{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe current body of literature provided focuses extensively on the roles of classical adhesion molecules—such as intercellular adhesion molecule‐1 (ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1), and their integrin partners—in orchestrating immune cell interactions, leukocyte trafficking, and inflammatory responses in diverse settings ranging from mesenchymal stem cell immunomodulation and dendritic cell–T cell priming to leukocyte diapedesis across barrier endothelium and tissue‐specific inflammatory injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " These studies characterize how cytokine‐induced upregulation, regulated mobility and ectodomain shedding of these adhesion receptors—as well as their engagement with counter‐receptors on leukocytes—determine not only the nature of cell–cell contact (brief versus prolonged) but also downstream signaling events that are critical for amplifying or quenching immune responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, these investigations also extend into how aberrant expression or function of adhesion molecules contributes to pathological conditions—including diabetic nephropathy, neuroinflammation, liver injury, fibrosis, and even tumor invasion—as well as how modulation of these pathways (by pharmacologic or genetic means) can alter disease outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": " In parallel, studies on the regulation of adhesion receptor mobility by the cytoskeleton and on the role of receptor shedding underscore the complexity and dynamic control of cell–cell interactions during immune surveillance and inflammation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nImportantly, while these abstracts provide a rich and multifaceted view of adhesion‐dependent regulation of immune cell recruitment and signaling, none of the studies directly address the function or biological role of TSGA13. In other words, despite the detailed mechanistic insights achieved for ICAM‐1, VCAM‐1, and associated molecules in various inflammatory and injury models"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "22"}]}, {"type": "t", "text": ", as well as in studies of leukocyte transmigration"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "25"}]}, {"type": "t", "text": ", there is no mention or data implicating TSGA13 in any of these processes. Thus, the function of TSGA13 remains to be delineated and may represent an as yet uncharacterized factor in the broader context of cell–cell adhesion and immune regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}, {"type": "fg_f", "ref": "15"}, {"type": "fg_fs", "start_ref": "27", "end_ref": "30"}, {"type": "fg_fs", "start_ref": "17", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the provided abstracts collectively advance our understanding of how adhesion receptor expression, shedding, and signaling mediate immune cell activation, trafficking, and tissue injury in a variety of contexts, they do not report any experimental findings on TSGA13. Consequently, the function of TSGA13 within these biological processes remains undefined based on the current literature, underscoring a gap that future experimental studies will need to address.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nazia Selzner, Markus Selzner, Bernhard Odermatt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/gast.2003.50098"}], "href": "https://doi.org/10.1053/gast.2003.50098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12612908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12612908"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Inkyu Hwang, Xuefei Shen, Jonathan Sprent "}, {"type": "b", "children": [{"type": "t", "text": "Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: distinct roles for CD54 and B7 molecules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1131852100"}], "href": "https://doi.org/10.1073/pnas.1131852100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12743365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12743365"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shinichi Okada, Kenichi Shikata, Mitsuhiro Matsuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/diabetes.52.10.2586"}], "href": "https://doi.org/10.2337/diabetes.52.10.2586"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14514644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14514644"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jaspreet S Gujral, Jie Liu, Anwar Farhood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.00318.2003"}], "href": "https://doi.org/10.1152/ajpgi.00318.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14563671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14563671"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Elodie Segura, Carole Nicco, Bérangère Lombard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2005-01-0220"}], "href": "https://doi.org/10.1182/blood-2005-01-0220"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15790784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15790784"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nina L Tsakadze, Srinivas D Sithu, Utpal Sen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M510797200"}], "href": "https://doi.org/10.1074/jbc.M510797200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16332693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16332693"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Danett K Brake, E O'Brian Smith, Harry Mersmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ICAM-1 expression in adipose tissue: effects of diet-induced obesity in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00008.2006"}], "href": "https://doi.org/10.1152/ajpcell.00008.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16807303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16807303"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Louise A Johnson, Steven Clasper, Andrew P Holt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20051759"}], "href": "https://doi.org/10.1084/jem.20051759"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17116732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17116732"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Alix Scholer, Stéphanie Hugues, Alexandre Boissonnas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2007.12.016"}], "href": "https://doi.org/10.1016/j.immuni.2007.12.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18275834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18275834"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Oliver Steiner, Caroline Coisne, Roméo Cecchelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0903732"}], "href": "https://doi.org/10.4049/jimmunol.0903732"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20861356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20861356"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Seddon Y Thomas, Seth T Scanlon, Klaus G Griewank, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20102630"}], "href": "https://doi.org/10.1084/jem.20102630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21624939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21624939"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Robert Ramer, Katharina Bublitz, Nadine Freimuth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.11-198184"}], "href": "https://doi.org/10.1096/fj.11-198184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22198381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22198381"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Guoquan Liu, Aaron T Place, Zhenlong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-12-397430"}], "href": "https://doi.org/10.1182/blood-2011-12-397430"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22806890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22806890"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Roser Gorina, Ruth Lyck, Dietmar Vestweber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1300858"}], "href": "https://doi.org/10.4049/jimmunol.1300858"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24259506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24259506"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Michael Abadier, Neda Haghayegh Jahromi, Ludmila Cardoso Alves, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.201445125"}], "href": "https://doi.org/10.1002/eji.201445125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25545837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25545837"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "William A Comrie, Shuixing Li, Sarah Boyle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201406120"}], "href": "https://doi.org/10.1083/jcb.201406120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25666808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25666808"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Abigail Woodfin, Martina Beyrau, Mathieu-Benoit Voisin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-08-664995"}], "href": "https://doi.org/10.1182/blood-2015-08-664995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26647392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26647392"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "R Sumagin, J C Brazil, P Nava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mucosal Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mi.2015.135"}], "href": "https://doi.org/10.1038/mi.2015.135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26732677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26732677"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ane M Salvador, Tania Nevers, Francisco Velázquez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload-Induced Heart Failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.115.003126"}], "href": "https://doi.org/10.1161/JAHA.115.003126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27068635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27068635"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yasumasa Ode, Monowar Aziz, Ping Wang "}, {"type": "b", "children": [{"type": "t", "text": "CIRP increases ICAM-1"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/JLB.3A0817-327RR"}], "href": "https://doi.org/10.1002/JLB.3A0817-327RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29345380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29345380"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Rémy T Boscacci, Friederike Pfeiffer, Kathrin Gollmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-11-254334"}], "href": "https://doi.org/10.1182/blood-2009-11-254334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20395417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20395417"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "David Frommhold, Anna Kamphues, Ingrid Hepper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-09-244293"}], "href": "https://doi.org/10.1182/blood-2009-09-244293"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20407037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20407037"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ronen Sumagin, Ingrid H Sarelius "}, {"type": "b", "children": [{"type": "t", "text": "Intercellular adhesion molecule-1 enrichment near tricellular endothelial junctions is preferentially associated with leukocyte transmigration and signals for reorganization of these junctions to accommodate leukocyte passage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0903319"}], "href": "https://doi.org/10.4049/jimmunol.0903319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20363969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20363969"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yong Pan, Xiuhua Zhang, Yi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting JNK by a new curcumin analog to inhibit NF-kB-mediated expression of cell adhesion molecules attenuates renal macrophage infiltration and injury in diabetic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0079084"}], "href": "https://doi.org/10.1371/journal.pone.0079084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24260158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24260158"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "R Sumagin, A Z Robin, A Nusrat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transmigrated neutrophils in the intestinal lumen engage ICAM-1 to regulate the epithelial barrier and neutrophil recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mucosal Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mi.2013.106"}], "href": "https://doi.org/10.1038/mi.2013.106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24345805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24345805"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Theresa N Ramos, Daniel C Bullard, Scott R Barnum "}, {"type": "b", "children": [{"type": "t", "text": "ICAM-1: isoforms and phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1400135"}], "href": "https://doi.org/10.4049/jimmunol.1400135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24795464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24795464"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Huan Wang, Ling-Juan Hong, Ji-Yun Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2015.61"}], "href": "https://doi.org/10.1038/cr.2015.61"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25998681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25998681"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "M Yang, J Liu, C Piao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2015.144"}], "href": "https://doi.org/10.1038/cddis.2015.144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26068788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26068788"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Felix Jansen, Xiaoyan Yang, Katharina Baumann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelial microparticles reduce ICAM-1 expression in a microRNA-222-dependent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.12607"}], "href": "https://doi.org/10.1111/jcmm.12607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26081516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26081516"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Yujie Guo, Amarjit Mishra, Emily Howland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Platelet-derived Wnt antagonist Dickkopf-1 is implicated in ICAM-1/VCAM-1-mediated neutrophilic acute lung inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-02-622233"}], "href": "https://doi.org/10.1182/blood-2015-02-622233"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26351298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26351298"}]}]}]}