{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn glioma, TPTEP1 acts as a tumor‐suppressive long noncoding RNA by attenuating cancer stemness and radioresistance. Mechanistic studies showed that TPTEP1 increases the expression of MAPK14 via a competitive interaction with miR‑106a‑15p, thereby activating the P38 MAPK signaling pathway. This regulation ultimately suppresses glioma progression, and reduced expression of TPTEP1 associates with higher tumor grade and poorer prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn non‑small cell lung cancer (NSCLC), TPTEP1 is also markedly downregulated. Overexpression of TPTEP1 in NSCLC cells inhibits cell proliferation and triggers apoptosis. The underlying mechanism involves TPTEP1 acting as a molecular sponge for miR‑328‑5p, which leads to the upregulation of SRCIN1 and subsequent inactivation of Src and STAT3 signaling pathways. This highlights TPTEP1’s tumor‑suppressive function in NSCLC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nInvestigations into diabetic retinopathy (DR) have focused on the role of TPTEP1 as well. Although the precise mechanisms remain to be fully elucidated, emerging studies are examining how dysregulation of TPTEP1 may contribute to the vascular and cellular pathology observed in DR, suggesting a possible regulatory role in this diabetic complication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gastric cancer, current evidence indicates that the function of TPTEP1 has not yet been reported, uncovering an area for future research to determine whether TPTEP1 might also have clinical relevance in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn ovarian cancer, TPTEP1 is significantly downregulated compared with normal ovarian tissues. Functional studies reveal that TPTEP1 exerts its tumor‐suppressive effects by directly binding to the PTBP1 protein, which results in the inhibition of the PI3K/AKT signaling pathway. This leads to reduced cell proliferation, migration, and invasion, while promoting apoptosis. These findings point to the potential of TPTEP1 as both a prognostic biomarker and a therapeutic target in ovarian cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ting Tang, Ling-Xing Wang, Mei-Li Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA TPTEP1 inhibits stemness and radioresistance of glioma through miR‑106a‑5p‑mediated P38 MAPK signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11542"}], "href": "https://doi.org/10.3892/mmr.2020.11542"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33173989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33173989"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Feng Cao, Zhiguo Wang, Yong Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA TPTEP1 competitively sponges miR‑328‑5p to inhibit the proliferation of non‑small cell lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2020.7522"}], "href": "https://doi.org/10.3892/or.2020.7522"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32323798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32323798"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoping Sun, Yuebing Lu, Tao Lei "}, {"type": "b", "children": [{"type": "t", "text": "TPTEP1 suppresses high glucose-induced dysfunction in retinal vascular endothelial cells by interacting with STAT3 and targeting VEGFA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Diabetol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00592-020-01663-w"}], "href": "https://doi.org/10.1007/s00592-020-01663-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33576890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33576890"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xinfa Wang, Xianbo Zhou, Fang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA TPTEP1 suppresses diabetic retinopathy by reducing oxidative stress and targeting the miR-489-3p/NRF2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Pol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18388/abp.2020_6034"}], "href": "https://doi.org/10.18388/abp.2020_6034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36795778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36795778"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "You Huang, Jun Wang, Hangsheng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TPTEP1 inhibits the migration and invasion of gastric cancer cells through miR-548d-3p/KLF9/PER1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2022.154054"}], "href": "https://doi.org/10.1016/j.prp.2022.154054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35985238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35985238"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yifan Feng, Zhe Zhang, Huijun Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA TPTEP1 suppresses PI3K/AKT signalling and inhibits ovarian cancer progression by interacting with PTBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.70106"}], "href": "https://doi.org/10.1111/jcmm.70106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39422584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39422584"}]}]}]}