TRIM27 Gene

HGNC Family	Tripartite motif-containing (TRIM), Zinc fingers
Name	tripartite motif containing 27
Description	This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRIM27 is a multifaceted E3 ubiquitin ligase that regulates diverse cellular processes. In endosomal protein trafficking, TRIM27 partners with MAGE‐L2 to mediate K63‐linked ubiquitination of key components such as WASH, thereby promoting endosomal F‐actin nucleation and retromer‐dependent retrograde transport."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the realm of innate immunity, TRIM27 functions as a negative regulator by several mechanisms. It binds directly to the nucleotide‐binding domain of NOD2 and triggers K48‐linked ubiquitination resulting in proteasomal degradation and diminished pro‐inflammatory signaling. Similarly, by associating with USP7, TRIM27 contributes to the ubiquitination and degradation of TBK1, thereby modulating interferon responses. Moreover, TRIM27 suppresses CD4 T cell activation via ubiquitination of PI3KC2β, and in macrophages it restricts mycobacterial survival by promoting innate immune responses and apoptosis—although its inhibitory effects can be countered by pathogen effectors. In psoriasis, TRIM27 ubiquitinates PIAS3, leading to enhanced STAT3 activation and amplification of inflammatory signals."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTRIM27 also plays diverse roles in cancer biology. It is involved in oncogenic RET fusions—such as the novel TRIM27‐RET transcript identified in apocrine intraductal carcinomas—which suggest a role in tumorigenesis through aberrant kinase activation. In addition, overexpression of TRIM27 in colorectal and ovarian cancers has been associated with enhanced epithelial–mesenchymal transition, increased cell proliferation, invasion, and metastasis through AKT activation and other signaling cascades. In other contexts, TRIM27 (also known as RFP) modulates gene transcription by interacting with the retinoblastoma protein, thereby inhibiting its transcription‐activating functions, and it may further influence cell death pathways in a manner that impacts tumor progression as seen in breast carcinoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence also suggests potential roles for TRIM27 in tissue injury—such as in hepatic ischemia–reperfusion—and in viral infections, which further underscores its importance as a context‐dependent regulator operating through distinct ubiquitination events. Collectively, TRIM27 fine‐tunes key signaling pathways in endosomal trafficking, innate immunity, and tumorigenesis, making it a promising target for therapeutic intervention in inflammatory diseases, infection, and cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi-Heng Hao, Jennifer M Doyle, Saumya Ramanathan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2013.01.051"}], "href": "https://doi.org/10.1016/j.cell.2013.01.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23452853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23452853"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Birte Zurek, Ida Schoultz, Andreas Neerincx, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0041255"}], "href": "https://doi.org/10.1371/journal.pone.0041255"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22829933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22829933"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Juan Cai, Hong-Yan Chen, Shu-Jie Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP7-TRIM27 axis negatively modulates antiviral type I IFN signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201700473RR"}], "href": "https://doi.org/10.1096/fj.201700473RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29688809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29688809"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xinjiang Cai, Shekhar Srivastava, Yi Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1111233109"}], "href": "https://doi.org/10.1073/pnas.1111233109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22128329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22128329"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jing Wang, Jade L L Teng, Dongdong Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep34827"}], "href": "https://doi.org/10.1038/srep34827"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27698396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27698396"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiao Miao, Yanwei Xiang, Weiwei Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM27 promotes IL-6-induced proliferation and inflammation factor production by activating STAT3 signaling in HaCaT cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00314.2019"}], "href": "https://doi.org/10.1152/ajpcell.00314.2019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31747314"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31747314"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Alena Skálová, Tomas Vanecek, Emmanuelle Uro-Coste, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular Profiling of Salivary Gland Intraductal Carcinoma Revealed a Subset of Tumors Harboring NCOA4-RET and Novel TRIM27-RET Fusions: A Report of 17 cases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0000000000001133"}], "href": "https://doi.org/10.1097/PAS.0000000000001133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30045065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30045065"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Alena Skálová, Nikola Ptáková, Thalita Santana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NCOA4-RET and TRIM27-RET Are Characteristic Gene Fusions in Salivary Intraductal Carcinoma, Including Invasive and Metastatic Tumors: Is \"Intraductal\" Correct?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0000000000001301"}], "href": "https://doi.org/10.1097/PAS.0000000000001301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31162284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31162284"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yue Zhang, Yifei Feng, Dongjian Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM27 functions as an oncogene by activating epithelial-mesenchymal transition and p-AKT in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2018.4408"}], "href": "https://doi.org/10.3892/ijo.2018.4408"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29767249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29767249"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yanyan Ma, Zengtao Wei, Robert C Bast, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of TRIM27 expression inhibits the proliferation of ovarian cancer cells in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.2015.132"}], "href": "https://doi.org/10.1038/labinvest.2015.132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26568293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26568293"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Maja Krützfeldt, Mark Ellis, Daniel B Weekes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective ablation of retinoblastoma protein function by the RET finger protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2005.03.009"}], "href": "https://doi.org/10.1016/j.molcel.2005.03.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15837424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15837424"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "So Hee Dho, Ki-Sun Kwon "}, {"type": "b", "children": [{"type": "t", "text": "The Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M304062200"}], "href": "https://doi.org/10.1074/jbc.M304062200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12807881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12807881"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sara E Conwell, Anne E White, J Wade Harper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of TRIM27 as a novel degradation target of herpes simplex virus 1 ICP0."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02635-14"}], "href": "https://doi.org/10.1128/JVI.02635-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25320289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25320289"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "San-Yang Chen, Hua-Peng Zhang, Jie Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tripartite Motif-Containing 27 Attenuates Liver Ischemia/Reperfusion Injury by Suppressing Transforming Growth Factor β-Activated Kinase 1 (TAK1) by TAK1 Binding Protein 2/3 Degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.31295"}], "href": "https://doi.org/10.1002/hep.31295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32343849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32343849"}]}]}]}
Synonyms	RFP, RNF76
Proteins	TRI27_HUMAN
NCBI Gene ID	5987
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TRIM27 has 5,693 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for TRIM27 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TRIM27 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TRIM27 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM27 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM27 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TRIM27 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TRIM27 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TRIM27 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM27 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIM27 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIM27 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIM27 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIM27 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIM27 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TRIM27 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TRIM27 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRIM27 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TRIM27 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TRIM27 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TRIM27 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TRIM27 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TRIM27 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TRIM27 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TRIM27 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TRIM27 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TRIM27 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIM27 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TRIM27 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with TRIM27 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TRIM27 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TRIM27 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving TRIM27 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TRIM27 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TRIM27 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TRIM27 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TRIM27 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TRIM27 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TRIM27 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TRIM27 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TRIM27 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRIM27 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TRIM27 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.