TRPV2 Gene

HGNC Family	Ion channels, Ankyrin repeat domain containing (ANKRD)
Name	transient receptor potential cation channel, subfamily V, member 2
Description	This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTRPV2 is a non‐selective cation channel whose dysregulated function is implicated in a variety of cancers. In prostate cancer, for example, its up‐regulation is linked to castration‐resistant, aggressive disease through promotion of cell migration and invasive enzyme expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, adrenomedullin–TRPV2 signalling promotes migration and invasion in prostate and urothelial cancers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", while studies in glioma cells indicate that TRPV2 can negatively regulate cell survival and proliferation by modulating pro‐apoptotic and cell cycle regulators in an ERK‐dependent manner."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In hepatocellular carcinoma, TRPV2 expression is increased in cirrhotic livers and is associated with portal vein invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and its heightened mRNA levels have been correlated with advanced stage and metastasis in esophageal squamous cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn immune-related contexts TRPV2 plays key roles in orchestrating Ca²⁺-dependent responses. In mast cells, TRPV2 is activated by multiple physical stimuli—including mechanical stress, high temperature, and red laser light—leading to pronounced degranulation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while related studies document its coupling to Ca²⁺ flux and proinflammatory degranulation in response to thermal, osmotic, and pressure stimuli."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In primary human macrophages, recruitment of TRPV2 to the plasma membrane is essential for Pseudomonas aeruginosa–induced Ca²⁺ influx and efficient phagocytosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "; moreover, its activity can be directly modulated by redox‐induced oxidation in a methionine‐dependent manner."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic studies have provided structural insight and revealed key aspects of TRPV2 regulation. For instance, recombinant expression of TRPV2 has been linked to cytotoxicity that can be modulated via phosphatidylinositol kinase signalling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and high-resolution crystal structures of its ankyrin repeat domain disclose novel features compared with canonical ARDs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Furthermore, functional analyses in F-11 cells reveal that its Ca²⁺-dependent desensitization is governed by depletion of membrane PIP₂"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", and rational engineering has yielded a TRPV2 mutant (TRPV2_Quad) that gains high-affinity binding of vanilloids—offering a model for ligand-induced gating similar to TRPV1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTRPV2 is broadly expressed in several normal tissues. It is present in peripheral blood cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", and immunohistochemical studies document its localization in human skin sensory nerve fibers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "as well as in corneal epithelial cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "and other nerve fibers in the skin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " In addition, in neurons, TRPV2 is up-regulated by nerve growth factor via ERK-dependent phosphorylation, thereby promoting neurite outgrowth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in normal physiology, modulation of TRPV2 has therapeutic potential. For example, TRPV2 agonists have been shown to reduce the invasiveness of fibroblast-like synoviocytes in arthritis, suggesting a novel anti-inflammatory strategy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michaël Monet, V'yacheslav Lehen'kyi, Florian Gackiere, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-2205"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-2205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20103638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20103638"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Agathe Oulidi, Alexandre Bokhobza, Dimitra Gkika, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0064885"}], "href": "https://doi.org/10.1371/journal.pone.0064885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23741410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23741410"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Massimo Nabissi, Maria Beatrice Morelli, Consuelo Amantini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgq019"}], "href": "https://doi.org/10.1093/carcin/bgq019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20093382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20093382"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guoxing Liu, Chengzhi Xie, Fadi Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet Cytogenet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergencyto.2009.08.007"}], "href": "https://doi.org/10.1016/j.cancergencyto.2009.08.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20113837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20113837"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sara Caprodossi, Roberta Lucciarini, Consuelo Amantini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transient receptor potential vanilloid type 2 (TRPV2) expression in normal urothelium and in urothelial carcinoma of human bladder: correlation with the pathologic stage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Urol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.eururo.2007.10.016"}], "href": "https://doi.org/10.1016/j.eururo.2007.10.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17977643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17977643"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kun Zhou, Shui-Shen Zhang, Yan Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of transient receptor potential vanilloid 2 is associated with poor prognosis in patients with esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0017-5"}], "href": "https://doi.org/10.1007/s12032-014-0017-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24878697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24878697"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "D Zhang, A Spielmann, L Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mast-cell degranulation induced by physical stimuli involves the activation of transient-receptor-potential channel TRPV2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.33549/physiolres.932053"}], "href": "https://doi.org/10.33549/physiolres.932053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21574765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21574765"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Alexander J Stokes, Lori M N Shimoda, Murielle Koblan-Huberson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20032082"}], "href": "https://doi.org/10.1084/jem.20032082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15249591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15249591"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Manuella Lévêque, Aubin Penna, Sophie Le Trionnaire, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phagocytosis depends on TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-22558-5"}], "href": "https://doi.org/10.1038/s41598-018-22558-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29523858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29523858"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tabea C Fricke, Frank Echtermeyer, Johannes Zielke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1904332116"}], "href": "https://doi.org/10.1073/pnas.1904332116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31719194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31719194"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Aubin Penna, Véronique Juvin, Jean Chemin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Calcium (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ceca.2006.01.009"}], "href": "https://doi.org/10.1016/j.ceca.2006.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16533525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16533525"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Clare J McCleverty, Eric Koesema, Ardem Patapoutian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of the human TRPV2 channel ankyrin repeat domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Sci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1110/ps.062357206"}], "href": "https://doi.org/10.1110/ps.062357206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16882997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16882997"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jose Mercado, Ariela Gordon-Shaag, William N Zagotta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ca2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2108-10.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.2108-10.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20926660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20926660"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Cassandra Im Saunders, Dale A Kunde, Amanda Crawford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2006.04.027"}], "href": "https://doi.org/10.1016/j.molimm.2006.04.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16777226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16777226"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Giacomo Spinsanti, Raffaella Zannolli, Cristina Panti, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2009.05.052"}], "href": "https://doi.org/10.1016/j.neuroscience.2009.05.052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19482060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19482060"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Matthew R Cohen, William M Johnson, Jennifer M Pilat, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "TRPV2-induced Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Commun Signal (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12964-018-0280-8"}], "href": "https://doi.org/10.1186/s12964-018-0280-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30326911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30326911"}]}]}]}
Synonyms	VRL1, VRL, VRL-1
Proteins	TRPV2_HUMAN
NCBI Gene ID	51393
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TRPV2 has 6,704 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 118 datasets.

Click the + buttons to view associations for TRPV2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TRPV2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TRPV2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRPV2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRPV2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TRPV2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TRPV2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TRPV2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TRPV2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TRPV2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRPV2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TRPV2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TRPV2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRPV2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TRPV2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TRPV2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TRPV2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRPV2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TRPV2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TRPV2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TRPV2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TRPV2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TRPV2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TRPV2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TRPV2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TRPV2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TRPV2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TRPV2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TRPV2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TRPV2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TRPV2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TRPV2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TRPV2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TRPV2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TRPV2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TRPV2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TRPV2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TRPV2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of TRPV2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with TRPV2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing TRPV2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of TRPV2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.