{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTripartite motif 47 (TRIM47) has emerged as an important oncogenic factor whose overexpression and activity have been associated with poor clinical outcomes in a variety of human cancers. In prostate cancer, preliminary investigations have assessed TRIM47 expression as a potential prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In non‐small cell lung carcinoma, TRIM47 is markedly upregulated and its high expression correlates with enhanced cell proliferation, G1‐phase progression, migration, invasion, and tumorigenicity through mechanisms that include suppression of p53 signaling and activation of NF‑κB pathways, thereby promoting epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in colorectal cancer, significantly elevated TRIM47 mRNA and protein levels are observed in tumor tissues and are associated with advanced tumor stage and poor patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In glioma, TRIM47 has been shown to drive cell proliferation, migration, and invasion via activation of the Wnt/β‑catenin pathway, as its knockdown leads to a suppression of these tumorigenic properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In gastric cancer, elevated TRIM47 expression not only correlates with tumor progression and advanced staging but is also linked to reduced overall and disease‐free survival, and bioinformatic analyses implicate its involvement in multiple signaling networks including NF‑κB, epithelial–mesenchymal transition, hypoxia, and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Investigations in breast cancer have further revealed that TRIM47 can promote endocrine therapy resistance by facilitating cell proliferation through enhancement of NF‑κB signaling, in part by stabilizing NF‑κB–activating kinases PKC‑ε and PKD3 via lysine 27–linked polyubiquitination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, TRIM47 contributes to glioma angiogenesis by downregulating the expression of SMAD4, thereby promoting vascularization and further supporting tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, emerging studies in ovarian cancer suggest an oncogenic role for TRIM47, with its dysregulated expression contributing to tumor progression, while additional reports in prostate tissues reinforce its relevance across multiple cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tetsuya Fujimura, Satoshi Inoue, Tomohiko Urano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased Expression of Tripartite Motif (TRIM) 47 Is a Negative Prognostic Predictor in Human Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genitourin Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clgc.2016.01.011"}], "href": "https://doi.org/10.1016/j.clgc.2016.01.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26873435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26873435"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yudong Han, Haiying Tian, Pei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM47 overexpression is a poor prognostic factor and contributes to carcinogenesis in non-small cell lung carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15188"}], "href": "https://doi.org/10.18632/oncotarget.15188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28186994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28186994"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qian Liang, Chaotao Tang, Mingyu Tang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of TRIM47 inhibits glioma cell proliferation, migration and invasion through the inactivation of Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Probes (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcp.2020.101623"}], "href": "https://doi.org/10.1016/j.mcp.2020.101623"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32603762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32603762"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "YuJian Xia, ZheWei Wei, WeiBin Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trim47 overexpression correlates with poor prognosis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2020_200708N706"}], "href": "https://doi.org/10.4149/neo_2020_200708N706"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33350849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33350849"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kotaro Azuma, Kazuhiro Ikeda, Takashi Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM47 activates NF-κB signaling via PKC-ε/PKD3 stabilization and contributes to endocrine therapy resistance in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2100784118"}], "href": "https://doi.org/10.1073/pnas.2100784118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34433666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34433666"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zifan Wang, Zhiqiang Li, Chuangchuang Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM47 promotes glioma angiogenesis by suppressing Smad4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "In Vitro Cell Dev Biol Anim (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11626-022-00722-6"}], "href": "https://doi.org/10.1007/s11626-022-00722-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36203070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36203070"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xi Wang, Yu Fu, Yanyan Xing "}, {"type": "b", "children": [{"type": "t", "text": "TRIM47 promotes ovarian cancer cell proliferation, migration, and invasion by activating STAT3 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clinics (Sao Paulo) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinsp.2022.100122"}], "href": "https://doi.org/10.1016/j.clinsp.2022.100122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36288633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36288633"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Bin Ji, Lijuan Liu, Yongping Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated Tripartite Motif 47 Could Facilitate Glioma Cell Proliferation and Metastasis as a Tumorigenesis Promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/5594973"}], "href": "https://doi.org/10.1155/2021/5594973"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33833824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33833824"}]}]}]}