{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRIAP1, originally identified as a p53‐inducible cell survival factor (p53CSV), plays a critical role in modulating apoptotic responses. It functions by interacting with chaperones such as Hsp70 to inhibit the formation of the apoptosome and subsequent caspase‐9 activation, thereby promoting cell survival under conditions of low DNA damage and stress. In addition, TRIAP1 has been implicated in repressing the expression of cell‐cycle regulators, such as p21, fine‐tuning the balance between cell-cycle arrest and apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWithin the mitochondrial intermembrane space, TRIAP1 forms complexes with lipid transfer partners, including PRELI (and related proteins such as SLMO1), to facilitate the import and accumulation of key phospholipids like cardiolipin. This lipid-transfer activity is essential for maintaining the structural integrity of the mitochondrial inner membrane, preventing the release of cytochrome c and curbing the initiation of intrinsic apoptotic cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a variety of cancer contexts—including breast cancer, multiple myeloma, nasopharyngeal carcinoma, and non-small cell lung cancer—TRIAP1 is often overexpressed, which correlates with increased resistance to chemotherapeutic agents and radiotherapy. Its upregulation enhances tumor cell survival by attenuating mitochondrial cytochrome c release during drug-induced mitotic arrest, thereby diminishing caspase activation and facilitating the emergence of drug-resistant clones. This multifaceted role in apoptosis inhibition and modulation of mitochondrial function positions TRIAP1 as a prominent contributor to chemoresistance and aggressiveness in diverse malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Woong-Ryeon Park, Yusuke Nakamura "}, {"type": "b", "children": [{"type": "t", "text": "p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-04-3339"}], "href": "https://doi.org/10.1158/0008-5472.CAN-04-3339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15735003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15735003"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Roberta S Felix, Gisele W B Colleoni, Otavia L Caballero, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2013.07.008"}], "href": "https://doi.org/10.1016/j.cmet.2013.07.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23931759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23931759"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xeni Miliara, James A Garnett, Takashi Tatsuta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201540229"}], "href": "https://doi.org/10.15252/embr.201540229"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26071602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26071602"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Caroline Adams, Giulia Cazzanelli, Sabeena Rasul, et al. 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