TRIM8 Gene

HGNC Family	Zinc fingers, Tripartite motif-containing (TRIM)
Name	tripartite motif containing 8
Description	This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRIM8 exerts critical regulatory roles in inflammation and innate immunity. It positively modulates TNFα‐ and IL‐1β–induced NF‐κB activation by promoting K63-linked polyubiquitination of key mediators such as TAK1, while it also attenuates the suppressive actions of proteins like PIAS3. In addition, TRIM8 interacts with SOCS-1, reducing its stability and thereby fine-tuning cytokine signaling. Remarkably, in plasmacytoid dendritic cells TRIM8 protects phosphorylated IRF7 from proteasomal degradation, establishing an important mechanism for robust type I interferon production."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer and cellular stress contexts, TRIM8 plays a multifaceted role in controlling cell proliferation and survival. It stabilizes p53 by impairing its interaction with MDM2 and thereby promotes the transcription of cell cycle arrest and DNA repair genes. Concurrently, TRIM8 enhances STAT3 signaling by counteracting the inhibitory actions of PIAS3 and by modulating Hsp90β-mediated nuclear translocation of phosphorylated STAT3. Through its E3 ubiquitin ligase activity, TRIM8 also targets fusion oncoproteins such as EWS/FLI in Ewing sarcoma, while its tumor suppressor functions have been exemplified in laryngeal squamous cell carcinoma. In gliomas and glioblastoma, TRIM8 assumes a “double-edged sword” role by engaging in pathways that regulate stemness, mitotic spindle dynamics, and chromosomal stability, as well as by interacting with other TRIM family members such as TRIM21 to maintain cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in oncogenesis and immune regulation, TRIM8 is pivotal in controlling cellular responses during development and stress. De novo truncating mutations in TRIM8 have been linked to neurodevelopmental disorders and epileptic encephalopathy, often coupled with renal manifestations, underscoring its importance in brain and kidney function. Moreover, TRIM8 modulates autophagy during the DNA damage response, contributing to cell survival under genotoxic stress, and its suppression has been shown to alleviate inflammatory responses in conditions such as acute lung injury and osteoarthritis. In hepatocellular carcinoma and ovarian cancer, TRIM8 promotes tumor progression by facilitating the ubiquitination and degradation of key transcription factors, highlighting its context-dependent oncogenic potential."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qi Li, Jie Yan, Ai-Ping Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1110946108"}], "href": "https://doi.org/10.1073/pnas.1110946108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22084099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22084099"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dhanendra Tomar, Lakshmi Sripada, Paresh Prajapati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-κB pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0048662"}], "href": "https://doi.org/10.1371/journal.pone.0048662"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23152791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23152791"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elena Toniato, X Peter Chen, Julie Losman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8/GERP RING finger protein interacts with SOCS-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M205900200"}], "href": "https://doi.org/10.1074/jbc.M205900200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12163497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12163497"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "E Toniato, V Flati, E Laglia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic organization and cytokine-mediated inducibility of the human TRIM-8/Gerp gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Immunopathol Pharmacol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/03946320040170S212"}], "href": "https://doi.org/10.1177/03946320040170S212"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15345195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15345195"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ghizlane Maarifi, Nikaïa Smith, Sarah Maillet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.aax3511"}], "href": "https://doi.org/10.1126/sciadv.aax3511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31799391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31799391"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Francesco Carinci, Diego Arcelli, Lorenzo Lo Muzio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.trsl.2007.03.011"}], "href": "https://doi.org/10.1016/j.trsl.2007.03.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17900511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17900511"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fumihiko Okumura, Yui Matsunaga, Yuta Katayama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8 modulates STAT3 activity through negative regulation of PIAS3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.068981"}], "href": "https://doi.org/10.1242/jcs.068981"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20516148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20516148"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Fumihiko Okumura, Akiko J Okumura, Masaki Matsumoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2011.05.013"}], "href": "https://doi.org/10.1016/j.bbamcr.2011.05.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21689689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21689689"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mariano Francesco Caratozzolo, Lucia Micale, Maria Giuseppina Turturo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8 modulates p53 activity to dictate cell cycle arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.11.3.19008"}], "href": "https://doi.org/10.4161/cc.11.3.19008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22262183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22262183"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Mariano Francesco Caratozzolo, Alessio Valletti, Margherita Gigante, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2081"}], "href": "https://doi.org/10.18632/oncotarget.2081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25277184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25277184"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lucia Micale, Carmela Fusco, Andrea Fontana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-015-1449-9"}], "href": "https://doi.org/10.1186/s12885-015-1449-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26077989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26077989"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Changming Zhang, Subhas Mukherjee, Carol Tucker-Burden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12034"}], "href": "https://doi.org/10.1002/1878-0261.12034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28100038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28100038"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Santina Venuto, Laura Monteonofrio, Flora Cozzolino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2019.12.042"}], "href": "https://doi.org/10.1016/j.canlet.2019.12.042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31904480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31904480"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Bo Kyung A Seong, Neekesh V Dharia, Shan Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2021.07.003"}], "href": "https://doi.org/10.1016/j.ccell.2021.07.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34329586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34329586"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hamed Hosseinalizadeh, Omid Mohamadzadeh, Mohammad Saeed Kahrizi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-023-00418-z"}], "href": "https://doi.org/10.1186/s11658-023-00418-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36690946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36690946"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Lin Wang, Hui Li, Aixue Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-023-02879-0"}], "href": "https://doi.org/10.1038/s41388-023-02879-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37914816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37914816"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yasunari Sakai, Ryoko Fukai, Yuki Matsushita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De Novo Truncating Mutation of TRIM8 Causes Early-Onset Epileptic Encephalopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ahg.12157"}], "href": "https://doi.org/10.1111/ahg.12157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27346735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27346735"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Mirna Assoum, Matthew A Lines, Orly Elpeleg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Further delineation of the clinical spectrum of de novo TRIM8 truncating mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.40357"}], "href": "https://doi.org/10.1002/ajmg.a.40357"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30244534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30244534"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Patricia L Weng, Amar J Majmundar, Kamal Khan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2021.01.008"}], "href": "https://doi.org/10.1016/j.ajhg.2021.01.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33508234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33508234"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Chaodong Ding, Chunling Zhang, Richard Kopp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor POU3F2 regulates TRIM8 expression contributing to cellular functions implicated in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41380-020-00877-2"}], "href": "https://doi.org/10.1038/s41380-020-00877-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32929213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32929213"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Milton Roy, Dhanendra Tomar, Kritarth Singh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8 regulated autophagy modulates the level of cleaved Caspase-3 subunit to inhibit genotoxic stress induced cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2018.04.003"}], "href": "https://doi.org/10.1016/j.cellsig.2018.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29678622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29678622"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Li Xiaoli, Zou Wujun, Liu Jing "}, {"type": "b", "children": [{"type": "t", "text": "Blocking of tripartite motif 8 protects against lipopolysaccharide (LPS)-induced acute lung injury by regulating AMPKα activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.11.072"}], "href": "https://doi.org/10.1016/j.bbrc.2018.11.072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30527811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30527811"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ruoxi Liu, Hao Wu, Huanjin Song "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of TRIM8 Attenuates IL-1β-induced Inflammatory Response in Osteoarthritis Chondrocytes Through the Inactivation of NF-κB Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Transplant (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0963689720943604"}], "href": "https://doi.org/10.1177/0963689720943604"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32757662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32757662"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yu Peng, Hui Qian, Wen-Ping Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-024-06819-y"}], "href": "https://doi.org/10.1038/s41419-024-06819-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38879600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38879600"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Fei Wu, Jiaqi Xu, Xin Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM8 promotes ovarian cancer proliferation and migration by targeting VDAC2 for ubiquitination and degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.7396"}], "href": "https://doi.org/10.1002/cam4.7396"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38881325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38881325"}]}]}]}
Synonyms	GERP, RNF27
Proteins	TRIM8_HUMAN
NCBI Gene ID	81603
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TRIM8 has 7,566 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for TRIM8 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TRIM8 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM8 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM8 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TRIM8 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TRIM8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TRIM8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIM8 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIM8 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIM8 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIM8 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TRIM8 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIM8 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIM8 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TRIM8 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TRIM8 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRIM8 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TRIM8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TRIM8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TRIM8 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TRIM8 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TRIM8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TRIM8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TRIM8 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TRIM8 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TRIM8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TRIM8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIM8 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TRIM8 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with TRIM8 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TRIM8 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TRIM8 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TRIM8 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TRIM8 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TRIM8 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TRIM8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TRIM8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TRIM8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TRIM8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TRIM8 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRIM8 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TRIM8 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.