TSC22D1 Gene

Name	TSC22 domain family, member 1
Description	This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTSC22D1, also known as TSC‐22, is a leucine zipper transcription factor originally isolated as a TGF‑β–inducible gene and further shown to be upregulated by diverse signals including PPARγ. Its activation leads to growth inhibition and differentiation via transcriptional regulation – for example, by upregulating the cell cycle inhibitor p21 and modulating crucial transcription factors such as Smad3/4 and p53. In addition, post‑transcriptional mechanisms, including mRNA stabilization, and the generation of distinct isoforms have been documented, indicating that TSC22D1 may fine‑tune TGF‑β and PKC pathway responses in a context‑dependent manner."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various neoplastic contexts TSC22D1 acts as a tumor suppressor. Its expression is enriched in differentiated cell populations of tissues such as the prostate, colon, and salivary gland, while its loss or downregulation is associated with malignant transformation. In cervical cancer cells, for instance, TSC22D1 interacts with p53 to protect it from poly‑ubiquitination and degradation, and in ovarian carcinoma its binding to fortilin influences apoptotic outcomes. Moreover, enforced expression of TSC22D1 in leukemia models promotes differentiation and growth arrest, and isoform‐specific regulation – with the short isoform being critical for oncogene‑induced senescence – further underscores its antitumorigenic functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in tumor suppression and differentiation, TSC22D1 is also implicated in broader physiological and pathological processes. Genetic variants of the TSC22D1 gene have been associated with diabetic microvascular complications, such as diabetic nephropathy, suggesting a link between TSC22D1 function and metabolic regulation. In vascular smooth muscle cells, TSC22D1 enhances transcription of protective factors like C‑type natriuretic peptide in response to TGF‑β and PDGF‑BB, highlighting its role as an important mediator of vascular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rajnish A Gupta, Pasha Sarraf, Jeffrey A Brockman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208076200"}], "href": "https://doi.org/10.1074/jbc.M208076200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12468551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12468551"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "So-Jung Choi, Jae-Hoon Moon, Young-Wook Ahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-005-3456-7"}], "href": "https://doi.org/10.1007/s11010-005-3456-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15881652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15881652"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Silvia Gluderer, Erich Brunner, Markus Germann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/jbiol216"}], "href": "https://doi.org/10.1186/jbiol216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20149264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20149264"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Cornelia Hömig-Hölzel, Remco van Doorn, Celia Vogel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.95"}], "href": "https://doi.org/10.1038/emboj.2011.95"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21448135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21448135"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Daisuke Uchida, Fumie Omotehara, Koh-ichi Nakashiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)00854-4"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "00854-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12767908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12767908"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hyesun Ahn, Taehee Han "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of TGF-β signaling by PKC depends on Tsc-22 inducibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-011-1042-8"}], "href": "https://doi.org/10.1007/s11010-011-1042-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21881999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21881999"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Cyrill A Rentsch, Marco G Cecchini, Ruth Schwaninger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.21449"}], "href": "https://doi.org/10.1002/ijc.21449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16106424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16106424"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Cheol-Hee Yoon, Seung Bae Rho, Seong-Tae Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crucial role of TSC-22 in preventing the proteasomal degradation of p53 in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0042006"}], "href": "https://doi.org/10.1371/journal.pone.0042006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22870275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22870275"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jeong Heon Lee, Seung Bae Rho, Sang-Yoon Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between fortilin and transforming growth factor-beta stimulated clone-22 (TSC-22) prevents apoptosis via the destabilization of TSC-22."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2008.01.066"}], "href": "https://doi.org/10.1016/j.febslet.2008.01.066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18325344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18325344"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Y Lu, J Kitaura, T Oki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.leu.2404883"}], "href": "https://doi.org/10.1038/sj.leu.2404883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17690703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17690703"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Satoshi Hino, Hitoshi Kawamata, Fumie Omotehara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11836610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11836610"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yutaka Doi, Hitoshi Kawamata, Yuko Ono, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: implications for tumor cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18288391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18288391"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ryouta Kamimura, Daisuke Uchida, Shin-Ichiro Kanno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Binding Proteins for TSC22D1 Family Proteins Using Mass Spectrometry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms222010913"}], "href": "https://doi.org/10.3390/ijms222010913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34681573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34681573"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shaolan Qin, Yong Zhou, Jianjun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low levels of TSC22 enhance tumorigenesis by inducing cell proliferation in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.02.177"}], "href": "https://doi.org/10.1016/j.bbrc.2018.02.177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29481799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29481799"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Monika Buraczynska, Iwona Baranowicz-Gaszczyk, Ewa Borowicz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TGF-beta1 and TSC-22 gene polymorphisms and susceptibility to microvascular complications in type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nephron Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000104874"}], "href": "https://doi.org/10.1159/000104874"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17622752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17622752"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Maria C Mendonça, Nancy Koles, Sonia Q Doi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transforming growth factor-beta1 regulation of C-type natriuretic peptide expression in human vascular smooth muscle cells: dependence on TSC22D1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.00656.2010"}], "href": "https://doi.org/10.1152/ajpheart.00656.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20802130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20802130"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Fumiaki Sugawara, Yuichiro Yamada, Rie Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes Res Clin Pract (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0168-8227(03)00038-x"}], "href": "https://doi.org/10.1016/s0168-8227(03"}, {"type": "t", "text": "00038-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12757981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12757981"}]}]}]}
Synonyms	TSC22, PTG-2, TGFB1I4
Proteins	T22D1_HUMAN
NCBI Gene ID	8848
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TSC22D1 has 11,863 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for TSC22D1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TSC22D1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TSC22D1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TSC22D1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TSC22D1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TSC22D1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TSC22D1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TSC22D1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TSC22D1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TSC22D1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TSC22D1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TSC22D1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TSC22D1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TSC22D1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TSC22D1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TSC22D1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TSC22D1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TSC22D1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TSC22D1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TSC22D1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TSC22D1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TSC22D1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TSC22D1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TSC22D1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TSC22D1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TSC22D1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TSC22D1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TSC22D1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TSC22D1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TSC22D1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TSC22D1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TSC22D1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TSC22D1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TSC22D1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TSC22D1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TSC22D1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TSC22D1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TSC22D1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TSC22D1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TSC22D1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with TSC22D1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with TSC22D1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.