TRIM2 Gene

HGNC Family	Zinc fingers, Tripartite motif-containing (TRIM)
Name	tripartite motif containing 2
Description	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTripartite motif‐containing protein 2 (TRIM2) is a member of the TRIM‐NHL family that functions as an E3 ubiquitin ligase and plays key roles in neuronal development and homeostasis. In the brain it is subject to regulation by microRNAs – for example, miR‑9 and miR‑181c have been shown to repress its 3′ UTR, implying that deregulation of TRIM2 may contribute to neurodegenerative disorders, including Alzheimer’s disease (21720722). Structural studies of its NHL domain have provided insights into its molecular architecture and self‐association properties (24817735), while clinical reports have linked mutations in TRIM2 with early‐onset axonal neuropathies such as Charcot–Marie–Tooth disease (25893792). Reviews of the TRIM‑NHL family further emphasize the importance of TRIM2 in neuronal differentiation and the regulation of cell growth (26514622), and recent comprehensive surveys highlight its roles in neuroprotection and neural ischemic responses (36051486). Detailed structure–function analyses comparing TRIM2 with paralogous proteins also demonstrate that subtle sequence differences can dramatically affect its activity (36481767)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its neural functions, TRIM2 has been implicated as a promoter of tumor progression in several malignancies. Elevated TRIM2 expression supports oncogenic processes in osteosarcoma by enhancing cell viability, migration, and invasion via activation of the phosphoinositide‑3‑kinase/protein kinase B (PI3K/AKT) signaling pathway (30066883), in colorectal cancer by facilitating epithelial–mesenchymal transition (30916596), in pancreatic cancer through amplification of reactive oxygen species (ROS)‑related NRF2/antioxidant response and integrin/FAK signaling (32929153), and in neuroblastoma where upregulation via a competing endogenous RNA network promotes malignant behavior and glycolytic metabolism (36920626). Furthermore, TRIM2 has been shown to be necessary for endothelial cell tubulogenesis in the context of hypoxia‐induced angiogenesis, pointing to its broader role in the regulation of the tumor microenvironment (29958463)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTRIM2 also fulfills diverse roles beyond neurobiology and cancer. It exerts antiviral effects by restricting the entry of New World arenaviruses, a process shown to occur independently of its ubiquitin ligase activity and involving interactions with proteins that regulate phagocytosis (30726215). In models of idiopathic pulmonary fibrosis, perturbations in noncoding RNA networks result in altered TRIM2 levels, thereby modulating cellular proliferation, migration, and epithelial–mesenchymal transition in lung tissues (33760118). Collectively, these findings illustrate the context‑dependent versatility of TRIM2 in processes ranging from antiviral defense and angiogenesis to tissue remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ""}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nicole Schonrock, David T Humphreys, Thomas Preiss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-011-9587-2"}], "href": "https://doi.org/10.1007/s12031-011-9587-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21720722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21720722"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaotao Guan, Jun Li, Xingru Lü, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal NHL domain of human TRIM2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Crystallogr F Struct Biol Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1107/S2053230X14008127"}], "href": "https://doi.org/10.1107/S2053230X14008127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24817735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24817735"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Davut Pehlivan, Zeynep Coban Akdemir, Ender Karaca, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing reveals homozygous TRIM2 mutation in a patient with early onset CMT and bilateral vocal cord paralysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-015-1548-3"}], "href": "https://doi.org/10.1007/s00439-015-1548-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25893792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25893792"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Cristina Tocchini, Rafal Ciosk "}, {"type": "b", "children": [{"type": "t", "text": "TRIM-NHL proteins in development and disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Semin Cell Dev Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.semcdb.2015.10.017"}], "href": "https://doi.org/10.1016/j.semcdb.2015.10.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26514622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26514622"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maolin Xiao, Jianjun Li, Qingyuan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and Role of TRIM2 in Human Diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/9430509"}], "href": "https://doi.org/10.1155/2022/9430509"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36051486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36051486"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Diego Esposito, Jane Dudley-Fraser, Acely Garza-Garcia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-35300-7"}], "href": "https://doi.org/10.1038/s41467-022-35300-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36481767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36481767"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yi Qin, Jichao Ye, Fulan Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM2 regulates the development and metastasis of tumorous cells of osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2018.4494"}], "href": "https://doi.org/10.3892/ijo.2018.4494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30066883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30066883"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hua Cao, Yi Fang, Qiwen Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM2 is a novel promoter of human colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Scand J Gastroenterol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/00365521.2019.1575463"}], "href": "https://doi.org/10.1080/00365521.2019.1575463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30916596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30916596"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Qiqing Sun, Zeng Ye, Yi Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-01452-3"}], "href": "https://doi.org/10.1038/s41388-020-01452-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32929153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32929153"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rongrong Lv, Fang Lu, Shanshan Xu "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Metab Brain Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11011-023-01197-4"}], "href": "https://doi.org/10.1007/s11011-023-01197-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36920626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36920626"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Nathan K P Wong, Helena Cheung, Emma L Solly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exploring the Roles of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "CREBRF"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TRIM2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in the Regulation of Angiogenesis by High-Density Lipoproteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms19071903"}], "href": "https://doi.org/10.3390/ijms19071903"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29958463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29958463"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nicolas Sarute, Nouhou Ibrahim, Bani Medegan Fagla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM2, a novel member of the antiviral family, limits New World arenavirus entry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.3000137"}], "href": "https://doi.org/10.1371/journal.pbio.3000137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30726215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30726215"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hengzhong Yi, Danlin Luo, Yangbao Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of long non‑coding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA‑369‑3p/TRIM2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2021.4913"}], "href": "https://doi.org/10.3892/ijmm.2021.4913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33760118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33760118"}]}]}]}
Synonyms	RNF86, CMT2R
Proteins	TRIM2_HUMAN
NCBI Gene ID	23321
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TRIM2 has 10,052 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for TRIM2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TRIM2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TRIM2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TRIM2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TRIM2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIM2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIM2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIM2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TRIM2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIM2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIM2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TRIM2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TRIM2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRIM2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TRIM2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TRIM2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TRIM2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TRIM2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TRIM2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TRIM2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TRIM2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TRIM2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TRIM2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TRIM2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TRIM2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIM2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TRIM2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TRIM2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TRIM2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TRIM2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TRIM2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TRIM2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving TRIM2 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TRIM2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TRIM2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TRIM2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TRIM2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TRIM2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TRIM2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.