{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRIM24 is a multifunctional chromatin regulator that functions as a dual histone‐mark reader through its tandem plant homeodomain and bromodomain architecture. This unique structural arrangement allows TRIM24 to preferentially bind to the unmodified histone H3 lysine 4 together with acetylated H3 lysine 23, thereby transducing specific chromatin modifications into a transcription‐activating signal. Such histone “reading” activity underpins its ability to serve as a co‐activator for nuclear receptors—including estrogen and androgen receptors—which, in turn, promote cell proliferation and tumor progression in hormone‐dependent cancers such as breast and prostate cancer, as well as in glioblastoma where it integrates oncogenic signals such as those emanating from EGFR and STAT3"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n\n<br><br>\nIn addition to its role as a chromatin reader, TRIM24 interacts with and modulates the activity of several critical transcription factors and co-regulators. It participates in the negative regulation of p53 by acting as an E3 ubiquitin ligase and, conversely, forms part of feedback loops with proteins such as TIP60 and TRIM28, which promote its stability and facilitate its occupancy on chromatin. These interactions are instrumental in regulating transcriptional elongation and cell cycle progression, thereby enhancing pro-survival and proliferative signaling in various tumor types including hepatocellular carcinoma, glioblastoma, and non-small cell lung cancer. Moreover, through its ability to recruit partners like STAT3 and to interface with elongation factors, TRIM24 helps propagate oncogenic transcriptional programs"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "12"}]}, {"type": "t", "text": "\n\n<br><br>\nBeyond its molecular functions in transcriptional regulation, TRIM24 has emerged as a robust prognostic indicator and a potential therapeutic target across a spectrum of human cancers. Elevated expression of TRIM24 is associated with aggressive tumor features—such as enhanced cell proliferation, invasion, drug resistance, and metabolic reprogramming—in head and neck, gastric, colorectal, bladder, esophageal, and ovarian cancers. Its deregulated expression not only correlates with unfavorable clinical outcomes but also modulates immune response pathways and resistance to standard chemotherapy. Collectively, these observations underscore the oncogenic potential of TRIM24 and support its candidacy as a biomarker for disease progression as well as a viable target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Misato Kikuchi, Fumihiko Okumura, Tadasuke Tsukiyama, et al. 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