TUSC2 Gene

Name	tumor suppressor candidate 2
Description	Predicted to be involved in inflammatory response and regulation of mitochondrial membrane potential. Predicted to act upstream of or within several processes, including natural killer cell differentiation; neutrophil-mediated killing of gram-negative bacterium; and regulation of cytokine production. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTUSC2 (also known as FUS1) is a critical tumor suppressor gene located in the 3p21.3 chromosomal region that is frequently lost or downregulated in multiple human cancers—including lung cancer, malignant pleural mesothelioma, and others—contributing to tumor progression. Its expression inhibits cell proliferation, colony formation, migration and invasion, and enhances apoptosis through modulation of key cellular processes. In lung and other cancers, restoration of TUSC2 expression leads to marked inhibition of tumor growth, and proper posttranslational modifications (such as N‐myristoylation) are essential for its tumor‐suppressive function. Moreover, even in cases of allelic loss or mutation, low expression of TUSC2 correlates with aggressive disease and poor overall survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTUSC2 expression is tightly regulated at the post‐transcriptional and translational levels. Regulatory elements within its untranslated regions (UTRs) act as checkpoints, while a cadre of oncogenic microRNAs—including miR‑19a, miR‑584, miR‑663b, and miR‑138—directly target its mRNA, leading to reduced protein expression and diminished tumor suppressor activity. In addition, transcripts from TUSC2 pseudogenes (TUSC2P) share common microRNA binding sites with TUSC2 and can sequester these microRNAs, thereby relieving translational repression and restoring TUSC2 protein levels. Furthermore, reduced FUS1 expression has also been documented in sarcomas, underscoring its broad role as a tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "14"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTherapeutically, restoration of TUSC2 expression in cancer cells has shown promise by not only curbing tumorigenesis directly but also by enhancing sensitivity to targeted agents such as epidermal growth factor receptor (EGFR) inhibitors and AKT inhibitors. Re‐establishment of TUSC2 function modulates critical signaling pathways—including inhibition of AKT/mTOR, activation of AMP‐activated protein kinase (AMPK), downregulation of oncogenic factors like FGFR2 and Bcl‑xL, and enhancement of apoptotic signaling—to overcome drug resistance. In parallel, studies have revealed that aberrant degradation of TUSC2 by E3 ubiquitin ligase (NEDD4-mediated polyubiquitination) further contributes to its loss in malignancies such as glioblastoma. These findings suggest that strategies designed to restore or stabilize TUSC2 function might offer innovative therapeutic avenues for otherwise intractable cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "19"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M Kondo, L Ji, C Kamibayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1204832"}], "href": "https://doi.org/10.1038/sj.onc.1204832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11593436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11593436"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Futoshi Uno, Jiichiro Sasaki, Masahiko Nishizaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.can-03-3702"}], "href": "https://doi.org/10.1158/0008-5472.can-03-3702"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15126327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15126327"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bao Zhang, Xia Huo, Lin Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Recombinant prokaryotic plasmid construction and high expression of FUS1 gene]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17545076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17545076"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Daniel Y Lee, Zhaoqun Deng, Chia-Hui Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0706901104"}], "href": "https://doi.org/10.1073/pnas.0706901104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18077375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18077375"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ludmila Prudkin, Carmen Behrens, Diane D Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-07-1252"}], "href": "https://doi.org/10.1158/1078-0432.CCR-07-1252"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18172250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18172250"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Liqin Du, Jeoffrey J Schageman, Maria C Subauste, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-08-0507"}], "href": "https://doi.org/10.1158/1541-7786.MCR-08-0507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19671678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19671678"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Alla V Ivanova, Sergey V Ivanov, Ljudmila Prudkin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-8-91"}], "href": "https://doi.org/10.1186/1476-4598-8-91"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19852844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19852844"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Guidong Li, Hiroyuki Kawashima, Lin Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent absence of tumor suppressor FUS1 protein expression in human bone and soft tissue sarcomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21273575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21273575"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jing Lin, Kai Xu, Jayachandran Gitanjali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of tumor suppressor gene FUS1 expression by the untranslated regions of mRNA in human lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.05.122"}], "href": "https://doi.org/10.1016/j.bbrc.2011.05.122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21645495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21645495"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zina Jeyapalan Rutnam, William W Du, Weining Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms3914"}], "href": "https://doi.org/10.1038/ncomms3914"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24394498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24394498"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kumiko Yamamoto, Sachio Ito, Hiroko Hanafusa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0137887"}], "href": "https://doi.org/10.1371/journal.pone.0137887"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26367773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26367773"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Francesca Maria Orlandella, Gennaro Di Maro, Clara Ugolini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TWIST1/miR-584/TUSC2 pathway induces resistance to apoptosis in thyroid cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12129"}], "href": "https://doi.org/10.18632/oncotarget.12129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27661106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27661106"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jianying Chen, Bo Song, Guangqi Kong "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑663b downregulation inhibits proliferation and induces apoptosis in bladder cancer cells by targeting TUSC2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10023"}], "href": "https://doi.org/10.3892/mmr.2019.10023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30896880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30896880"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Srikanth Nama, Manish Muhuri, Federica Di Pascale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-49155-4"}], "href": "https://doi.org/10.1038/s41598-019-49155-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31481748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31481748"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jieru Meng, Mourad Majidi, Bingliang Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0077067"}], "href": "https://doi.org/10.1371/journal.pone.0077067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24146957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24146957"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Bingbing Dai, Shaoyu Yan, Humberto Lara-Guerra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exogenous Restoration of TUSC2 Expression Induces Responsiveness to Erlotinib in Wildtype Epidermal Growth Factor Receptor (EGFR) Lung Cancer Cells through Context Specific Pathways Resulting in Enhanced Therapeutic Efficacy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0123967"}], "href": "https://doi.org/10.1371/journal.pone.0123967"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26053020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26053020"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Cao Xiaobo, Mourad Majidi, Meng Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep35741"}], "href": "https://doi.org/10.1038/srep35741"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27845352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27845352"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Raffaela Mariarosaria Mariniello, Francesca Maria Orlandella, Anna Elisa De Stefano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The TUSC2 Tumour Suppressor Inhibits the Malignant Phenotype of Human Thyroid Cancer Cells via SMAC/DIABLO Protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21030702"}], "href": "https://doi.org/10.3390/ijms21030702"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31973107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31973107"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Tadas K Rimkus, Austin B Arrigo, Dongqin Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD4 degrades TUSC2 to promote glioblastoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2022.01.029"}], "href": "https://doi.org/10.1016/j.canlet.2022.01.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35167936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35167936"}]}]}]}
Synonyms	PDAP2, C3ORF11
Proteins	TUSC2_HUMAN
NCBI Gene ID	11334
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TUSC2 has 5,764 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 110 datasets.

Click the + buttons to view associations for TUSC2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TUSC2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by TUSC2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TUSC2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TUSC2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TUSC2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TUSC2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TUSC2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TUSC2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TUSC2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TUSC2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TUSC2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TUSC2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TUSC2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TUSC2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TUSC2 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TUSC2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TUSC2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TUSC2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TUSC2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TUSC2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TUSC2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TUSC2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TUSC2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TUSC2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TUSC2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TUSC2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TUSC2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TUSC2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TUSC2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TUSC2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TUSC2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TUSC2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TUSC2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TUSC2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TUSC2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TUSC2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TUSC2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TUSC2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TUSC2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TUSC2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TUSC2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.