TRAF3IP3 Gene

Name	TRAF3 interacting protein 3
Description	The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRAF3IP3 was originally identified as an adapter protein (also known as T3JAM) that interacts specifically with TRAF3 to regulate intracellular signaling cascades. Notably, it modulates the c-Jun N-terminal kinase (JNK) pathway by recruiting TRAF3 into subcellular compartments that favor JNK activation, a mechanism that extends to its role in antiviral signaling where TRAF3IP3 facilitates the recruitment of TRAF3 to the mitochondrial MAVS complex to trigger TBK1-IRF3–mediated interferon production. In addition, high-throughput functional screening has demonstrated that TRAF3IP3 can stimulate cell proliferation via modulation of the JNK pathway, with RNA interference experiments confirming its physiological necessity in this process."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its regulatory role in signal transduction and cell growth, TRAF3IP3 has been implicated in various pathological contexts. Elevated expression in certain tumors, notably melanoma, associates with enhanced tumor growth, increased cell viability, reduced apoptosis, and augmented angiogenesis. Moreover, genetic studies have identified TRAF3IP3 as an independent susceptibility gene in orofacial cleft formation and as a potential contributor to autoimmune conditions such as Graves’ disease, with additional investigations hinting at its involvement in hematologic malignancies. These findings underscore the broad biological and clinical relevance of TRAF3IP3 in immunity, development, and cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hajir Dadgostar, Sean E Doyle, Arash Shahangian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-5793(03)01072-x"}], "href": "https://doi.org/10.1016/s0014-5793(03"}, {"type": "t", "text": "01072-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14572659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14572659"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wenting Zhu, Jiaxin Li, Rui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2019102075"}], "href": "https://doi.org/10.15252/embj.2019102075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31390091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31390091"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xi Ma, Xinyu Wang, Xia Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of five human novel genes associated with cell proliferation by cell-based screening from an expressed cDNA ORF library."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2007.08.006"}], "href": "https://doi.org/10.1016/j.lfs.2007.08.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17868742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17868742"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Patrick Nasarre, Ingrid V Bonilla, John S Metcalf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRAF3-interacting protein 3, a new oncotarget, promotes tumor growth in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Melanoma Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CMR.0000000000000440"}], "href": "https://doi.org/10.1097/CMR.0000000000000440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29553967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29553967"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yunju Yang, Akiko Suzuki, Junichi Iwata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secondary Genome-Wide Association Study Using Novel Analytical Strategies Disentangle Genetic Components of Cleft Lip and/or Cleft Palate in 1q32.2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes11111280"}], "href": "https://doi.org/10.3390/genes11111280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33137956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33137956"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Guorong Yang, Shu Tang, Jie Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High TRAF3IP3 Level Predicts Poor Prognosis of Patients with Gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World Neurosurg (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.wneu.2021.01.006"}], "href": "https://doi.org/10.1016/j.wneu.2021.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33444836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33444836"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lauren Pommert, Robert Burns, Quinlan Furumo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel germline TRAF3IP3 mutation in a dyad with familial acute B lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Rep (Hoboken) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cnr2.1335"}], "href": "https://doi.org/10.1002/cnr2.1335"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33503336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33503336"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wei Li, Haidong Jiang, Xu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves' disease in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000031501"}], "href": "https://doi.org/10.1097/MD.0000000000031501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36397361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36397361"}]}]}]}
Synonyms	T3JAM
Proteins	T3JAM_HUMAN
NCBI Gene ID	80342
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TRAF3IP3 has 5,064 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for TRAF3IP3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TRAF3IP3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRAF3IP3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRAF3IP3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TRAF3IP3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TRAF3IP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TRAF3IP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRAF3IP3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TRAF3IP3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRAF3IP3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TRAF3IP3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRAF3IP3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TRAF3IP3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TRAF3IP3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TRAF3IP3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRAF3IP3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TRAF3IP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TRAF3IP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TRAF3IP3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TRAF3IP3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TRAF3IP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TRAF3IP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TRAF3IP3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TRAF3IP3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TRAF3IP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TRAF3IP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRAF3IP3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TRAF3IP3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TRAF3IP3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TRAF3IP3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TRAF3IP3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TRAF3IP3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TRAF3IP3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TRAF3IP3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TRAF3IP3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TRAF3IP3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TRAF3IP3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TRAF3IP3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRAF3IP3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TRAF3IP3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GAD Gene-Disease Associations	diseases associated with TRAF3IP3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of TRAF3IP3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.