{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA detailed review of the provided abstracts (for example"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "reveals an extensive focus on the roles of E-type cyclins—particularly cyclin E1 and cyclin E2—in diverse cellular processes such as cell cycle reentry from quiescence, endoreplication in specialized cells, centrosome duplication, maintenance of chromosomal stability, and even cell cycle–independent functions in postmitotic neurons. These studies collectively emphasize how cyclin E, often in partnership with cyclin‐dependent kinases (most notably CDK2), not only drives the G1/S transition by promoting MCM loading and the assembly of DNA replication complexes but also influences tumorigenesis, tissue regeneration, and cellular responses to genotoxic stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, however, none of these abstracts make reference to TRHDE. While TRHDE is known from other literature to encode the thyrotropin‐releasing hormone–degrading enzyme and has been implicated in modulating neuropeptide signaling, the collection of studies summarized here does not address or elucidate any function for TRHDE. 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"}, {"type": "b", "children": [{"type": "t", "text": "Kinase-independent function of cyclin E."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2006.11.029"}], "href": "https://doi.org/10.1016/j.molcel.2006.11.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17218276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17218276"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Junko Odajima, Zachary P Wills, Yasmine M Ndassa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2011.08.009"}], "href": "https://doi.org/10.1016/j.devcel.2011.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21944720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21944720"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Menglin Liu, Lianghui Zhang, Glenn Marsboom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sox17 is required for endothelial regeneration following inflammation-induced vascular injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-10134-y"}], "href": "https://doi.org/10.1038/s41467-019-10134-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31073164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31073164"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Alex C Minella, Keith R Loeb, Andrea Knecht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1650208"}], "href": "https://doi.org/10.1101/gad.1650208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18559482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18559482"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yan Ma, Steven Fiering, Candice Black, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0606537104"}], "href": "https://doi.org/10.1073/pnas.0606537104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17360482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17360482"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Roland Sonntag, Nives Giebeler, Yulia A Nevzorova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1807155115"}], "href": "https://doi.org/10.1073/pnas.1807155115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30150405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30150405"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Said Akli, Carolyn S Van Pelt, Tuyen Bui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-0599"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-0599"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17671189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17671189"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Audrey Roussel-Gervais, Steve Bilodeau, Sophie Vallette, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2010-0091"}], "href": "https://doi.org/10.1210/me.2010-0091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20660298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20660298"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hyeon-Woo Lee, Kyung-Ok Nam, Su-Jung Park, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Akt-mediated liver growth promotes induction of cyclin E through a novel translational mechanism and a p21-mediated cell cycle arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M702110200"}], "href": "https://doi.org/10.1074/jbc.M702110200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17517888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17517888"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Uta Kossatz, Kai Breuhahn, Benita Wolf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI41959"}], "href": "https://doi.org/10.1172/JCI41959"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20978349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20978349"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Khaled Aziz, Jazeel F Limzerwala, Ines Sturmlechner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2019.03.016"}], "href": "https://doi.org/10.1053/j.gastro.2019.03.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30878468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30878468"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Wei Wei, Wei-Ya Zhang, Jian-Bo Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The NF-κB-modulated microRNAs miR-195 and miR-497 inhibit myoblast proliferation by targeting Igf1r, Insr and cyclin genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.174235"}], "href": "https://doi.org/10.1242/jcs.174235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26567220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26567220"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yulong Liang, Hong Gao, Shiaw-Yih Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "siRNA-based targeting of cyclin E overexpression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0012860"}], "href": "https://doi.org/10.1371/journal.pone.0012860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20877462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20877462"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "David M Loeb, Dorian Korz, Michael Katsnelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin E is a target of WT1 transcriptional repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201336200"}], "href": "https://doi.org/10.1074/jbc.M201336200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11919196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11919196"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Alexia Eliades, Nikolaos Papadantonakis, Katya Ravid "}, {"type": "b", "children": [{"type": "t", "text": "New roles for cyclin E in megakaryocytic polyploidization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.102145"}], "href": "https://doi.org/10.1074/jbc.M110.102145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20392692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20392692"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Weimin Li, Shuhei Kotoshiba, Cyril Berthet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0804177106"}], "href": "https://doi.org/10.1073/pnas.0804177106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19129496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19129496"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Suparna Mazumder, Dragos Plesca, Alexandru Almasan "}, {"type": "b", "children": [{"type": "t", "text": "A jekyll and hyde role of cyclin E in the genotoxic stress response: switching from cell cycle control to apoptosis regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.6.12.4432"}], "href": "https://doi.org/10.4161/cc.6.12.4432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17581275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17581275"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Ronglin Xie, Ricardo Medina, Ying Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0905651106"}], "href": "https://doi.org/10.1073/pnas.0905651106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19590016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19590016"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Jonathan Choiniere, Jianguo Wu, Li Wang "}, {"type": "b", "children": [{"type": "t", "text": "Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.116.106757"}], "href": "https://doi.org/10.1124/mol.116.106757"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28003426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28003426"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Marat Shtutman, Tzippi Hershko, Adva Maissel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PKCeta associates with cyclin E/Cdk2 complex in serum-starved MCF-7 and NIH-3T3 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-4827(03)00087-9"}], "href": "https://doi.org/10.1016/s0014-4827(03"}, {"type": "t", "text": "00087-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12729791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12729791"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Junko Odajima, Siddharth Saini, Piotr Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1006429"}], "href": "https://doi.org/10.1371/journal.pgen.1006429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27828963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27828963"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Viviana E Hermosilla, Ginessa Salgado, Elizabeth Riffo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12308"}], "href": "https://doi.org/10.1002/1878-0261.12308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29689621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29689621"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Leonardo K Teixeira, Nina Carrossini, Cristiane Sécca, et al. 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