björn Boysen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2010.54"}], "href": "https://doi.org/10.1038/emboj.2010.54"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20407419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20407419"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "John H Coyle, Yeou-Cherng Bor, David Rekosh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.2616111"}], "href": "https://doi.org/10.1261/rna.2616111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21613532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21613532"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Brigitte David-Watine "}, {"type": "b", "children": [{"type": "t", "text": "Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0022423"}], "href": "https://doi.org/10.1371/journal.pone.0022423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21811608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21811608"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kalpana Rajanala, Vinay Kumar Nandicoori "}, {"type": "b", "children": [{"type": "t", "text": "Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0029921"}], "href": "https://doi.org/10.1371/journal.pone.0029921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22253824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22253824"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Eliza S Lee, Eric J Wolf, Sean S J Ihn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkaa919"}], "href": "https://doi.org/10.1093/nar/gkaa919"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33091126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33091126"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sang Hyun Lee, Harry Sterling, Alma Burlingame, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1677208"}], "href": "https://doi.org/10.1101/gad.1677208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18981471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18981471"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Feng Li, Yong-Ping Zhai, Yu-Mei Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel partner gene, TPR, fused to FGFR1 in 8p11 myeloproliferative syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.21973"}], "href": "https://doi.org/10.1002/gcc.21973"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22619110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22619110"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kalpana Rajanala, Anshuk Sarkar, Gagan Deep Jhingan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of nucleoporin Tpr governs its differential localization and is required for its mitotic function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.149112"}], "href": "https://doi.org/10.1242/jcs.149112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24938596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24938596"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Akiko Kobayashi, Chieko Hashizume, Takayuki Dowaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2015.1021518"}], "href": "https://doi.org/10.1080/15384101.2015.1021518"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25789545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25789545"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Aala Jaberi, Erika Hooker, Julie Guillemette, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Tpr and α-actinin-4 as two novel SLK-interacting proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2015.06.005"}], "href": "https://doi.org/10.1016/j.bbamcr.2015.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26094769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26094769"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Graciela López-Soop, Torunn Rønningen, Agnieszka Rogala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2017.1310350"}], "href": "https://doi.org/10.1080/15384101.2017.1310350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28379780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28379780"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kuntal Pal, Abhishek Bandyopadhyay, X Edward Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2017.04.015"}], "href": "https://doi.org/10.1016/j.str.2017.04.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28528776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28528776"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Charlene Boumendil, Priya Hari, Karl C F Olsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear pore density controls heterochromatin reorganization during senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.321117.118"}], "href": "https://doi.org/10.1101/gad.321117.118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30692205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30692205"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jindřiška Fišerová, Miloslava Maninová, Tomáš Sieger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear pore protein TPR associates with lamin B1 and affects nuclear lamina organization and nuclear pore distribution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-019-03037-0"}], "href": "https://doi.org/10.1007/s00018-019-03037-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30762072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30762072"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Firli Rahmah Primula Dewi, Shabierjiang Jiapaer, Akiko Kobayashi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1009899"}], "href": "https://doi.org/10.1371/journal.pgen.1009899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34793452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34793452"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Jingfang Lv, Wenbin Li, Xintong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of MKI67, TPR , and TCHH Mutations as Prognostic Biomarkers for Patients With Defective Mismatch Repair Colon Cancer Stage II/III."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Colon Rectum (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/DCR.0000000000002734"}], "href": "https://doi.org/10.1097/DCR.0000000000002734"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37643197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37643197"}]}]}]}
Proteins	TPR_HUMAN
NCBI Gene ID	7175
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TPR has 12,747 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 129 datasets.

Click the + buttons to view associations for TPR from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TPR Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TPR gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TPR gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TPR gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TPR gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TPR gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TPR gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TPR gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TPR gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TPR gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TPR gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TPR gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TPR gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TPR gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with TPR gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TPR protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TPR gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TPR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TPR gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TPR protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TPR gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TPR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TPR protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TPR protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TPR protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TPR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TPR protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TPR gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TPR gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TPR gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TPR gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving TPR gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TPR gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TPR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TPR gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TPR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TPR gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TPR gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TPR gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TPR gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TPR from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.