| Name | TRIM39-RPP21 readthrough |
| Description | This locus represents naturally occurring read-through transcription between the neighboring TRIM39 (tripartite motif-containing 39) and RPP21 (ribonuclease P/MRP 21kDa subunit) genes on chromosome 6. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe studies presented across these abstracts collectively describe a mechanism by which an epitranscriptomic writer—ALKBH8—ensures accurate translation through its action on transfer RNA. ALKBH8 functions as a tRNA methyltransferase that catalyzes the formation of key wobble uridine modifications (such as mcm5U and its derivatives) and, through interactions with accessory factors like TRM112, enables proper tRNA maturation and the specialized decoding required for selenoprotein translation. These modified tRNAs are essential for recoding stop codons and thereby facilitate the synthesis of selenoproteins that mitigate oxidative stress and protect against cellular damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn addition, ALKBH8 activity has been linked to the cellular antioxidant response by promoting the translation of enzymes from the glutathione peroxidase and thioredoxin reductase families. This regulation is critical for maintaining redox balance and cellular homeostasis under both basal conditions and in response to environmental challenges such as oxidative stress and toxic insults."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n\nFurthermore, beyond its core role in tRNA modification, loss of ALKBH8 activity leads to marked cellular reprogramming, including alterations in stress response signaling, mitochondrial metabolism, and senescence pathways. These changes underscore the broader impact of epitranscriptomic modifications on gene expression and organismal resilience, as demonstrated by increased susceptibility to environmental toxins in deficient models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n\nIt is important to note that while your query specifically names TRIM39-RPP21, none of these abstracts describe or discuss this factor. Instead, they focus entirely on the functions and downstream consequences of ALKBH8-mediated tRNA modifications. Further investigation would be required to clarify the role of TRIM39-RPP21 in this context.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lene Songe-Møller, Erwin van den Born, Vibeke Leihne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01602-09"}], "href": "https://doi.org/10.1128/MCB.01602-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20123966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20123966"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Erwin van den Born, Cathrine B Vågbø, Lene Songe-Møller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1173"}], "href": "https://doi.org/10.1038/ncomms1173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21285950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21285950"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lauren Endres, Ulrike Begley, Ryan Clark, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0131335"}], "href": "https://doi.org/10.1371/journal.pone.0131335"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26147969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26147969"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "May Y Lee, Andrea Leonardi, Thomas J Begley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "☆"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Redox Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.redox.2019.101375"}], "href": "https://doi.org/10.1016/j.redox.2019.101375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31765888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31765888"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2020.1750213"}], "href": "https://doi.org/10.1080/15592294.2020.1750213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32303148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32303148"}]}]}]}
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| Synonyms | TRIM39R |
| NCBI Gene ID | 202658 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TRIM39-RPP21 has 721 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 32 datasets.
Click the + buttons to view associations for TRIM39-RPP21 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TRIM39-RPP21 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of TRIM39-RPP21 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of TRIM39-RPP21 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of TRIM39-RPP21 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing TRIM39-RPP21 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with TRIM39-RPP21 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TRIM39-RPP21 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of TRIM39-RPP21 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with TRIM39-RPP21 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TRIM39-RPP21 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with TRIM39-RPP21 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with TRIM39-RPP21 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TRIM39-RPP21 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of TRIM39-RPP21 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with TRIM39-RPP21 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of TRIM39-RPP21 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TRIM39-RPP21 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of TRIM39-RPP21 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of TRIM39-RPP21 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of TRIM39-RPP21 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with TRIM39-RPP21 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of TRIM39-RPP21 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of TRIM39-RPP21 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of TRIM39-RPP21 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TRIM39-RPP21 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of TRIM39-RPP21 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TRIM39-RPP21 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TRIM39-RPP21 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of TRIM39-RPP21 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of TRIM39-RPP21 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with TRIM39-RPP21 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TRIM39-RPP21 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
