| HGNC Family | Tetraspanins (TSPAN) |
| Name | tetraspanin 1 |
| Description | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTSPAN1, a member of the tetraspanin family, is frequently dysregulated in human cancers. In several solid tumors—including cervical, hepatocellular, gastric, colorectal, pancreatic, ovarian, and even subsets of prostate and nasopharyngeal carcinomas—elevated TSPAN1 (often referred to as NET‐1) has been linked with increased neoplastic cell proliferation, enhanced invasion and migration and, in many instances, poorer patient survival. In certain contexts, however, its expression may be reduced or demonstrate context‐dependent behavior affecting cell cycle regulation and metastatic progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, TSPAN1 exerts its effects through multiple signaling pathways and molecular interactions. It can promote autophagy via direct binding to LC3 through conserved LC3‐interacting region (LIR) motifs, modulate phospholipase Cγ signaling that in turn regulates matrix metalloproteinase‐2 expression, and influence key pathways such as PI3K/Akt, NF‑κB, and Wnt/β‑catenin. Its expression is tightly controlled by microRNAs (for example, miR‑638, miR‑573, and miR‑491‑3p) and transcription factors acting via TCF/LEF binding sites. In addition, proper N‑glycosylation is necessary for its folding and stability, and TSPAN1 has been shown to interact with other proteins such as the thiamine transporter hTHTR‑1—thereby prolonging its half‑life—which further emphasizes its multifaceted role in cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in cancer, TSPAN1 has been implicated in non‐neoplastic conditions as well. For instance, in idiopathic pulmonary fibrosis TSPAN1 downregulation is associated with exacerbated TGF‑β–induced epithelial-to-mesenchymal transition, while emerging evidence suggests that it may also modulate B cell functions in autoimmune hepatitis. Collectively, these studies support the evolving view of TSPAN1 as a promising prognostic biomarker and therapeutic target, given its diverse involvement in cell proliferation, invasion, autophagy and other critical signaling events across multiple disease states."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Volker Wollscheid, Rosemarie Kühne-Heid, Ines Stein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.10442"}], "href": "https://doi.org/10.1002/ijc.10442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12115476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12115476"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li Chen, Zhiwei Wang, Xi Zhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of NET-1 gene expression with human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Surg Pathol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1066896907306083"}], "href": "https://doi.org/10.1177/1066896907306083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17913940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17913940"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Li Chen, Xinyu Li, Guei-Lan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathological significance of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumori (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/030089160809400415"}], "href": "https://doi.org/10.1177/030089160809400415"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18822690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18822690"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Claus-Jürgen Scholz, Christian Kurzeder, Karin Koretz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tspan-1 is a tetraspanin preferentially expressed by mucinous and endometrioid subtypes of human ovarian carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2008.10.014"}], "href": "https://doi.org/10.1016/j.canlet.2008.10.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19017553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19017553"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Claus-Jürgen Scholz, Georg Sauer, Helmut Deissler "}, {"type": "b", "children": [{"type": "t", "text": "Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Pept Lett (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/092986609789071234"}], "href": "https://doi.org/10.2174/092986609789071234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19508227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19508227"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Li Chen, Daiyue Yuan, Gui-lan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathological significance of expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Korean Med Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3346/jkms.2010.25.10.1438"}], "href": "https://doi.org/10.3346/jkms.2010.25.10.1438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20890423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20890423"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Li Chen, Daiyue Yuan, Ren Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of TSPAN1 by RNA interference inhibits proliferation and invasion of colon cancer cells in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumori (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/030089161009600517"}], "href": "https://doi.org/10.1177/030089161009600517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21302622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21302622"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yu-kun Huang, Xue-gong Fan, Fu Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomics of hepatitis B virus-related hepatocellular carcinoma and adjacent noncancerous tissues with cDNA microarray."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chin Med J (Engl) (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22088470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22088470"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yaqing Chen, Wei Peng, Yixiang Lu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2499"}], "href": "https://doi.org/10.18632/oncotarget.2499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25301729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25301729"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zhengmao Lu, Tianhang Luo, Mingming Nie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2015.05.044"}], "href": "https://doi.org/10.1016/j.febslet.2015.05.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26054975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26054975"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Feng-Qiang Hou, Xi-Feng Lei, Jian-Long Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tetraspanin 1 is involved in survival, proliferation and carcinogenesis of pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4272"}], "href": "https://doi.org/10.3892/or.2015.4272"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26370588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26370588"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Fan Xu, Yujing Gao, Yanqing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased TSPAN1 promotes prostate cancer progression and is a marker for early biochemical recurrence after radical prostatectomy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11448"}], "href": "https://doi.org/10.18632/oncotarget.11448"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27556508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27556508"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ha-Yeon Shin, Wookyeom Yang, Doo Byung Chay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tetraspanin 1 promotes endometriosis leading to ovarian clear cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12884"}], "href": "https://doi.org/10.1002/1878-0261.12884"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33331115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33331115"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Melissa Stinnesbeck, Anna Kristiansen, Jörg Ellinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "APMIS (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/apm.13117"}], "href": "https://doi.org/10.1111/apm.13117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33455017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33455017"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ming-Dian Wang, Hui-Ting Li, Li-Xia Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41417-023-00716-w"}], "href": "https://doi.org/10.1038/s41417-023-00716-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38135697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38135697"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xudong Zhao, Zhiqiang Zhao, Honglin Xie, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ALKBH5"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Suppresses Autophagy in Prostate Cancer Cells via Inhibiting m6A-Modification of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TSPAN1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Discov Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.24976/Discov.Med.202436180.5"}], "href": "https://doi.org/10.24976/Discov.Med.202436180.5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38273746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38273746"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Svetlana M Nabokina, Sundar Rajan Senthilkumar, Hamid M Said "}, {"type": "b", "children": [{"type": "t", "text": "Tspan-1 interacts with the thiamine transporter-1 in human intestinal epithelial cells and modulates its stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.00269.2011"}], "href": "https://doi.org/10.1152/ajpgi.00269.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21836059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21836059"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Junhu Duan, Jiangtao Liu, Yin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-491-3p suppresses the growth and invasion of osteosarcoma cells by targeting TSPAN1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7256"}], "href": "https://doi.org/10.3892/mmr.2017.7256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28849017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28849017"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Lawei Yang, Yahong Wang, Zhanchun Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tetraspanin 1 inhibits TNFα-induced apoptosis via NF-κB signaling pathway in alveolar epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inflamm Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00011-018-1189-9"}], "href": "https://doi.org/10.1007/s00011-018-1189-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30291375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30291375"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Xiaobo Zhang, Gang Shi, Feng Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.6989"}], "href": "https://doi.org/10.3892/or.2019.6989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30720116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30720116"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Gang Liu, Yahong Wang, Lawei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tetraspanin 1 as a mediator of fibrosis inhibits EMT process and Smad2/3 and beta-catenin pathway in human pulmonary fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14258"}], "href": "https://doi.org/10.1111/jcmm.14258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30869194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30869194"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Chenhui Ma, ZeLong Cui, YiChao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bioinformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bosn J Basic Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17305/bjbms.2020.5096"}], "href": "https://doi.org/10.17305/bjbms.2020.5096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33188589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33188589"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Lei Wang, Peng Gao, Ping Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-573 suppresses pancreatic cancer cell proliferation, migration, and invasion through targeting TSPAN1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Strahlenther Onkol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00066-020-01728-3"}], "href": "https://doi.org/10.1007/s00066-020-01728-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33320287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33320287"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yange Wu, Wenxiu Chen, Yufeng Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tetraspanin 1 (TSPAN1) promotes growth and transferation of breast cancer cells via mediating PI3K/Akt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2003130"}], "href": "https://doi.org/10.1080/21655979.2021.2003130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34852709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34852709"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yiyan Ou, Ruiling Chen, Qiwei Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The immunological characteristics of TSPAN1 expressing B cells in autoimmune hepatitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2022.1076594"}], "href": "https://doi.org/10.3389/fimmu.2022.1076594"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36591302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36591302"}]}]}]}
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| Synonyms | TM4SF, TM4C |
| Proteins | TSN1_HUMAN |
| NCBI Gene ID | 10103 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TSPAN1 has 7,106 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 106 datasets.
Click the + buttons to view associations for TSPAN1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of TSPAN1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TSPAN1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of TSPAN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of TSPAN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of TSPAN1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of TSPAN1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TSPAN1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TSPAN1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of TSPAN1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of TSPAN1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of TSPAN1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with TSPAN1 protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with TSPAN1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TSPAN1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of TSPAN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of TSPAN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of TSPAN1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TSPAN1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing TSPAN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing TSPAN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with TSPAN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TSPAN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of TSPAN1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with TSPAN1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with TSPAN1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by TSPAN1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with TSPAN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TSPAN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with TSPAN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with TSPAN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TSPAN1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TSPAN1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of TSPAN1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing TSPAN1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with TSPAN1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of TSPAN1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with TSPAN1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing TSPAN1 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of TSPAN1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TSPAN1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of TSPAN1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TSPAN1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of TSPAN1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of TSPAN1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding TSPAN1 protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving TSPAN1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving TSPAN1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving TSPAN1 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing TSPAN1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing TSPAN1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing TSPAN1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by TSPAN1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of TSPAN1 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of TSPAN1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TSPAN1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TSPAN1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of TSPAN1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with TSPAN1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of TSPAN1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of TSPAN1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of TSPAN1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of TSPAN1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TSPAN1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HuBMAP ASCT+B Annotations | cell types associated with TSPAN1 gene from the HuBMAP ASCT+B dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with TSPAN1 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with TSPAN1 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with TSPAN1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for TSPAN1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TSPAN1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of TSPAN1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of TSPAN1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of TSPAN1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of TSPAN1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with TSPAN1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of TSPAN1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of TSPAN1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of TSPAN1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TSPAN1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain TSPAN1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of TSPAN1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of TSPAN1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of TSPAN1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of TSPAN1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for TSPAN1 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TSPAN1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of TSPAN1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving TSPAN1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving TSPAN1 protein from the Wikipathways PFOCR 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TSPAN1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TSPAN1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of TSPAN1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TSPAN1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TSPAN1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with TSPAN1 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of TSPAN1 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of TSPAN1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of TSPAN1 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of TSPAN1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of TSPAN1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of TSPAN1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of TSPAN1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TSPAN1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of TSPAN1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TSPAN1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with TSPAN1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TSPAN1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
