TSPAN7 Gene

HGNC Family	Tetraspanins (TSPAN), X-linked mental retardation, CD molecules (CD)
Name	tetraspanin 7
Description	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked cognitive disability and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTSPAN7 is a multifaceted protein crucial for proper neuronal development and synaptic function. Rare variants in TSPAN7 have been linked to neurodevelopmental disorders—including autism spectrum disorder and schizophrenia—by affecting neurite outgrowth. In hippocampal neurons, TSPAN7 overexpression drives the formation of filopodia and dendritic spines while its depletion leads to reduced spine head size and diminished AMPA receptor currents. Moreover, TSPAN7 interacts via its C terminus with PICK1 to regulate AMPA receptor trafficking and modulates dopamine D2 receptor internalization, thereby influencing dopaminergic signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncological contexts, TSPAN7 has emerged as an important biomarker and potential regulator of tumor progression. In clear‐cell renal cell carcinoma, higher TSPAN7 expression is associated with longer disease‐free and tumor‐specific survival, while increased TSPAN7 levels are observed in several cancer types. Although the precise molecular mechanisms underlying its role in tumor biology remain under investigation, current findings underscore TSPAN7’s importance as a scaffold protein that organizes cell surface receptors and modulates signaling pathways critical for cell adhesion and migration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTSPAN7 is also implicated in immune regulation and autoimmunity. It serves as an autoantigen in type 1 diabetes, with autoantibodies against the protein marking impaired β‐cell function and altered L‐type Ca²⁺ channel activity. In dendritic cells, TSPAN7 positively regulates actin nucleation through the ARP2/3 complex, limiting endocytosis and facilitating the retention of viral particles on actin‐rich dendrites for efficient HIV‐1 transfer to T lymphocytes. Additionally, interactions between TSPAN7 and proteins involved in reproductive immunity suggest a role in fertility pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, TSPAN7 has been identified as a putative antigenic target in autoimmune conditions such as Wegener’s granulomatosis, further highlighting its diverse roles in immune recognition and disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A Piton, J Gauthier, F F Hamdan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2010.54"}], "href": "https://doi.org/10.1038/mp.2010.54"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20479760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20479760"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Silvia Bassani, Lorenzo A Cingolani, Pamela Valnegri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2012.01.021"}], "href": "https://doi.org/10.1016/j.neuron.2012.01.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22445342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22445342"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Seol-Ae Lee, Yeongjun Suh, Saebom Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201600755RR"}], "href": "https://doi.org/10.1096/fj.201600755RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28223337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28223337"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Brieuc P Perot, Mickaël M Ménager "}, {"type": "b", "children": [{"type": "t", "text": "Tetraspanin 7 and its closest paralog tetraspanin 6: membrane organizers with key functions in brain development, viral infection, innate immunity, diabetes and cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Microbiol Immunol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00430-020-00681-3"}], "href": "https://doi.org/10.1007/s00430-020-00681-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32468130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32468130"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Daniela Wuttig, Stefan Zastrow, Susanne Füssel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.27419"}], "href": "https://doi.org/10.1002/ijc.27419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22213152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22213152"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chee Man Cheong, Annie W S Chow, Stephen Fitter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2015.01.006"}], "href": "https://doi.org/10.1016/j.yexcr.2015.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25637218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25637218"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Bingnan Lu, Yifan Liu, Yuntao Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unveiling the unique role of TSPAN7 across tumors: a pan-cancer study incorporating retrospective clinical research and bioinformatic analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Direct (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13062-024-00516-8"}], "href": "https://doi.org/10.1186/s13062-024-00516-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39175035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39175035"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Monika Mrozowska, Tomasz Górnicki, Mateusz Olbromski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New insights into the role of tetraspanin 6, 7, and 8 in physiology and pathology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.7390"}], "href": "https://doi.org/10.1002/cam4.7390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39031113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39031113"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kerry A McLaughlin, Melissa A Tombs, Michael R Christie "}, {"type": "b", "children": [{"type": "t", "text": "Autoimmunity to tetraspanin-7 in type 1 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Microbiol Immunol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00430-020-00674-2"}], "href": "https://doi.org/10.1007/s00430-020-00674-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32314012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32314012"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kerry McLaughlin, Samuel Acreman, Sameena Nawaz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " sensitivity but has limited effect on systemic metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabet Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/dme.14984"}], "href": "https://doi.org/10.1111/dme.14984"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36264270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36264270"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mickaël M Ménager "}, {"type": "b", "children": [{"type": "t", "text": "TSPAN7, effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Soc Trans (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BST20160439"}], "href": "https://doi.org/10.1042/BST20160439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28620031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28620031"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Brieuc P Perot, Victor García-Paredes, Marine Luka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " T Lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Infect Microbiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcimb.2020.00070"}], "href": "https://doi.org/10.3389/fcimb.2020.00070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32181159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32181159"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yashwanth Radhakrishnan, Katherine G Hamil, Jiann-An Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel partners of SPAG11B isoform D in the human male reproductive tract."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.109.077545"}], "href": "https://doi.org/10.1095/biolreprod.109.077545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19535787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19535787"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Lorenz Thurner, Antje Müller, Martine Cérutti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wegener's granuloma harbors B lymphocytes with specificities against a proinflammatory transmembrane protein and a tetraspanin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Autoimmun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaut.2010.09.002"}], "href": "https://doi.org/10.1016/j.jaut.2010.09.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20951001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20951001"}]}]}]}
Synonyms	TALLA-1, TM4SF2, MXS1, CD231, DXS1692E, TM4SF2B, CCG-B7, MRX58, A15
Proteins	TSN7_HUMAN
NCBI Gene ID	7102
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TSPAN7 has 8,937 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for TSPAN7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TSPAN7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TSPAN7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TSPAN7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TSPAN7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TSPAN7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TSPAN7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TSPAN7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TSPAN7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TSPAN7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TSPAN7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TSPAN7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TSPAN7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TSPAN7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TSPAN7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TSPAN7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TSPAN7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TSPAN7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TSPAN7 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TSPAN7 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TSPAN7 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TSPAN7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TSPAN7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TSPAN7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TSPAN7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TSPAN7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TSPAN7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TSPAN7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TSPAN7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TSPAN7 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TSPAN7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving TSPAN7 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TSPAN7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TSPAN7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TSPAN7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TSPAN7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TSPAN7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TSPAN7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TSPAN7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TSPAN7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TSPAN7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with TSPAN7 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.