TRIP11 Gene

Name	thyroid hormone receptor interactor 11
Description	This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRIP11 encodes the Golgi microtubule‐associated protein 210 (GMAP‑210), a long coiled‑coil golgin that plays a central role in maintaining Golgi architecture by tethering membranes with differing curvature. GMAP‑210 uses an amino‑terminal amphipathic lipid‑packing sensor (ALPS) motif to preferentially bind to highly curved transport vesicles and, in conjunction with interacting partners such as Arf1 and Rab2, mediates their association with the cis‑Golgi membranes. Overexpression or depletion of GMAP‑210 perturbs vesicular trafficking, leading to abnormal Golgi fragmentation, defective anterograde and retrograde transport between the endoplasmic reticulum and the Golgi, and disruption of microtubule interactions that are essential for Golgi ribbon integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn vivo, proper function of TRIP11/GMAP‑210 is indispensable for efficient secretory trafficking, and its disruption underlies a spectrum of skeletal dysplasias. Null alleles impair Golgi structure and secretory processing, causing severe phenotypes such as achondrogenesis type 1A, whereas hypomorphic mutations lead to milder conditions like odontochondrodysplasia. In addition to its Golgi‑associated functions, TRIP11 can undergo triiodothyronine‑dependent phosphorylation that regulates its nuclear localization, suggesting a dual role in transcriptional coactivation linked to thyroid hormone signaling. These multifaceted activities underscore how altered TRIP11 function impinges on both intracellular trafficking and the developmental pathways essential for skeletal formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guillaume Drin, Vincent Morello, Jean-François Casella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Asymmetric tethering of flat and curved lipid membranes by a golgin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1155821"}], "href": "https://doi.org/10.1126/science.1155821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18451304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18451304"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maud Magdeleine, Romain Gautier, Pierre Gounon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A filter at the entrance of the Golgi that selects vesicles according to size and bulk lipid composition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.16988"}], "href": "https://doi.org/10.7554/eLife.16988"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27458799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27458799"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Karin Pernet-Gallay, Claude Antony, Ludger Johannes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1034/j.1600-0854.2002.31107.x"}], "href": "https://doi.org/10.1034/j.1600-0854.2002.31107.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12383348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12383348"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Keisuke Sato, Peristera Roboti, Alexander A Mironov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coupling of vesicle tethering and Rab binding is required for in vivo functionality of the golgin GMAP-210."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E14-10-1450"}], "href": "https://doi.org/10.1091/mbc.E14-10-1450"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25473115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25473115"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Peristera Roboti, Keisuke Sato, Martin Lowe "}, {"type": "b", "children": [{"type": "t", "text": "The golgin GMAP-210 is required for efficient membrane trafficking in the early secretory pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.166710"}], "href": "https://doi.org/10.1242/jcs.166710"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25717001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25717001"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jesus Cardenas, Sabrina Rivero, Bruno Goud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1741-7007-7-56"}], "href": "https://doi.org/10.1186/1741-7007-7-56"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19715559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19715559"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Patrick Smits, Andrew D Bolton, Vincent Funari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa0900158"}], "href": "https://doi.org/10.1056/NEJMoa0900158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20089971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20089971"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Cristina T N Medina, Renata Sandoval, Gabriela Oliveira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathogenic variants in the TRIP11 gene cause a skeletal dysplasia spectrum from odontochondrodysplasia to achondrogenesis 1A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.61460"}], "href": "https://doi.org/10.1002/ajmg.a.61460"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31903676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31903676"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Piotr Popławski, Agnieszka Piekiełko-Witkowska, Alicja Nauman "}, {"type": "b", "children": [{"type": "t", "text": "The significance of TRIP11 and T3 signalling pathway in renal cancer progression and survival of patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endokrynol Pol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5603/EP.a2017.0052"}], "href": "https://doi.org/10.5603/EP.a2017.0052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29022645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29022645"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Anika Wehrle, Tomasz M Witkos, Judith C Schneider, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A common pathomechanism in GMAP-210- and LBR-related diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.121150"}], "href": "https://doi.org/10.1172/jci.insight.121150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30518689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30518689"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mariana Del Pino, Maria José Sanchez-Soler, Manuel Parrón-Pajares, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Description of four patients with TRIP11 variants expand the clinical spectrum of odontochondroplasia (ODCD) and demonstrate the existence of common variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2021.104198"}], "href": "https://doi.org/10.1016/j.ejmg.2021.104198"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33746040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33746040"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Priyanka Upadhyai, Periyasamy Radhakrishnan, Vishal S Guleria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biallelic deep intronic variant c.5457+81T>A in TRIP11 causes loss of function and results in achondrogenesis 1A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.24235"}], "href": "https://doi.org/10.1002/humu.24235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34057271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34057271"}]}]}]}
Synonyms	ACG1A, GMAP210, TRIP230, GMAP-210, TRIP-11, CEV14
Proteins	TRIPB_HUMAN
NCBI Gene ID	9321
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TRIP11 has 6,460 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 135 datasets.

Click the + buttons to view associations for TRIP11 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TRIP11 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TRIP11 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIP11 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIP11 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TRIP11 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TRIP11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TRIP11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRIP11 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIP11 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIP11 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRIP11 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIP11 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TRIP11 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with TRIP11 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TRIP11 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TRIP11 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRIP11 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TRIP11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TRIP11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TRIP11 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TRIP11 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TRIP11 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TRIP11 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TRIP11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TRIP11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TRIP11 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TRIP11 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TRIP11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TRIP11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRIP11 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TRIP11 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TRIP11 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TRIP11 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TRIP11 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TRIP11 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TRIP11 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TRIP11 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TRIP11 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TRIP11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TRIP11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TRIP11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.