{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTSC22D3, better known as the glucocorticoid‐induced leucine zipper (GILZ), is a pivotal mediator of glucocorticoid signaling in immune cells. It is rapidly induced in T lymphocytes, dendritic cells, macrophages, and endothelial cells, where it counteracts pro‐inflammatory signals by inhibiting key transcription factors (e.g., NF‑κB, AP‑1) and modulating mitogen‐activated protein kinase (MAPK) activity. By doing so, GILZ diminishes pro‐inflammatory cytokine production and promotes the differentiation of regulatory T cells, ultimately contributing to endotoxin tolerance and, in stress conditions, even dampening anticancer immunosurveillance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its immunomodulatory functions, TSC22D3 exerts significant control over cellular proliferation, apoptosis, and oncogenic signaling. In epithelial cells, such as those in the kidney, discrete GILZ isoforms fine‑tune sodium transport via inhibition of ERK signaling and stabilization of complexes that regulate epithelial sodium channel (ENaC) expression. In various cancers, including multiple myeloma and ovarian carcinoma, GILZ influences cell survival and therapeutic response by modulating pathways such as mTORC2/AKT and p53, and by protecting lymphocytes from cytokine withdrawal–induced apoptosis via suppression of Forkhead box transcriptional activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to regulating inflammation and cell survival, TSC22D3 plays an important role in broader physiological and stress‐related processes. Altered GILZ expression has been observed in neuropsychiatric conditions (with correlations to posttraumatic stress disorder and reduced hippocampal volume in depression), vascular inflammation, and adipose tissue dysfunction, thereby impacting blood pressure regulation and adipokine secretion. Furthermore, emerging evidence indicates that GILZ can protect against endoplasmic reticulum stress and is essential for proper spermatogenesis, underscoring its multifaceted role in maintaining cellular and systemic homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "33"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dominique Berrebi, Stefano Bruscoli, Nicolas Cohen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-02-0538"}], "href": "https://doi.org/10.1182/blood-2002-02-0538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12393603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12393603"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marie-Liesse Asselin-Labat, Muriel David, Armelle Biola-Vidamment, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2003-12-4295"}], "href": "https://doi.org/10.1182/blood-2003-12-4295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15031210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15031210"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marie-Liesse Asselin-Labat, Armelle Biola-Vidamment, Stéphane Kerbrat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FoxO3 mediates antagonistic effects of glucocorticoids and interleukin-2 on glucocorticoid-induced leucine zipper expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2004-0206"}], "href": "https://doi.org/10.1210/me.2004-0206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15705665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15705665"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Haifa Hamdi, Véronique Godot, Marie-Christine Maillot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2006-10-052506"}], "href": "https://doi.org/10.1182/blood-2006-10-052506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17356131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17356131"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Elaine Beaulieu, Eric F Morand "}, {"type": "b", "children": [{"type": "t", "text": "Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Rheumatol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nrrheum.2011.59"}], "href": "https://doi.org/10.1038/nrrheum.2011.59"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21556028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21556028"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Saartje Hontelez, Nina Karthaus, Maaike W Looman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1201776"}], "href": "https://doi.org/10.4049/jimmunol.1201776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23440419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23440419"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Qiang Cheng, Huapeng Fan, Devi Ngo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GILZ overexpression inhibits endothelial cell adhesive function through regulation of NF-κB and MAPK activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1202662"}], "href": "https://doi.org/10.4049/jimmunol.1202662"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23729444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23729444"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jeffrey S Futterleib, Hao Feng, Robert E Tigelaar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of GILZ gene by photoactivated 8-methoxypsoralen: potential role of immunoregulatory dendritic cells in extracorporeal photochemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transfus Apher Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.transci.2013.10.003"}], "href": "https://doi.org/10.1016/j.transci.2013.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24215840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24215840"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jessica Hoppstädter, Sonja M Kessler, Stefano Bruscoli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoid-induced leucine zipper: a critical factor in macrophage endotoxin tolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1403207"}], "href": "https://doi.org/10.4049/jimmunol.1403207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25964494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25964494"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sarah A Jones, Andrew E J Toh, Dragana Odobasic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/annrheumdis-2015-207744"}], "href": "https://doi.org/10.1136/annrheumdis-2015-207744"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26612340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26612340"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Saeed Mohammadi, Mohammad Reza Ebadpour, Sima Sedighi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoid-induced leucine zipper expression is associated with response to treatment and immunoregulation in systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Rheumatol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10067-017-3711-9"}], "href": "https://doi.org/10.1007/s10067-017-3711-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28601944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28601944"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jessica Hoppstädter, Britta Diesel, Rebecca Linnenberger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amplified Host Defense by Toll-Like Receptor-Mediated Downregulation of the Glucocorticoid-Induced Leucine Zipper (GILZ) in Macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2018.03111"}], "href": "https://doi.org/10.3389/fimmu.2018.03111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30723476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30723476"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lorenza Cannarile, Domenico V Delfino, Sabrina Adorisio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Implicating the Role of GILZ in Glucocorticoid Modulation of T-Cell Activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2019.01823"}], "href": "https://doi.org/10.3389/fimmu.2019.01823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31440237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31440237"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Heng Yang, Lin Xia, Jian Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41591-019-0566-4"}], "href": "https://doi.org/10.1038/s41591-019-0566-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31501614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31501614"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Joanne M Moreau, Kimberly D Dyer, Cynthia A Bonville, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Antiviral Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0166-3542(03)00111-6"}], "href": "https://doi.org/10.1016/s0166-3542(03"}, {"type": "t", "text": "00111-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12927308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12927308"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Rama Soundararajan, Ting Ting Zhang, Jian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M508658200"}], "href": "https://doi.org/10.1074/jbc.M508658200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16216878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16216878"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Rama Soundararajan, Jian Wang, Daniël Melters, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential activities of glucocorticoid-induced leucine zipper protein isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M707287200"}], "href": "https://doi.org/10.1074/jbc.M707287200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17956870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17956870"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Rama Soundararajan, Daniël Melters, I-Chia Shih, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial sodium channel regulated by differential composition of a signaling complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0809892106"}], "href": "https://doi.org/10.1073/pnas.0809892106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19380724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19380724"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Tove Lekva, Jens Bollerslev, Cybéle Kristo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The glucocorticoid-induced leucine zipper gene (GILZ) expression decreases after successful treatment of patients with endogenous Cushing's syndrome and may play a role in glucocorticoid-induced osteoporosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2009-0595"}], "href": "https://doi.org/10.1210/jc.2009-0595"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19875485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19875485"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Perle Latré de Laté, Aurélie Pépin, Hind Assaf-Vandecasteele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoid-induced leucine zipper (GILZ) promotes the nuclear exclusion of FOXO3 in a Crm1-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.068346"}], "href": "https://doi.org/10.1074/jbc.M109.068346"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20018851"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20018851"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Rama Soundararajan, Jian Wang, Daniël Melters, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.161133"}], "href": "https://doi.org/10.1074/jbc.M110.161133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20947508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20947508"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "E Ayroldi, M G Petrillo, A Bastianelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2014.129"}], "href": "https://doi.org/10.1038/cdd.2014.129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25168242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25168242"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Marie-Alix Espinasse, Aurélie Pépin, Pauline Virault-Rocroy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoid-Induced Leucine Zipper Is Expressed in Human Neutrophils and Promotes Apoptosis through Mcl-1 Down-Regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Innate Immun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000439052"}], "href": "https://doi.org/10.1159/000439052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26384220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26384220"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Mirjam van Zuiden, Elbert Geuze, Hanneke L D M Willemen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2011.10.026"}], "href": "https://doi.org/10.1016/j.biopsych.2011.10.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22137507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22137507"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Jessica Hoppstädter, Britta Diesel, Lisa K Eifler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like receptor activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.201142081"}], "href": "https://doi.org/10.1002/eji.201142081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22539300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22539300"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "T Frodl, A Carballedo, M M Hughes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2012.14"}], "href": "https://doi.org/10.1038/tp.2012.14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22832853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22832853"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Rebecca T Hahn, Jessica Hoppstädter, Kerstin Hirschfelder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of the glucocorticoid-induced leucine zipper (GILZ) promotes vascular inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Atherosclerosis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.atherosclerosis.2014.03.028"}], "href": "https://doi.org/10.1016/j.atherosclerosis.2014.03.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24747114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24747114"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Alessandra Venanzi, Moises Di Sante, Stefano Bruscoli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recombinant long-glucocorticoid-induced leucine zipper (L-GILZ) protein restores the control of proliferation in gilz KO spermatogonia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharm Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejps.2014.06.013"}], "href": "https://doi.org/10.1016/j.ejps.2014.06.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24993177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24993177"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Mi-Jeong Lee, Rong-Ze Yang, Kalypso Karastergiou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low expression of the GILZ may contribute to adipose inflammation and altered adipokine production in human obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M067728"}], "href": "https://doi.org/10.1194/jlr.M067728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27178044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27178044"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Ayush Attery, Janendra K Batra "}, {"type": "b", "children": [{"type": "t", "text": "Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic, antibacterial and antiparasitic activities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Macromol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijbiomac.2016.10.041"}], "href": "https://doi.org/10.1016/j.ijbiomac.2016.10.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27765572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27765572"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Tanja Zeller, Claudia Schurmann, Katharina Schramm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.117.09458"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.117.09458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28784648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28784648"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Atsuhiro Kanda, Ikuyo Hirose, Kousuke Noda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoid-transactivated TSC22D3 attenuates hypoxia- and diabetes-induced Müller glial galectin-1 expression via HIF-1α destabilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15116"}], "href": "https://doi.org/10.1111/jcmm.15116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32150332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32150332"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Sara Flamini, Philipp Sergeev, Zenobio Viana de Barros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03704-w"}], "href": "https://doi.org/10.1038/s41419-021-03704-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33927191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33927191"}]}]}]}