{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTREX2 functions as a key component of the TREX‐2 complex that couples transcription with mRNA processing and export. In this context, TREX2 helps organize messenger ribonucleoprotein particles and promotes their efficient transit from transcription sites to the nuclear pore complex. Its stable association with nuclear pore basket proteins and interaction with factors such as the origin recognition complex indicate that TREX2 plays a role in linking gene expression to nuclear architecture, thereby contributing indirectly to genome stability by preventing RNA-mediated genotoxic stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in RNA export, TREX2 acts as an autonomous, nonprocessive 3′→5′ exonuclease that is essential for proper DNA end processing and genome maintenance. Structural and kinetic studies have revealed that TREX2 forms a dimer with symmetrically arranged active sites that efficiently remove 3′-mismatched nucleotides and assist in processing DNA termini. Mutation analyses have demonstrated that defects in TREX2’s catalytic and DNA-binding domains lead to impaired DNA repair, resulting in increased double-strand breaks, chromosomal fragments, and rearrangements. Moreover, TREX2 has been implicated in suppressing replication stress (including that arising from UV-induced lesions) and maintaining the appropriate balance of posttranslational modifications on histones during repair, while genetic and epigenetic studies underscore its relevance in human pathologies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David Umlauf, Jacques Bonnet, François Waharte, et al. 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