TRIM3 Gene

HGNC Family	Tripartite motif-containing (TRIM), Zinc fingers
Name	tripartite motif containing 3
Description	The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRIM3, a member of the TRIM‐NHL protein family and the human ortholog of Drosophila brain tumor (brat), plays a pivotal tumor‐suppressive role across a wide spectrum of malignancies. In glioblastoma, for example, TRIM3 restoration corrects defects in asymmetric cell division and dampens oncogenic drivers such as c‐Myc and Musashi–Notch signaling, thereby diminishing cancer stem cell properties. Similar tumor‐inhibitory functions of TRIM3 have been reported in hepatocellular carcinoma, cervical, colorectal, gastric, ovarian, and non‐small cell lung cancers, where its downregulation correlates with enhanced proliferation, increased resistance to apoptosis, and unfavorable clinical outcomes. In these contexts, TRIM3 modulates key signaling pathways—including the inactivation of p38 and PI3K/AKT cascades—and exerts its E3 ubiquitin ligase activity toward substrates such as SLC7A11, which regulates ferroptosis, and lactate dehydrogenase A, thereby impairing glycolytic flux that would otherwise fuel tumor growth."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in oncogenesis, TRIM3 contributes to the regulation of cellular signaling in non‐tumorous settings. In Parkinson’s disease models, up‐regulation of TRIM3 promotes PI3K/AKT pathway activation, which enhances cell viability while reducing reactive oxygen species, mitochondrial stress, and apoptosis. In the context of inflammatory joint disorders such as rheumatoid arthritis, TRIM3 expression in fibroblast‐like synoviocytes mitigates cell proliferation and inflammatory cytokine release—effects that are mediated partly via downregulation of p38 phosphorylation and interactions with transcriptional regulators like Foxo3a. Furthermore, TRIM3 has been shown to interact with components of the nuclear import machinery, thereby modulating NF‐κB activity and reinforcing its role as an important regulator of cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDetailed structural and mechanistic analyses have provided further insight into TRIM3’s function. Comparative studies with its paralog TRIM2 have revealed that subtle, placental mammal–specific amino acid changes—particularly adjacent to the core RING domain—can modulate TRIM3’s ability to self‐associate and engage E2 enzymes, thereby determining its ubiquitin ligase activity. Reviews encompassing TRIM–NHL proteins underscore that such structural nuances are critical for its regulation of developmental processes and tumor suppression, suggesting that targeted modulation of TRIM3’s domain interactions may hold therapeutic promise."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y Liu, R Raheja, N Yeh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.596"}], "href": "https://doi.org/10.1038/onc.2012.596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23318451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23318451"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gang Chen, Jun Kong, Carol Tucker-Burden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-13-3703"}], "href": "https://doi.org/10.1158/0008-5472.CAN-13-3703"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24947043"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24947043"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jie Chao, Xiao-Fei Zhang, Qiu-Zhong Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of TRIM3 is associated with poor prognosis in patients with primary hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0102-9"}], "href": "https://doi.org/10.1007/s12032-014-0102-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24994609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24994609"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mei-Yu Piao, Hai-Long Cao, Na-Na He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential role of TRIM3 as a novel tumour suppressor in colorectal cancer (CRC) development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Scand J Gastroenterol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/00365521.2015.1124285"}], "href": "https://doi.org/10.3109/00365521.2015.1124285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26691157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26691157"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Subhas Mukherjee, Carol Tucker-Burden, Changming Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-2299"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-2299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26893479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26893479"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xu-Qiong Huang, Xiao-Fei Zhang, Jin-Hua Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tripartite motif-containing 3 (TRIM3) inhibits tumor growth and metastasis of liver cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chin J Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40880-017-0240-5"}], "href": "https://doi.org/10.1186/s40880-017-0240-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28950898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28950898"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yu Song, Qisang Guo, Shujun Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tripartite motif-containing protein 3 plays a role of tumor inhibitor in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.03.046"}], "href": "https://doi.org/10.1016/j.bbrc.2018.03.046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29524410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29524410"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yu Song, Qisang Guo, Shujun Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.06.126"}], "href": "https://doi.org/10.1016/j.bbrc.2019.06.126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31270028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31270028"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Javad Farhadi, Ladan Goshayeshi, Alireza Motavalizadehkakhky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastrointest Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12029-020-00563-0"}], "href": "https://doi.org/10.1007/s12029-020-00563-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33415720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33415720"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zhangjie Wang, Na Shen, Ziao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-023-01239-5"}], "href": "https://doi.org/10.1038/s41418-023-01239-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37978273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37978273"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yu Cong, Xin Cui, Yaqian Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-023-04920-y"}], "href": "https://doi.org/10.1007/s11010-023-04920-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38367118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38367118"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wei Teng, Yuanguo Ling, Zongwei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Advances in the antitumor mechanisms of tripartite motif-containing protein 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-024-05632-6"}], "href": "https://doi.org/10.1007/s00432-024-05632-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38411731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38411731"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mingjun Wang, Jian Wu, Yufan Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tripartite motif-containing protein 3 on the proliferation and cytokine secretion of rheumatoid arthritis fibroblast-like synoviocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.6164"}], "href": "https://doi.org/10.3892/mmr.2017.6164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28259936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28259936"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jinrong Zhu, Geyan Wu, Zunfu Ke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting TRIM3 deletion-induced tumor-associated lymphangiogenesis prohibits lymphatic metastasis in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0621-5"}], "href": "https://doi.org/10.1038/s41388-018-0621-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30542119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30542119"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mingjun Wang, Jian Wu, Erye Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Forkhead box o3a suppresses lipopolysaccharide-stimulated proliferation and inflammation in fibroblast-like synoviocytes through regulating tripartite motif-containing protein 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28615"}], "href": "https://doi.org/10.1002/jcp.28615"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30980385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30980385"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Wenwen Dong, Bei Luo, Chang Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202181"}], "href": "https://doi.org/10.18632/aging.202181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33253119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33253119"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Cristina Tocchini, Rafal Ciosk "}, {"type": "b", "children": [{"type": "t", "text": "TRIM-NHL proteins in development and disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Semin Cell Dev Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.semcdb.2015.10.017"}], "href": "https://doi.org/10.1016/j.semcdb.2015.10.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26514622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26514622"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yingying Deng, Yuhua Shi, Chenting Wen "}, {"type": "b", "children": [{"type": "t", "text": "TRIM3 Inhibits H"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "O"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "-Induced Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via Ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Eye Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/02713683.2022.2040538"}], "href": "https://doi.org/10.1080/02713683.2022.2040538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35317686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35317686"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Diego Esposito, Jane Dudley-Fraser, Acely Garza-Garcia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-35300-7"}], "href": "https://doi.org/10.1038/s41467-022-35300-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36481767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36481767"}]}]}]}
Synonyms	HAC1, RNF22, BERP, RNF97
Proteins	TRIM3_HUMAN
NCBI Gene ID	10612
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TRIM3 has 5,329 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for TRIM3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TRIM3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TRIM3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TRIM3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TRIM3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIM3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIM3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIM3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TRIM3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIM3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIM3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TRIM3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TRIM3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRIM3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TRIM3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TRIM3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TRIM3 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TRIM3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TRIM3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TRIM3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TRIM3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TRIM3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TRIM3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TRIM3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIM3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TRIM3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TRIM3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TRIM3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TRIM3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TRIM3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TRIM3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TRIM3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TRIM3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TRIM3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TRIM3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRIM3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TRIM3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TRIM3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIM3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.