UBASH3B Gene

Name	ubiquitin associated and SH3 domain containing B
Description	This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUBASH3B, also known as STS-1 or TULA-2, has emerged as a critical modulator of oncogenic signaling in diverse malignancies. In triple‐negative breast cancer, UBASH3B is overexpressed and supports malignant growth, invasion, and metastasis largely by modulating epidermal growth factor receptor (EGFR) signaling. Its phosphatase activity targets the E3 ubiquitin ligase CBL for dephosphorylation and inactivation, thereby impairing EGFR ubiquitination and degradation. In acute myeloid leukemia, transcriptional and microRNA‐mediated upregulation of UBASH3B by the AML1–ETO fusion protein promotes myeloid proliferation, while in leukemic cells, aberrant induction of UBASH3B leads to dephosphorylation and degradation of protein kinase Cδ that contributes to drug resistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn immune and hematopoietic cells, UBASH3B functions as a potent negative regulator of receptor‐mediated signaling. Through its robust tyrosine phosphatase activity, UBASH3B dephosphorylates key signaling molecules such as Syk and Zap‑70, thereby attenuating T‑cell receptor signaling and modulating platelet activation. Substrate‐trapping experiments have validated its direct interaction with tyrosine‐phosphorylated targets, while additional studies have linked UBASH3B activity to the control of interferon‑α–induced autophagy in B cells—an effect that may contribute to the pathogenesis of autoimmune disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in oncogenic and immunoregulatory pathways, UBASH3B plays a key role in ensuring proper cell division. It directly interacts with ubiquitylated Aurora B kinase, guiding its localization to microtubules and thereby safeguarding the timing and fidelity of chromosome segregation during mitosis. Moreover, genetic investigations have identified polymorphisms in the UBASH3B gene that are associated with immune‐mediated conditions such as Behçet’s disease, underscoring its multifaceted impact on cellular regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuet Theng Lee, Min Feng, Yong Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1300873110"}], "href": "https://doi.org/10.1073/pnas.1300873110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23784775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23784775"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "S Goyama, J Schibler, A Gasilina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2015.275"}], "href": "https://doi.org/10.1038/leu.2015.275"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26449661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26449661"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yao Yao, Wuling Liu, Babu Gajendran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCδ protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochimie (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biochi.2021.02.001"}], "href": "https://doi.org/10.1016/j.biochi.2021.02.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33556471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33556471"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jie Wang, Chunlin Wang, Anling Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-024-12075-2"}], "href": "https://doi.org/10.1186/s12885-024-12075-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38461240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38461240"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Boris S Luis, Nick Carpino "}, {"type": "b", "children": [{"type": "t", "text": "Insights into the suppressor of T-cell receptor (TCR) signaling-1 (Sts-1)-mediated regulation of TCR signaling through the use of novel substrate-trapping Sts-1 phosphatase variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.12615"}], "href": "https://doi.org/10.1111/febs.12615"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24256567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24256567"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Guanjun Dong, Ming You, Hongye Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STS-1 promotes IFN-α induced autophagy by activating the JAK1-STAT1 signaling pathway in B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.201445349"}], "href": "https://doi.org/10.1002/eji.201445349"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25959715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25959715"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Talitha van der Meulen, Spencer Swarts, Wolfgang Fischer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of STS-1 as a novel ShcA-binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.07.024"}], "href": "https://doi.org/10.1016/j.bbrc.2017.07.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28690151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28690151"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Alexander Y Tsygankov "}, {"type": "b", "children": [{"type": "t", "text": "TULA-family proteins: Jacks of many trades and then some."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.26890"}], "href": "https://doi.org/10.1002/jcp.26890"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30076707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30076707"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yue Yin, David Frank, Weijie Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.013482"}], "href": "https://doi.org/10.1074/jbc.RA120.013482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32371395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32371395"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ksenia Krupina, Charlotte Kleiss, Thibaud Metzger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2015.12.017"}], "href": "https://doi.org/10.1016/j.devcel.2015.12.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26766443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26766443"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Elham Shahriyari, Mortaza Bonyadi, Mohammad Hossein Jabbarpoor Bonyadi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin Associated and SH3 Domain Containing B (UBASH3B) Gene Association with Behcet's Disease in Iranian Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Eye Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/02713683.2018.1524913"}], "href": "https://doi.org/10.1080/02713683.2018.1524913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30289285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30289285"}]}]}]}
Synonyms	STS-1, TULA-2, STS1, TULA2, P70
Proteins	UBS3B_HUMAN
NCBI Gene ID	84959
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UBASH3B has 7,715 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for UBASH3B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UBASH3B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBASH3B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBASH3B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UBASH3B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UBASH3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UBASH3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBASH3B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBASH3B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBASH3B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBASH3B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UBASH3B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UBASH3B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with UBASH3B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBASH3B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UBASH3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UBASH3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of UBASH3B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UBASH3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing UBASH3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing UBASH3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with UBASH3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UBASH3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBASH3B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UBASH3B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with UBASH3B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with UBASH3B gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with UBASH3B gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by UBASH3B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for UBASH3B protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with UBASH3B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UBASH3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UBASH3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UBASH3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UBASH3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UBASH3B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBASH3B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UBASH3B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing UBASH3B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with UBASH3B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with UBASH3B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing UBASH3B from the GeneSigDB Published Gene Signatures dataset.