TRGC2 Gene

HGNC Family	T cell receptors (TR)
Name	T cell receptor gamma constant 2
Description	Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in T cell receptor signaling pathway and adaptive immune response. Predicted to be located in plasma membrane. Predicted to be part of gamma-delta T cell receptor complex. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Synonyms	TRGC2(3X), TRGC2(2X), TCRGC2
Proteins	TRGC2_HUMAN
NCBI Gene ID	6967
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TRGC2 has 712 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.

Click the + buttons to view associations for TRGC2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TRGC2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	CellMarker Gene-Cell Type Associations	cell types associated with TRGC2 gene from the CellMarker Gene-Cell Type Associations dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TRGC2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TRGC2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRGC2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TRGC2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing TRGC2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TRGC2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GO Biological Process Annotations 2023	biological processes involving TRGC2 gene from the curated GO Biological Process Annotations 2023 dataset.
	GO Cellular Component Annotations 2023	cellular components containing TRGC2 protein from the curated GO Cellular Component Annotations 2023 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of TRGC2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TRGC2 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	GTEx Tissue-Specific Aging Signatures	tissue samples with high or low expression of TRGC2 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
	HuBMAP Azimuth Cell Type Annotations	cell types associated with TRGC2 gene from the HuBMAP Azimuth Cell Type Annotations dataset.
	MGI Mouse Phenotype Associations 2023	phenotypes of transgenic mice caused by TRGC2 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of TRGC2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	cell types and tissues with high or low DNA methylation of TRGC2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores	tissues with high expression of TRGC2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with TRGC2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.