| Name | thymic stromal lymphopoietin |
| Description | This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThymic stromal lymphopoietin (TSLP) is an epithelial cell–derived cytokine that plays a central role in initiating and orchestrating type 2 helper T (Th2) cell–mediated allergic inflammation. Expressed by barrier epithelial cells in the skin, airways, and gut, TSLP is markedly up‐regulated in numerous allergic disorders—including atopic dermatitis, asthma, and eosinophilic esophagitis—and is induced by proinflammatory cytokines and environmental triggers. Binding to a heterodimeric receptor complex composed of a specific TSLP receptor and the IL‑7 receptor α–chain, TSLP potently activates dendritic cells and other innate immune cells that prime naïve T cells toward Th2 differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, TSLP can act directly on activated T cells by enhancing their responsiveness to low concentrations of IL‑2 and facilitating robust Th2 cytokine production. In addition, through its ability to induce co‐stimulatory molecules such as OX40 ligand on dendritic cells, TSLP further skews T cell differentiation toward a proallergic phenotype."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEnvironmental and inflammatory stimuli—including viral infections, allergen‐derived proteases, and toll‐like receptor ligands—amplify TSLP expression in airway epithelial cells via NF‑κB–dependent pathways. As a consequence, TSLP induction leads to the production of Th2‐attracting chemokines and mediators that recruit additional effector cells and potentiate local inflammation in diseases such as asthma and chronic obstructive pulmonary disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies have further underscored the importance of TSLP by identifying polymorphisms within its gene that correlate with increased susceptibility to asthma and altered pulmonary function. Beyond its role in antigen‐presenting cell activation, TSLP modulates immune homeostasis by promoting the development of regulatory T cells in the thymus and by directly influencing the functions of mast cells and natural killer T cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to directing adaptive immune responses, TSLP contributes to chronic inflammatory remodeling and tissue fibrosis in conditions such as atopic dermatitis and allergic airway disease. Its actions extend to modulating the responses of mast cells and eosinophils, thereby integrating signals from both innate and adaptive immunity and perpetuating the allergic inflammatory milieu."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence also highlights roles for TSLP in upper airway diseases and the maintenance of immune tolerance. For example, TSLP is implicated in the pathogenesis of chronic rhinosinusitis with nasal polyps, and during pregnancy, trophoblast‐derived TSLP can shape decidual dendritic cell function to promote regulatory T cell development. In the skin, TSLP influences group 2 innate lymphoid cell responses, further demonstrating its multifaceted contributions to both protective immunity and pathologic inflammation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "30", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "P A Reche, V Soumelis, D M Gorman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.167.1.336"}], "href": "https://doi.org/10.4049/jimmunol.167.1.336"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11418668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11418668"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Vassili Soumelis, Pedro A Reche, Holger Kanzler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni805"}], "href": "https://doi.org/10.1038/ni805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12055625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12055625"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sun Ying, Brian O'Connor, Jonathan Ratoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.174.12.8183"}], "href": "https://doi.org/10.4049/jimmunol.174.12.8183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15944327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15944327"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Steven F Ziegler, Yong-Jun Liu "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin in normal and pathogenic T cell development and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni1360"}], "href": "https://doi.org/10.1038/ni1360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16785889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16785889"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hai-Chon Lee, Steven F Ziegler "}, {"type": "b", "children": [{"type": "t", "text": "Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0607305104"}], "href": "https://doi.org/10.1073/pnas.0607305104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17213320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17213320"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Irina Rochman, Norihiko Watanabe, Kazuhiko Arima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.178.11.6720"}], "href": "https://doi.org/10.4049/jimmunol.178.11.6720"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17513717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17513717"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yui-Hsi Wang, Pornpimon Angkasekwinai, Ning Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20070406"}], "href": "https://doi.org/10.1084/jem.20070406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17635955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17635955"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yong-Jun Liu "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2007.06.004"}], "href": "https://doi.org/10.1016/j.jaci.2007.06.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17666213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17666213"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dhaya Seshasayee, Wyne P Lee, Meijuan Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI33559"}], "href": "https://doi.org/10.1172/JCI33559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18060034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18060034"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sun Ying, Brian O'Connor, Jonathan Ratoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.181.4.2790"}], "href": "https://doi.org/10.4049/jimmunol.181.4.2790"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18684970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18684970"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "J Tanaka, N Watanabe, M Kido, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2-polarizing conditions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Allergy (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2222.2008.03151.x"}], "href": "https://doi.org/10.1111/j.1365-2222.2008.03151.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19055649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19055649"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hirokazu Kinoshita, Toshiro Takai, Tuan Anh Le, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2008.10.008"}], "href": "https://doi.org/10.1016/j.jaci.2008.10.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19056108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19056108"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mark B Headley, Baohua Zhou, Weihui X Shih, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.182.3.1641"}], "href": "https://doi.org/10.4049/jimmunol.182.3.1641"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19155513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19155513"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hideaki Kouzaki, Scott M O'Grady, Christopher B Lawrence, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0900904"}], "href": "https://doi.org/10.4049/jimmunol.0900904"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19561109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19561109"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kazuhiko Arima, Norihiko Watanabe, Shino Hanabuchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct signal codes generate dendritic cell functional plasticity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2000567"}], "href": "https://doi.org/10.1126/scisignal.2000567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20086239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20086239"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Rui He, Raif S Geha "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann N Y Acad Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1749-6632.2009.05128.x"}], "href": "https://doi.org/10.1111/j.1749-6632.2009.05128.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20146705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20146705"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Shino Hanabuchi, Tomoki Ito, Woon-Ryon Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0804106"}], "href": "https://doi.org/10.4049/jimmunol.0804106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20173030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20173030"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Marc E Rothenberg, Jonathan M Spergel, Joseph D Sherrill, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants at 5q22 associate with pediatric eosinophilic esophagitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.547"}], "href": "https://doi.org/10.1038/ng.547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20208534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20208534"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Abdelhabib Semlali, Eric Jacques, Latifa Koussih, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2010.01.044"}], "href": "https://doi.org/10.1016/j.jaci.2010.01.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20236697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20236697"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "G M Hunninghake, M E Soto-Quirós, L Avila, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSLP polymorphisms are associated with asthma in a sex-specific fashion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Allergy (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1398-9995.2010.02415.x"}], "href": "https://doi.org/10.1111/j.1398-9995.2010.02415.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20560908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20560908"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Michishige Harada, Tomomitsu Hirota, Aya I Jodo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2009-0418OC"}], "href": "https://doi.org/10.1165/rcmb.2009-0418OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20656951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20656951"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yrina Rochman, Mohit Kashyap, Gertraud W Robinson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1008271107"}], "href": "https://doi.org/10.1073/pnas.1008271107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20974963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20974963"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Phil-Dong Moon, Hyung-Min Kim "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-κB pathway in mast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cyto.2011.03.007"}], "href": "https://doi.org/10.1016/j.cyto.2011.03.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21463955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21463955"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Min-Hee Oh, Sun Young Oh, Jinho Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1100504"}], "href": "https://doi.org/10.4049/jimmunol.1100504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21576506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21576506"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Carole Ober, Tsung-Chieh Yao "}, {"type": "b", "children": [{"type": "t", "text": "The genetics of asthma and allergic disease: a 21st century perspective."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Rev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-065X.2011.01029.x"}], "href": "https://doi.org/10.1111/j.1600-065X.2011.01029.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21682736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21682736"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "De-Quan Li, Lili Zhang, Stephen C Pflugfelder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2011.06.041"}], "href": "https://doi.org/10.1016/j.jaci.2011.06.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21820713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21820713"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Aarti Shikotra, David F Choy, Chandra M Ohri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2011.08.031"}], "href": "https://doi.org/10.1016/j.jaci.2011.08.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21975173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21975173"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Deepti R Nagarkar, Julie A Poposki, Michael R Comeau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Airway epithelial cells activate TH2 cytokine production in mast cells through IL-1 and thymic stromal lymphopoietin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2012.04.019"}], "href": "https://doi.org/10.1016/j.jaci.2012.04.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22633328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22633328"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Hai-Chon Lee, Mark B Headley, Yueh-Ming Loo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2012.07.031"}], "href": "https://doi.org/10.1016/j.jaci.2012.07.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22981788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22981788"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Brian S Kim, Mark C Siracusa, Steven A Saenz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.3005374"}], "href": "https://doi.org/10.1126/scitranslmed.3005374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23363980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23363980"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Steven F Ziegler, Florence Roan, Bryan D Bell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The biology of thymic stromal lymphopoietin (TSLP)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Pharmacol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/B978-0-12-404717-4.00004-4"}], "href": "https://doi.org/10.1016/B978-0-12-404717-4.00004-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23433457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23433457"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Deepti R Nagarkar, Julie A Poposki, Bruce K Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2013.04.005"}], "href": "https://doi.org/10.1016/j.jaci.2013.04.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23688414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23688414"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Mario Noti, Elia D Tait Wojno, Brian S Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.3281"}], "href": "https://doi.org/10.1038/nm.3281"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23872715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23872715"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Mei-Rong Du, Pei-Fen Guo, Hai-Lan Piao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1203425"}], "href": "https://doi.org/10.4049/jimmunol.1203425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24453244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24453244"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Clare M Lloyd, Sejal Saglani "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial cytokines and pulmonary allergic inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Opin Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.coi.2015.02.001"}], "href": "https://doi.org/10.1016/j.coi.2015.02.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25705788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25705788"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Giulia Fornasa, Katerina Tsilingiri, Flavio Caprioli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2015.04.011"}], "href": "https://doi.org/10.1016/j.jaci.2015.04.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26014813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26014813"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "B Liao, P-P Cao, M Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Allergy (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/all.12667"}], "href": "https://doi.org/10.1111/all.12667"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26095319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26095319"}]}]}]}
|
| Proteins | TSLP_HUMAN |
| NCBI Gene ID | 85480 |
| API | |
| Download Associations | |
| Predicted Functions |
![]() |
| Co-expressed Genes |
![]() |
| Expression in Tissues and Cell Lines |
![]() |
TSLP has 6,257 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 103 datasets.
Click the + buttons to view associations for TSLP from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by TSLP gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of TSLP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TSLP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of TSLP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of TSLP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TSLP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TSLP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of TSLP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of TSLP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with TSLP gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TSLP gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of TSLP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of TSLP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing TSLP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with TSLP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TSLP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of TSLP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with TSLP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with TSLP gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with TSLP gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with TSLP gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by TSLP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with TSLP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with TSLP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with TSLP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TSLP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with TSLP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with TSLP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TSLP gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TSLP gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of TSLP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing TSLP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with TSLP gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with TSLP gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with TSLP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing TSLP from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of TSLP gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TSLP gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of TSLP gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TSLP gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of TSLP gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of TSLP gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving TSLP gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving TSLP gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing TSLP protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by TSLP gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by TSLP gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by TSLP gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of TSLP gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of TSLP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TSLP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TSLP gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with TSLP gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with TSLP gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with TSLP gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with TSLP gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of TSLP gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of TSLP gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of TSLP gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TSLP gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for TSLP from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuBMAP ASCT+B Annotations | cell types associated with TSLP gene from the HuBMAP ASCT+B dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with TSLP gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with TSLP gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with TSLP gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for TSLP protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TSLP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of TSLP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of TSLP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving TSLP protein from the KEGG Pathways dataset. | |
| KEGG Pathways 2026 | pathways involving TSLP protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of TSLP gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of TSLP gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing TSLP protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain TSLP protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by TSLP gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting TSLP gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of TSLP gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by TSLP gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of TSLP gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for TSLP from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TSLP gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of TSLP gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving TSLP protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving TSLP protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2024 | pathways involving TSLP protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of TSLP gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of TSLP gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TSLP gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TSLP gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TSLP gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of TSLP gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of TSLP gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of TSLP gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of TSLP gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of TSLP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TSLP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of TSLP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TSLP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with TSLP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TSLP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving TSLP protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving TSLP protein from the WikiPathways Pathways 2024 dataset. | |