{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUBAP2L is emerging as a multifunctional regulator in RNA metabolism and the cellular stress response. It plays a pivotal role as a core nucleator of stress granules by operating upstream of key granule components (e.g., G3BP1/2), with its arginine‐glycine rich (RGG) motif being essential for the recruitment of messenger ribonucleoprotein complexes. In addition, UBAP2L enhances the translation of target mRNAs and contributes to the degradation of stalled RNA polymerase II—a role that positions it as the human functional counterpart of yeast Def1—thereby integrating stress‐induced translational inhibition with mRNA metabolic regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in stress granule dynamics and RNA regulation, UBAP2L contributes importantly to cell cycle control and oncogenesis. It interacts with the Polycomb group protein BMI1 to regulate hematopoietic stem cell activity, and its dysregulated expression promotes tumor growth and metastasis in a range of cancers—including breast, prostate, glioma, hepatocellular, gastric, and uterine cervical carcinomas. UBAP2L is also crucial for correct kinetochore–microtubule attachments during mitosis, with post‐translational modifications (such as arginine methylation by PRMT1) fine-tuning its activity. Its aberrant expression impacts several critical signaling pathways (including PI3K/AKT, p53, Wnt/β-catenin, and AKT/mTOR), thereby influencing cellular proliferation, survival, angiogenesis, and metabolic reprogramming."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementing its cytoplasmic and oncogenic functions, UBAP2L also plays an essential role in nuclear architecture by facilitating the assembly and stability of nuclear pore complexes (NPCs). By promoting the interaction and incorporation of scaffold components—particularly the Y-complex—with key nucleoporins such as POM121, Nup153, and the transport factor FXR1, UBAP2L ensures efficient nucleocytoplasmic transport and maintains proper cellular proliferative capacity and stress adaptation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chuyu Huang, Yan Chen, Huaiqian Dai, et al. 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